AIP

 

Full name: aryl hydrocarbon receptor interacting protein Alias Symbol: XAP2|ARA9|FKBP16
Type: protein-coding gene Cytoband: 11q13.2
Entrez ID: 9049 HGNC ID: HGNC:358 Ensembl Gene: ENSG00000110711 OMIM ID: 605555
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of AIP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AIP 9049 201782_s_at 0.4648 0.2721
GSE20347 AIP 9049 201782_s_at 0.7123 0.0001
GSE23400 AIP 9049 201782_s_at 0.1842 0.0005
GSE26886 AIP 9049 201782_s_at 0.8426 0.0002
GSE29001 AIP 9049 201782_s_at 0.1397 0.3488
GSE38129 AIP 9049 201782_s_at 0.3101 0.0543
GSE45670 AIP 9049 201782_s_at 0.2417 0.1891
GSE53622 AIP 9049 85754 0.3234 0.0000
GSE53624 AIP 9049 85754 0.5546 0.0000
GSE63941 AIP 9049 201782_s_at 1.3006 0.0140
GSE77861 AIP 9049 201782_s_at 0.3888 0.0852
GSE97050 AIP 9049 A_23_P75380 0.1587 0.4634
SRP007169 AIP 9049 RNAseq 0.2011 0.6668
SRP008496 AIP 9049 RNAseq 0.2641 0.4211
SRP064894 AIP 9049 RNAseq 0.5447 0.1072
SRP133303 AIP 9049 RNAseq 0.2697 0.1330
SRP159526 AIP 9049 RNAseq 0.2454 0.2309
SRP193095 AIP 9049 RNAseq 0.5441 0.0000
SRP219564 AIP 9049 RNAseq 0.1902 0.6792
TCGA AIP 9049 RNAseq 0.0958 0.1415

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by AIP expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AIP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AIP 9049 10 3 17
GSE20123 AIP 9049 10 3 17
GSE43470 AIP 9049 5 2 36
GSE46452 AIP 9049 14 3 42
GSE47630 AIP 9049 8 5 27
GSE54993 AIP 9049 3 1 66
GSE54994 AIP 9049 13 4 36
GSE60625 AIP 9049 0 3 8
GSE74703 AIP 9049 4 1 31
GSE74704 AIP 9049 8 1 11
TCGA AIP 9049 30 8 58

Total number of gains: 105; Total number of losses: 34; Total Number of normals: 349.  

 

Somatic mutations of AIP:

 

Generating mutation plots.

 

Highly correlated genes for AIP:

 

Showing top 20/1295 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AIPRAB340.764975303
AIPZNF4960.745437404
AIPATXN1L0.736398303
AIPCYSTM10.734147404
AIPKRTCAP20.727757403
AIPR3HDM20.727648303
AIPELOF10.72626404
AIPLINC006670.7227303
AIPC17orf670.720321303
AIPZNF8370.715905303
AIPPMF10.714229303
AIPUSP140.708881303
AIPRPS140.707661303
AIPRFTN20.698799403
AIPXXYLT10.698572303
AIPCCDC1270.698559404
AIPRILPL10.696648303
AIPC7orf500.695515504
AIPPPP1R16A0.694636303
AIPDNAJC110.692738403

For details and further investigation, click here