| Full name: 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p12 | ||
| Entrez ID: 3157 | HGNC ID: HGNC:5007 | Ensembl Gene: ENSG00000112972 | OMIM ID: 142940 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HMGCS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGCS1 | 3157 | 221750_at | -0.7663 | 0.1934 | |
| GSE20347 | HMGCS1 | 3157 | 221750_at | -0.8463 | 0.0000 | |
| GSE23400 | HMGCS1 | 3157 | 205822_s_at | -0.4556 | 0.0055 | |
| GSE26886 | HMGCS1 | 3157 | 221750_at | -1.0340 | 0.0246 | |
| GSE29001 | HMGCS1 | 3157 | 221750_at | -0.9683 | 0.0427 | |
| GSE38129 | HMGCS1 | 3157 | 221750_at | -0.4411 | 0.1597 | |
| GSE45670 | HMGCS1 | 3157 | 221750_at | -0.3946 | 0.1508 | |
| GSE53622 | HMGCS1 | 3157 | 108927 | -0.8896 | 0.0000 | |
| GSE53624 | HMGCS1 | 3157 | 108927 | -0.9933 | 0.0000 | |
| GSE63941 | HMGCS1 | 3157 | 205822_s_at | 3.3839 | 0.0003 | |
| GSE77861 | HMGCS1 | 3157 | 221750_at | -1.0267 | 0.0284 | |
| GSE97050 | HMGCS1 | 3157 | A_24_P63522 | -0.3966 | 0.4110 | |
| SRP007169 | HMGCS1 | 3157 | RNAseq | 0.1991 | 0.7950 | |
| SRP008496 | HMGCS1 | 3157 | RNAseq | -1.4020 | 0.0000 | |
| SRP064894 | HMGCS1 | 3157 | RNAseq | -2.0165 | 0.0000 | |
| SRP133303 | HMGCS1 | 3157 | RNAseq | -0.7768 | 0.0393 | |
| SRP193095 | HMGCS1 | 3157 | RNAseq | -1.1953 | 0.0000 | |
| SRP219564 | HMGCS1 | 3157 | RNAseq | -1.1955 | 0.0539 | |
| TCGA | HMGCS1 | 3157 | RNAseq | 0.1097 | 0.1568 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by HMGCS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGCS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGCS1 | 3157 | 10 | 0 | 20 | |
| GSE20123 | HMGCS1 | 3157 | 10 | 0 | 20 | |
| GSE43470 | HMGCS1 | 3157 | 17 | 0 | 26 | |
| GSE46452 | HMGCS1 | 3157 | 5 | 22 | 32 | |
| GSE47630 | HMGCS1 | 3157 | 6 | 12 | 22 | |
| GSE54993 | HMGCS1 | 3157 | 6 | 3 | 61 | |
| GSE54994 | HMGCS1 | 3157 | 24 | 2 | 27 | |
| GSE60625 | HMGCS1 | 3157 | 0 | 0 | 11 | |
| GSE74703 | HMGCS1 | 3157 | 13 | 0 | 23 | |
| GSE74704 | HMGCS1 | 3157 | 9 | 0 | 11 | |
| TCGA | HMGCS1 | 3157 | 53 | 6 | 37 |
Total number of gains: 153; Total number of losses: 45; Total Number of normals: 290.
Somatic mutations of HMGCS1:
Generating mutation plots.
Highly correlated genes for HMGCS1:
Showing top 20/1140 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGCS1 | TYSND1 | 0.794424 | 3 | 0 | 3 |
| HMGCS1 | RNF144B | 0.771724 | 3 | 0 | 3 |
| HMGCS1 | MRRF | 0.757239 | 3 | 0 | 3 |
| HMGCS1 | SYNE2 | 0.749731 | 3 | 0 | 3 |
| HMGCS1 | EBPL | 0.744818 | 3 | 0 | 3 |
| HMGCS1 | ARF5 | 0.741043 | 3 | 0 | 3 |
| HMGCS1 | MOB3B | 0.74085 | 3 | 0 | 3 |
| HMGCS1 | CA13 | 0.732839 | 3 | 0 | 3 |
| HMGCS1 | APOBEC2 | 0.724296 | 3 | 0 | 3 |
| HMGCS1 | MSMO1 | 0.719543 | 11 | 0 | 10 |
| HMGCS1 | GNL3 | 0.718333 | 4 | 0 | 4 |
| HMGCS1 | NDUFA7 | 0.712468 | 3 | 0 | 3 |
| HMGCS1 | HUS1 | 0.708881 | 3 | 0 | 3 |
| HMGCS1 | ECH1 | 0.707453 | 3 | 0 | 3 |
| HMGCS1 | KIF21A | 0.705949 | 6 | 0 | 6 |
| HMGCS1 | FRMD4B | 0.702626 | 12 | 0 | 11 |
| HMGCS1 | MRPS25 | 0.699527 | 3 | 0 | 3 |
| HMGCS1 | NDUFAF2 | 0.69947 | 3 | 0 | 3 |
| HMGCS1 | ZNF101 | 0.693746 | 4 | 0 | 4 |
| HMGCS1 | ATP6V1G1 | 0.693742 | 4 | 0 | 3 |
For details and further investigation, click here
