| Full name: ankyrin repeat and FYVE domain containing 1 | Alias Symbol: ANKHZN|KIAA1255|ZFYVE14|BTBD23|RANK-5 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 51479 | HGNC ID: HGNC:20763 | Ensembl Gene: ENSG00000185722 | OMIM ID: 607927 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ANKFY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANKFY1 | 51479 | 224900_at | 0.0167 | 0.9674 | |
| GSE20347 | ANKFY1 | 51479 | 219868_s_at | 0.0696 | 0.4195 | |
| GSE23400 | ANKFY1 | 51479 | 219868_s_at | 0.1282 | 0.0021 | |
| GSE26886 | ANKFY1 | 51479 | 224900_at | -0.1677 | 0.4416 | |
| GSE29001 | ANKFY1 | 51479 | 219868_s_at | 0.0371 | 0.8387 | |
| GSE38129 | ANKFY1 | 51479 | 219868_s_at | 0.0737 | 0.4813 | |
| GSE45670 | ANKFY1 | 51479 | 224900_at | 0.3071 | 0.0244 | |
| GSE63941 | ANKFY1 | 51479 | 224900_at | -0.8070 | 0.0378 | |
| GSE77861 | ANKFY1 | 51479 | 224900_at | 0.2559 | 0.4343 | |
| GSE97050 | ANKFY1 | 51479 | A_24_P151834 | 0.4579 | 0.2063 | |
| SRP007169 | ANKFY1 | 51479 | RNAseq | 1.1275 | 0.0070 | |
| SRP008496 | ANKFY1 | 51479 | RNAseq | 1.0211 | 0.0002 | |
| SRP064894 | ANKFY1 | 51479 | RNAseq | 0.2929 | 0.0554 | |
| SRP133303 | ANKFY1 | 51479 | RNAseq | 0.0162 | 0.9044 | |
| SRP159526 | ANKFY1 | 51479 | RNAseq | -0.0998 | 0.5609 | |
| SRP193095 | ANKFY1 | 51479 | RNAseq | 0.1887 | 0.0339 | |
| SRP219564 | ANKFY1 | 51479 | RNAseq | 0.2890 | 0.2054 | |
| TCGA | ANKFY1 | 51479 | RNAseq | -0.0630 | 0.1754 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ANKFY1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ANKFY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANKFY1 | 51479 | 5 | 2 | 23 | |
| GSE20123 | ANKFY1 | 51479 | 5 | 3 | 22 | |
| GSE43470 | ANKFY1 | 51479 | 1 | 6 | 36 | |
| GSE46452 | ANKFY1 | 51479 | 34 | 1 | 24 | |
| GSE47630 | ANKFY1 | 51479 | 7 | 1 | 32 | |
| GSE54993 | ANKFY1 | 51479 | 4 | 3 | 63 | |
| GSE54994 | ANKFY1 | 51479 | 5 | 9 | 39 | |
| GSE60625 | ANKFY1 | 51479 | 4 | 0 | 7 | |
| GSE74703 | ANKFY1 | 51479 | 1 | 3 | 32 | |
| GSE74704 | ANKFY1 | 51479 | 3 | 1 | 16 | |
| TCGA | ANKFY1 | 51479 | 18 | 22 | 56 |
Total number of gains: 87; Total number of losses: 51; Total Number of normals: 350.
Somatic mutations of ANKFY1:
Generating mutation plots.
Highly correlated genes for ANKFY1:
Showing top 20/241 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANKFY1 | AKAP5 | 0.796396 | 3 | 0 | 3 |
| ANKFY1 | ARHGEF7 | 0.751973 | 3 | 0 | 3 |
| ANKFY1 | RPAIN | 0.744907 | 3 | 0 | 3 |
| ANKFY1 | IFI16 | 0.743765 | 3 | 0 | 3 |
| ANKFY1 | ZNF292 | 0.741675 | 3 | 0 | 3 |
| ANKFY1 | SP110 | 0.729189 | 4 | 0 | 4 |
| ANKFY1 | ARV1 | 0.728373 | 3 | 0 | 3 |
| ANKFY1 | SUZ12 | 0.726863 | 3 | 0 | 3 |
| ANKFY1 | DSE | 0.720511 | 3 | 0 | 3 |
| ANKFY1 | NEK3 | 0.718439 | 4 | 0 | 3 |
| ANKFY1 | RSAD2 | 0.714741 | 3 | 0 | 3 |
| ANKFY1 | CMPK2 | 0.714709 | 3 | 0 | 3 |
| ANKFY1 | MED24 | 0.7072 | 4 | 0 | 4 |
| ANKFY1 | FBXL3 | 0.705653 | 3 | 0 | 3 |
| ANKFY1 | HEATR5B | 0.697481 | 3 | 0 | 3 |
| ANKFY1 | SEL1L3 | 0.687948 | 3 | 0 | 3 |
| ANKFY1 | SYNRG | 0.686655 | 3 | 0 | 3 |
| ANKFY1 | ATP9A | 0.685997 | 3 | 0 | 3 |
| ANKFY1 | DDX60 | 0.684273 | 4 | 0 | 4 |
| ANKFY1 | ITGB3 | 0.681168 | 3 | 0 | 3 |
For details and further investigation, click here
