| Full name: poly(ADP-ribose) polymerase family member 4 | Alias Symbol: VAULT3|p193|VPARP|VWA5C | ||
| Type: protein-coding gene | Cytoband: 13q12.12 | ||
| Entrez ID: 143 | HGNC ID: HGNC:271 | Ensembl Gene: ENSG00000102699 | OMIM ID: 607519 |
| Drug and gene relationship at DGIdb | |||
PARP4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of PARP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARP4 | 143 | 202239_at | -0.7049 | 0.0719 | |
| GSE20347 | PARP4 | 143 | 202239_at | -0.8326 | 0.0000 | |
| GSE23400 | PARP4 | 143 | 202239_at | -0.2571 | 0.0004 | |
| GSE26886 | PARP4 | 143 | 202239_at | -0.2887 | 0.3790 | |
| GSE29001 | PARP4 | 143 | 202239_at | -0.8045 | 0.0036 | |
| GSE38129 | PARP4 | 143 | 202239_at | -0.5060 | 0.0004 | |
| GSE45670 | PARP4 | 143 | 202239_at | -0.3247 | 0.1262 | |
| GSE53622 | PARP4 | 143 | 92125 | -0.8071 | 0.0000 | |
| GSE53624 | PARP4 | 143 | 92125 | -0.6021 | 0.0035 | |
| GSE63941 | PARP4 | 143 | 202239_at | -0.6273 | 0.1777 | |
| GSE77861 | PARP4 | 143 | 202239_at | -0.7041 | 0.0596 | |
| GSE97050 | PARP4 | A_21_P0011118 | -0.1190 | 0.7369 | ||
| SRP007169 | PARP4 | 143 | RNAseq | -1.1197 | 0.0001 | |
| SRP008496 | PARP4 | 143 | RNAseq | -0.9978 | 0.0000 | |
| SRP064894 | PARP4 | 143 | RNAseq | -0.2832 | 0.0816 | |
| SRP133303 | PARP4 | 143 | RNAseq | -0.4100 | 0.0010 | |
| SRP159526 | PARP4 | 143 | RNAseq | -0.8721 | 0.0359 | |
| SRP193095 | PARP4 | 143 | RNAseq | -0.5949 | 0.0006 | |
| SRP219564 | PARP4 | 143 | RNAseq | -0.6107 | 0.0427 | |
| TCGA | PARP4 | 143 | RNAseq | -0.1551 | 0.0049 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PARP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARP4 | 143 | 1 | 13 | 16 | |
| GSE20123 | PARP4 | 143 | 1 | 12 | 17 | |
| GSE43470 | PARP4 | 143 | 2 | 13 | 28 | |
| GSE46452 | PARP4 | 143 | 0 | 33 | 26 | |
| GSE47630 | PARP4 | 143 | 3 | 26 | 11 | |
| GSE54993 | PARP4 | 143 | 11 | 2 | 57 | |
| GSE54994 | PARP4 | 143 | 1 | 13 | 39 | |
| GSE60625 | PARP4 | 143 | 0 | 3 | 8 | |
| GSE74703 | PARP4 | 143 | 2 | 10 | 24 | |
| GSE74704 | PARP4 | 143 | 0 | 10 | 10 | |
| TCGA | PARP4 | 143 | 7 | 44 | 45 |
Total number of gains: 28; Total number of losses: 179; Total Number of normals: 281.
Somatic mutations of PARP4:
Generating mutation plots.
Highly correlated genes for PARP4:
Showing top 20/929 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARP4 | GAPVD1 | 0.724227 | 6 | 0 | 5 |
| PARP4 | COG5 | 0.718238 | 3 | 0 | 3 |
| PARP4 | ELL3 | 0.712455 | 3 | 0 | 3 |
| PARP4 | LDHD | 0.703536 | 3 | 0 | 3 |
| PARP4 | C2orf49 | 0.702732 | 3 | 0 | 3 |
| PARP4 | ARHGEF7 | 0.700626 | 5 | 0 | 5 |
| PARP4 | CDC16 | 0.697804 | 4 | 0 | 3 |
| PARP4 | PRKAG1 | 0.696935 | 3 | 0 | 3 |
| PARP4 | C2orf16 | 0.696191 | 3 | 0 | 3 |
| PARP4 | LRRD1 | 0.691715 | 3 | 0 | 3 |
| PARP4 | NBPF1 | 0.691479 | 3 | 0 | 3 |
| PARP4 | CCDC3 | 0.691445 | 3 | 0 | 3 |
| PARP4 | PPIL3 | 0.691388 | 5 | 0 | 5 |
| PARP4 | COX4I1 | 0.689093 | 3 | 0 | 3 |
| PARP4 | MAN2B2 | 0.686637 | 4 | 0 | 3 |
| PARP4 | AGPAT3 | 0.684273 | 4 | 0 | 3 |
| PARP4 | ULK3 | 0.68096 | 4 | 0 | 3 |
| PARP4 | KDM3A | 0.679902 | 4 | 0 | 3 |
| PARP4 | ARFGEF2 | 0.675636 | 3 | 0 | 3 |
| PARP4 | PCSK7 | 0.674736 | 4 | 0 | 4 |
For details and further investigation, click here
