| Full name: apolipoprotein B mRNA editing enzyme catalytic subunit 2 | Alias Symbol: ARCD1|ARP1 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 10930 | HGNC ID: HGNC:605 | Ensembl Gene: ENSG00000124701 | OMIM ID: 604797 |
| Drug and gene relationship at DGIdb | |||
Expression of APOBEC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOBEC2 | 10930 | 206160_at | -0.1184 | 0.6678 | |
| GSE20347 | APOBEC2 | 10930 | 206160_at | 0.0714 | 0.5101 | |
| GSE23400 | APOBEC2 | 10930 | 206160_at | -0.2318 | 0.0000 | |
| GSE26886 | APOBEC2 | 10930 | 206160_at | -0.1196 | 0.3285 | |
| GSE29001 | APOBEC2 | 10930 | 206160_at | -0.1447 | 0.2547 | |
| GSE38129 | APOBEC2 | 10930 | 206160_at | -0.2891 | 0.0452 | |
| GSE45670 | APOBEC2 | 10930 | 206160_at | -0.1418 | 0.1339 | |
| GSE53622 | APOBEC2 | 10930 | 59277 | -0.0628 | 0.4412 | |
| GSE53624 | APOBEC2 | 10930 | 59277 | -0.0951 | 0.4193 | |
| GSE63941 | APOBEC2 | 10930 | 206160_at | 0.4473 | 0.0020 | |
| GSE77861 | APOBEC2 | 10930 | 206160_at | -0.1292 | 0.1500 | |
| GSE97050 | APOBEC2 | 10930 | A_23_P70387 | 0.0687 | 0.8072 | |
| SRP133303 | APOBEC2 | 10930 | RNAseq | -0.5225 | 0.0348 | |
| TCGA | APOBEC2 | 10930 | RNAseq | -2.5966 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by APOBEC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOBEC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOBEC2 | 10930 | 3 | 3 | 24 | |
| GSE20123 | APOBEC2 | 10930 | 3 | 3 | 24 | |
| GSE43470 | APOBEC2 | 10930 | 6 | 0 | 37 | |
| GSE46452 | APOBEC2 | 10930 | 2 | 9 | 48 | |
| GSE47630 | APOBEC2 | 10930 | 8 | 4 | 28 | |
| GSE54993 | APOBEC2 | 10930 | 3 | 2 | 65 | |
| GSE54994 | APOBEC2 | 10930 | 11 | 4 | 38 | |
| GSE60625 | APOBEC2 | 10930 | 0 | 1 | 10 | |
| GSE74703 | APOBEC2 | 10930 | 6 | 0 | 30 | |
| GSE74704 | APOBEC2 | 10930 | 1 | 3 | 16 | |
| TCGA | APOBEC2 | 10930 | 19 | 13 | 64 |
Total number of gains: 62; Total number of losses: 42; Total Number of normals: 384.
Somatic mutations of APOBEC2:
Generating mutation plots.
Highly correlated genes for APOBEC2:
Showing top 20/728 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOBEC2 | COPG2 | 0.770995 | 3 | 0 | 3 |
| APOBEC2 | CHCHD10 | 0.761943 | 3 | 0 | 3 |
| APOBEC2 | ZNF878 | 0.741907 | 3 | 0 | 3 |
| APOBEC2 | FAM47A | 0.738982 | 4 | 0 | 4 |
| APOBEC2 | TP53AIP1 | 0.734915 | 3 | 0 | 3 |
| APOBEC2 | WDR64 | 0.727494 | 3 | 0 | 3 |
| APOBEC2 | ZNF676 | 0.727144 | 3 | 0 | 3 |
| APOBEC2 | ZNF10 | 0.724966 | 3 | 0 | 3 |
| APOBEC2 | HMGCS1 | 0.724296 | 3 | 0 | 3 |
| APOBEC2 | GGN | 0.722515 | 3 | 0 | 3 |
| APOBEC2 | TSHR | 0.714007 | 4 | 0 | 4 |
| APOBEC2 | GALR1 | 0.709888 | 3 | 0 | 3 |
| APOBEC2 | SLC32A1 | 0.709004 | 3 | 0 | 3 |
| APOBEC2 | KRTAP19-2 | 0.705185 | 3 | 0 | 3 |
| APOBEC2 | ADAMTSL5 | 0.703947 | 3 | 0 | 3 |
| APOBEC2 | KRTAP21-2 | 0.698847 | 3 | 0 | 3 |
| APOBEC2 | ZNF263 | 0.692895 | 3 | 0 | 3 |
| APOBEC2 | TMEM132C | 0.689858 | 3 | 0 | 3 |
| APOBEC2 | GPR15 | 0.687736 | 3 | 0 | 3 |
| APOBEC2 | EGR1 | 0.68773 | 3 | 0 | 3 |
For details and further investigation, click here
