| Full name: thyroid stimulating hormone receptor | Alias Symbol: LGR3 | ||
| Type: protein-coding gene | Cytoband: 14q24-q31 | ||
| Entrez ID: 7253 | HGNC ID: HGNC:12373 | Ensembl Gene: ENSG00000165409 | OMIM ID: 603372 |
| Drug and gene relationship at DGIdb | |||
TSHR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04918 | Thyroid hormone synthesis | |
| hsa04923 | Regulation of lipolysis in adipocytes |
Expression of TSHR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSHR | 7253 | 215443_at | 0.2013 | 0.3133 | |
| GSE20347 | TSHR | 7253 | 215443_at | 0.0276 | 0.7149 | |
| GSE23400 | TSHR | 7253 | 210055_at | -0.0932 | 0.0000 | |
| GSE26886 | TSHR | 7253 | 215442_s_at | 0.0250 | 0.8291 | |
| GSE29001 | TSHR | 7253 | 210055_at | -0.0779 | 0.5333 | |
| GSE38129 | TSHR | 7253 | 215443_at | 0.0182 | 0.7575 | |
| GSE45670 | TSHR | 7253 | 215442_s_at | 0.0601 | 0.3897 | |
| GSE53622 | TSHR | 7253 | 50185 | 0.5134 | 0.0390 | |
| GSE53624 | TSHR | 7253 | 50185 | 0.3416 | 0.0485 | |
| GSE63941 | TSHR | 7253 | 215443_at | -0.0025 | 0.9859 | |
| GSE77861 | TSHR | 7253 | 215442_s_at | -0.0721 | 0.4720 | |
| GSE97050 | TSHR | 7253 | A_24_P42557 | 0.3749 | 0.1939 | |
| SRP133303 | TSHR | 7253 | RNAseq | 0.1809 | 0.6635 | |
| TCGA | TSHR | 7253 | RNAseq | -0.8210 | 0.0565 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TSHR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSHR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSHR | 7253 | 9 | 3 | 18 | |
| GSE20123 | TSHR | 7253 | 9 | 3 | 18 | |
| GSE43470 | TSHR | 7253 | 8 | 3 | 32 | |
| GSE46452 | TSHR | 7253 | 16 | 3 | 40 | |
| GSE47630 | TSHR | 7253 | 11 | 8 | 21 | |
| GSE54993 | TSHR | 7253 | 3 | 8 | 59 | |
| GSE54994 | TSHR | 7253 | 19 | 4 | 30 | |
| GSE60625 | TSHR | 7253 | 0 | 2 | 9 | |
| GSE74703 | TSHR | 7253 | 7 | 3 | 26 | |
| GSE74704 | TSHR | 7253 | 4 | 3 | 13 | |
| TCGA | TSHR | 7253 | 31 | 19 | 46 |
Total number of gains: 117; Total number of losses: 59; Total Number of normals: 312.
Somatic mutations of TSHR:
Generating mutation plots.
Highly correlated genes for TSHR:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSHR | TP53I11 | 0.839505 | 3 | 0 | 3 |
| TSHR | FOXP4 | 0.76126 | 3 | 0 | 3 |
| TSHR | ZNF324B | 0.752991 | 3 | 0 | 3 |
| TSHR | PVR | 0.751372 | 4 | 0 | 4 |
| TSHR | PELP1 | 0.748378 | 3 | 0 | 3 |
| TSHR | UBE2N | 0.740279 | 3 | 0 | 3 |
| TSHR | ZNF584 | 0.739185 | 3 | 0 | 3 |
| TSHR | TEAD2 | 0.738684 | 3 | 0 | 3 |
| TSHR | MED24 | 0.731776 | 5 | 0 | 5 |
| TSHR | HHLA1 | 0.723316 | 4 | 0 | 4 |
| TSHR | BTN1A1 | 0.722956 | 4 | 0 | 4 |
| TSHR | IFT122 | 0.716052 | 4 | 0 | 4 |
| TSHR | APOBEC2 | 0.714007 | 4 | 0 | 4 |
| TSHR | ESM1 | 0.713651 | 3 | 0 | 3 |
| TSHR | CD3EAP | 0.711991 | 3 | 0 | 3 |
| TSHR | ZNF408 | 0.711914 | 4 | 0 | 3 |
| TSHR | MYT1 | 0.709727 | 4 | 0 | 4 |
| TSHR | MTHFR | 0.708808 | 3 | 0 | 3 |
| TSHR | KIAA0513 | 0.708782 | 3 | 0 | 3 |
| TSHR | TG | 0.708066 | 4 | 0 | 4 |
For details and further investigation, click here
