| Full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | Alias Symbol: BAF190|hSNF2a|hBRM|Sth1p|SNF2LA|BRM|SNF2|SWI2 | ||
| Type: protein-coding gene | Cytoband: 9p24.3 | ||
| Entrez ID: 6595 | HGNC ID: HGNC:11098 | Ensembl Gene: ENSG00000080503 | OMIM ID: 600014 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMARCA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMARCA2 | 6595 | 217707_x_at | -0.8091 | 0.1341 | |
| GSE20347 | SMARCA2 | 6595 | 217707_x_at | -0.6804 | 0.0003 | |
| GSE23400 | SMARCA2 | 6595 | 217707_x_at | -0.4422 | 0.0004 | |
| GSE26886 | SMARCA2 | 6595 | 217707_x_at | -0.3896 | 0.1630 | |
| GSE29001 | SMARCA2 | 6595 | 217707_x_at | -0.2207 | 0.4749 | |
| GSE38129 | SMARCA2 | 6595 | 217707_x_at | -0.7372 | 0.0000 | |
| GSE45670 | SMARCA2 | 6595 | 217707_x_at | -0.9861 | 0.0000 | |
| GSE53622 | SMARCA2 | 6595 | 119417 | -0.6352 | 0.0000 | |
| GSE53624 | SMARCA2 | 6595 | 99448 | -0.3525 | 0.0000 | |
| GSE63941 | SMARCA2 | 6595 | 217707_x_at | -2.3596 | 0.1198 | |
| GSE77861 | SMARCA2 | 6595 | 217707_x_at | -1.1671 | 0.0325 | |
| GSE97050 | SMARCA2 | 6595 | A_23_P252764 | -0.5666 | 0.1009 | |
| SRP007169 | SMARCA2 | 6595 | RNAseq | 0.8746 | 0.0992 | |
| SRP008496 | SMARCA2 | 6595 | RNAseq | 0.3857 | 0.2255 | |
| SRP064894 | SMARCA2 | 6595 | RNAseq | -0.2385 | 0.1947 | |
| SRP133303 | SMARCA2 | 6595 | RNAseq | -0.8705 | 0.0000 | |
| SRP159526 | SMARCA2 | 6595 | RNAseq | -0.5272 | 0.0460 | |
| SRP193095 | SMARCA2 | 6595 | RNAseq | -0.6804 | 0.0000 | |
| SRP219564 | SMARCA2 | 6595 | RNAseq | -0.4307 | 0.3598 | |
| TCGA | SMARCA2 | 6595 | RNAseq | -0.1703 | 0.0113 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SMARCA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMARCA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMARCA2 | 6595 | 1 | 15 | 14 | |
| GSE20123 | SMARCA2 | 6595 | 1 | 15 | 14 | |
| GSE43470 | SMARCA2 | 6595 | 3 | 14 | 26 | |
| GSE46452 | SMARCA2 | 6595 | 2 | 23 | 34 | |
| GSE47630 | SMARCA2 | 6595 | 4 | 27 | 9 | |
| GSE54993 | SMARCA2 | 6595 | 6 | 3 | 61 | |
| GSE54994 | SMARCA2 | 6595 | 11 | 17 | 25 | |
| GSE60625 | SMARCA2 | 6595 | 0 | 2 | 9 | |
| GSE74703 | SMARCA2 | 6595 | 3 | 11 | 22 | |
| GSE74704 | SMARCA2 | 6595 | 0 | 12 | 8 | |
| TCGA | SMARCA2 | 6595 | 13 | 52 | 31 |
Total number of gains: 44; Total number of losses: 191; Total Number of normals: 253.
Somatic mutations of SMARCA2:
Generating mutation plots.
Highly correlated genes for SMARCA2:
Showing top 20/1130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMARCA2 | ARHGEF7 | 0.797126 | 3 | 0 | 3 |
| SMARCA2 | FBXL3 | 0.780641 | 5 | 0 | 5 |
| SMARCA2 | CEP44 | 0.772071 | 3 | 0 | 3 |
| SMARCA2 | TMEM218 | 0.768254 | 3 | 0 | 3 |
| SMARCA2 | PREX2 | 0.762861 | 3 | 0 | 3 |
| SMARCA2 | ATF6 | 0.735884 | 3 | 0 | 3 |
| SMARCA2 | RHOJ | 0.733016 | 3 | 0 | 3 |
| SMARCA2 | C1GALT1C1 | 0.732805 | 3 | 0 | 3 |
| SMARCA2 | CETN2 | 0.731939 | 3 | 0 | 3 |
| SMARCA2 | GBP6 | 0.727822 | 3 | 0 | 3 |
| SMARCA2 | OLFML3 | 0.722174 | 3 | 0 | 3 |
| SMARCA2 | ZCCHC9 | 0.717844 | 3 | 0 | 3 |
| SMARCA2 | ZNF514 | 0.716101 | 3 | 0 | 3 |
| SMARCA2 | TMEM50B | 0.709743 | 4 | 0 | 4 |
| SMARCA2 | RNF38 | 0.705844 | 11 | 0 | 10 |
| SMARCA2 | ACVR2A | 0.702729 | 3 | 0 | 3 |
| SMARCA2 | PROSER1 | 0.698382 | 3 | 0 | 3 |
| SMARCA2 | AMOTL1 | 0.696689 | 4 | 0 | 3 |
| SMARCA2 | MSRB3 | 0.696237 | 4 | 0 | 3 |
| SMARCA2 | RERG | 0.69406 | 4 | 0 | 4 |
For details and further investigation, click here
