| Full name: ubiquitin specific peptidase 14 | Alias Symbol: TGT | ||
| Type: protein-coding gene | Cytoband: 18p11.32 | ||
| Entrez ID: 9097 | HGNC ID: HGNC:12612 | Ensembl Gene: ENSG00000101557 | OMIM ID: 607274 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of USP14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP14 | 9097 | 201672_s_at | 0.5014 | 0.4418 | |
| GSE20347 | USP14 | 9097 | 201672_s_at | 0.7096 | 0.0001 | |
| GSE23400 | USP14 | 9097 | 201672_s_at | 0.8033 | 0.0000 | |
| GSE26886 | USP14 | 9097 | 201672_s_at | 0.3617 | 0.1474 | |
| GSE29001 | USP14 | 9097 | 201672_s_at | 0.8828 | 0.0002 | |
| GSE38129 | USP14 | 9097 | 201672_s_at | 0.6973 | 0.0000 | |
| GSE45670 | USP14 | 9097 | 201672_s_at | 0.5511 | 0.0006 | |
| GSE53622 | USP14 | 9097 | 118179 | -0.1255 | 0.1954 | |
| GSE53624 | USP14 | 9097 | 118179 | -0.0439 | 0.6374 | |
| GSE63941 | USP14 | 9097 | 201672_s_at | 0.1517 | 0.7784 | |
| GSE77861 | USP14 | 9097 | 201672_s_at | 0.9148 | 0.0017 | |
| GSE97050 | USP14 | 9097 | A_33_P3239954 | -0.3190 | 0.2858 | |
| SRP007169 | USP14 | 9097 | RNAseq | 1.2219 | 0.0023 | |
| SRP008496 | USP14 | 9097 | RNAseq | 1.4100 | 0.0000 | |
| SRP064894 | USP14 | 9097 | RNAseq | 0.4825 | 0.0647 | |
| SRP133303 | USP14 | 9097 | RNAseq | 0.8044 | 0.0001 | |
| SRP159526 | USP14 | 9097 | RNAseq | 0.4260 | 0.0341 | |
| SRP193095 | USP14 | 9097 | RNAseq | 0.3937 | 0.0006 | |
| SRP219564 | USP14 | 9097 | RNAseq | 0.0814 | 0.7437 | |
| TCGA | USP14 | 9097 | RNAseq | 0.1686 | 0.0007 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by USP14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP14 | 9097 | 6 | 4 | 20 | |
| GSE20123 | USP14 | 9097 | 6 | 4 | 20 | |
| GSE43470 | USP14 | 9097 | 1 | 5 | 37 | |
| GSE46452 | USP14 | 9097 | 4 | 20 | 35 | |
| GSE47630 | USP14 | 9097 | 7 | 18 | 15 | |
| GSE54993 | USP14 | 9097 | 6 | 3 | 61 | |
| GSE54994 | USP14 | 9097 | 11 | 8 | 34 | |
| GSE60625 | USP14 | 9097 | 0 | 4 | 7 | |
| GSE74703 | USP14 | 9097 | 1 | 2 | 33 | |
| GSE74704 | USP14 | 9097 | 4 | 2 | 14 | |
| TCGA | USP14 | 9097 | 34 | 19 | 43 |
Total number of gains: 80; Total number of losses: 89; Total Number of normals: 319.
Somatic mutations of USP14:
Generating mutation plots.
Highly correlated genes for USP14:
Showing top 20/1550 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP14 | SPOPL | 0.815455 | 3 | 0 | 3 |
| USP14 | PTGFRN | 0.79709 | 3 | 0 | 3 |
| USP14 | MRPS5 | 0.776439 | 3 | 0 | 3 |
| USP14 | MICALCL | 0.776134 | 3 | 0 | 3 |
| USP14 | NIPA1 | 0.763664 | 3 | 0 | 3 |
| USP14 | RFTN1 | 0.758159 | 3 | 0 | 3 |
| USP14 | ALKBH6 | 0.753461 | 4 | 0 | 4 |
| USP14 | IWS1 | 0.748038 | 4 | 0 | 3 |
| USP14 | NEDD1 | 0.747584 | 4 | 0 | 3 |
| USP14 | TRMT5 | 0.746035 | 3 | 0 | 3 |
| USP14 | SPRED1 | 0.738882 | 3 | 0 | 3 |
| USP14 | GMPS | 0.738419 | 8 | 0 | 8 |
| USP14 | BOLA1 | 0.737801 | 3 | 0 | 3 |
| USP14 | TIA1 | 0.737576 | 4 | 0 | 4 |
| USP14 | POU6F2-AS2 | 0.732181 | 3 | 0 | 3 |
| USP14 | NDUFV2 | 0.731432 | 3 | 0 | 3 |
| USP14 | SNRNP200 | 0.731021 | 3 | 0 | 3 |
| USP14 | TMEM185B | 0.72881 | 8 | 0 | 8 |
| USP14 | AGPAT4 | 0.728427 | 3 | 0 | 3 |
| USP14 | SLC37A3 | 0.725585 | 3 | 0 | 3 |
For details and further investigation, click here
