| Full name: angiopoietin 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 51378 | HGNC ID: HGNC:487 | Ensembl Gene: ENSG00000101280 | OMIM ID: 603705 |
| Drug and gene relationship at DGIdb | |||
ANGPT4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of ANGPT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANGPT4 | 51378 | 221134_at | -0.1523 | 0.5931 | |
| GSE20347 | ANGPT4 | 51378 | 221134_at | -0.0562 | 0.5633 | |
| GSE23400 | ANGPT4 | 51378 | 221134_at | -0.2159 | 0.0000 | |
| GSE26886 | ANGPT4 | 51378 | 221134_at | 0.1571 | 0.1705 | |
| GSE29001 | ANGPT4 | 51378 | 221134_at | -0.1776 | 0.1849 | |
| GSE38129 | ANGPT4 | 51378 | 221134_at | -0.1647 | 0.0474 | |
| GSE45670 | ANGPT4 | 51378 | 221134_at | 0.0758 | 0.4402 | |
| GSE53622 | ANGPT4 | 51378 | 129602 | 0.3437 | 0.0614 | |
| GSE53624 | ANGPT4 | 51378 | 129602 | 0.4763 | 0.0000 | |
| GSE63941 | ANGPT4 | 51378 | 221134_at | 0.2455 | 0.1560 | |
| GSE77861 | ANGPT4 | 51378 | 221134_at | -0.0877 | 0.5077 | |
| GSE97050 | ANGPT4 | 51378 | A_23_P68511 | -0.0018 | 0.9954 | |
| SRP133303 | ANGPT4 | 51378 | RNAseq | 0.0015 | 0.9945 | |
| SRP193095 | ANGPT4 | 51378 | RNAseq | 0.1623 | 0.3658 | |
| SRP219564 | ANGPT4 | 51378 | RNAseq | 0.5192 | 0.3657 | |
| TCGA | ANGPT4 | 51378 | RNAseq | -0.9690 | 0.2226 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ANGPT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANGPT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANGPT4 | 51378 | 12 | 4 | 14 | |
| GSE20123 | ANGPT4 | 51378 | 13 | 4 | 13 | |
| GSE43470 | ANGPT4 | 51378 | 12 | 1 | 30 | |
| GSE46452 | ANGPT4 | 51378 | 26 | 1 | 32 | |
| GSE47630 | ANGPT4 | 51378 | 19 | 4 | 17 | |
| GSE54993 | ANGPT4 | 51378 | 2 | 15 | 53 | |
| GSE54994 | ANGPT4 | 51378 | 24 | 2 | 27 | |
| GSE60625 | ANGPT4 | 51378 | 0 | 0 | 11 | |
| GSE74703 | ANGPT4 | 51378 | 11 | 1 | 24 | |
| GSE74704 | ANGPT4 | 51378 | 8 | 2 | 10 | |
| TCGA | ANGPT4 | 51378 | 41 | 11 | 44 |
Total number of gains: 168; Total number of losses: 45; Total Number of normals: 275.
Somatic mutations of ANGPT4:
Generating mutation plots.
Highly correlated genes for ANGPT4:
Showing top 20/1249 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANGPT4 | OR4A15 | 0.777066 | 3 | 0 | 3 |
| ANGPT4 | OR2A5 | 0.775127 | 3 | 0 | 3 |
| ANGPT4 | STRC | 0.771668 | 3 | 0 | 3 |
| ANGPT4 | PRAMEF5 | 0.769998 | 3 | 0 | 3 |
| ANGPT4 | HRC | 0.768977 | 4 | 0 | 4 |
| ANGPT4 | C7orf61 | 0.760128 | 3 | 0 | 3 |
| ANGPT4 | TMEM63A | 0.759158 | 3 | 0 | 3 |
| ANGPT4 | NT5C1A | 0.756535 | 4 | 0 | 4 |
| ANGPT4 | OR2T1 | 0.750897 | 3 | 0 | 3 |
| ANGPT4 | PLA2G2C | 0.739154 | 3 | 0 | 3 |
| ANGPT4 | KRTAP10-12 | 0.738424 | 3 | 0 | 3 |
| ANGPT4 | OR4D6 | 0.738226 | 3 | 0 | 3 |
| ANGPT4 | DEFB108B | 0.73587 | 4 | 0 | 4 |
| ANGPT4 | B3GNT8 | 0.731608 | 3 | 0 | 3 |
| ANGPT4 | MFSD6L | 0.731145 | 4 | 0 | 4 |
| ANGPT4 | C19orf71 | 0.730277 | 3 | 0 | 3 |
| ANGPT4 | DEFB128 | 0.72915 | 3 | 0 | 3 |
| ANGPT4 | KIF19 | 0.727453 | 4 | 0 | 4 |
| ANGPT4 | CRYGN | 0.727033 | 3 | 0 | 3 |
| ANGPT4 | OR2T27 | 0.725685 | 3 | 0 | 3 |
For details and further investigation, click here
