| Full name: Rho guanine nucleotide exchange factor 7 | Alias Symbol: KIAA0142|PIXB|DKFZp761K1021|Nbla10314|DKFZp686C12170|BETA-PIX|COOL1|P85SPR|P85|P85COOL1|P50BP|PAK3|P50 | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 8874 | HGNC ID: HGNC:15607 | Ensembl Gene: ENSG00000102606 | OMIM ID: 605477 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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ARHGEF7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ARHGEF7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF7 | 8874 | 202548_s_at | -0.1518 | 0.6023 | |
| GSE20347 | ARHGEF7 | 8874 | 202548_s_at | 0.1704 | 0.6385 | |
| GSE23400 | ARHGEF7 | 8874 | 202548_s_at | -0.0592 | 0.4788 | |
| GSE26886 | ARHGEF7 | 8874 | 202548_s_at | -0.5674 | 0.0492 | |
| GSE29001 | ARHGEF7 | 8874 | 202548_s_at | 0.0261 | 0.9211 | |
| GSE38129 | ARHGEF7 | 8874 | 202548_s_at | 0.0162 | 0.9470 | |
| GSE45670 | ARHGEF7 | 8874 | 202548_s_at | -0.1864 | 0.1689 | |
| GSE53622 | ARHGEF7 | 8874 | 119673 | -0.1198 | 0.1583 | |
| GSE53624 | ARHGEF7 | 8874 | 88886 | -0.1690 | 0.0129 | |
| GSE63941 | ARHGEF7 | 8874 | 202548_s_at | 0.0862 | 0.8726 | |
| GSE77861 | ARHGEF7 | 8874 | 202548_s_at | -0.1692 | 0.5994 | |
| GSE97050 | ARHGEF7 | 8874 | A_33_P3288904 | -0.0091 | 0.9713 | |
| SRP007169 | ARHGEF7 | 8874 | RNAseq | 0.3793 | 0.3075 | |
| SRP008496 | ARHGEF7 | 8874 | RNAseq | 0.5020 | 0.0465 | |
| SRP064894 | ARHGEF7 | 8874 | RNAseq | 0.3290 | 0.0380 | |
| SRP133303 | ARHGEF7 | 8874 | RNAseq | -0.0266 | 0.8053 | |
| SRP159526 | ARHGEF7 | 8874 | RNAseq | -0.1632 | 0.4398 | |
| SRP193095 | ARHGEF7 | 8874 | RNAseq | 0.0059 | 0.9590 | |
| SRP219564 | ARHGEF7 | 8874 | RNAseq | 0.0525 | 0.8403 | |
| TCGA | ARHGEF7 | 8874 | RNAseq | -0.1367 | 0.0027 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGEF7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF7 | 8874 | 6 | 11 | 13 | |
| GSE20123 | ARHGEF7 | 8874 | 6 | 10 | 14 | |
| GSE43470 | ARHGEF7 | 8874 | 4 | 13 | 26 | |
| GSE46452 | ARHGEF7 | 8874 | 2 | 31 | 26 | |
| GSE47630 | ARHGEF7 | 8874 | 3 | 26 | 11 | |
| GSE54993 | ARHGEF7 | 8874 | 11 | 4 | 55 | |
| GSE54994 | ARHGEF7 | 8874 | 8 | 8 | 37 | |
| GSE60625 | ARHGEF7 | 8874 | 0 | 3 | 8 | |
| GSE74703 | ARHGEF7 | 8874 | 3 | 9 | 24 | |
| GSE74704 | ARHGEF7 | 8874 | 4 | 9 | 7 | |
| TCGA | ARHGEF7 | 8874 | 19 | 34 | 43 |
Total number of gains: 66; Total number of losses: 158; Total Number of normals: 264.
Somatic mutations of ARHGEF7:
Generating mutation plots.
Highly correlated genes for ARHGEF7:
Showing top 20/201 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF7 | COG6 | 0.816767 | 3 | 0 | 3 |
| ARHGEF7 | SMARCA2 | 0.797126 | 3 | 0 | 3 |
| ARHGEF7 | SVIP | 0.784111 | 3 | 0 | 3 |
| ARHGEF7 | ANKRD44 | 0.771384 | 3 | 0 | 3 |
| ARHGEF7 | MYO5C | 0.764368 | 3 | 0 | 3 |
| ARHGEF7 | ZNF441 | 0.752884 | 3 | 0 | 3 |
| ARHGEF7 | ANKFY1 | 0.751973 | 3 | 0 | 3 |
| ARHGEF7 | PPM1K | 0.744807 | 3 | 0 | 3 |
| ARHGEF7 | CKAP2 | 0.74013 | 3 | 0 | 3 |
| ARHGEF7 | CD99 | 0.738797 | 3 | 0 | 3 |
| ARHGEF7 | OS9 | 0.719282 | 3 | 0 | 3 |
| ARHGEF7 | PPM1D | 0.716944 | 3 | 0 | 3 |
| ARHGEF7 | ZNF490 | 0.708132 | 3 | 0 | 3 |
| ARHGEF7 | GNPDA2 | 0.707644 | 4 | 0 | 3 |
| ARHGEF7 | PARP4 | 0.700626 | 5 | 0 | 5 |
| ARHGEF7 | RNASEL | 0.699987 | 3 | 0 | 3 |
| ARHGEF7 | GLCCI1 | 0.698557 | 3 | 0 | 3 |
| ARHGEF7 | TMEM185A | 0.697666 | 3 | 0 | 3 |
| ARHGEF7 | APBB1IP | 0.696595 | 3 | 0 | 3 |
| ARHGEF7 | SYNRG | 0.695813 | 4 | 0 | 3 |
For details and further investigation, click here
