| Full name: ribonuclease L | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 6041 | HGNC ID: HGNC:10050 | Ensembl Gene: ENSG00000135828 | OMIM ID: 180435 |
| Drug and gene relationship at DGIdb | |||
RNASEL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of RNASEL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASEL | 6041 | 229285_at | 0.0478 | 0.9426 | |
| GSE20347 | RNASEL | 6041 | 221287_at | -0.0463 | 0.6645 | |
| GSE23400 | RNASEL | 6041 | 221287_at | -0.1127 | 0.0006 | |
| GSE26886 | RNASEL | 6041 | 229285_at | -0.8708 | 0.0461 | |
| GSE29001 | RNASEL | 6041 | 221287_at | -0.0532 | 0.7691 | |
| GSE38129 | RNASEL | 6041 | 221287_at | -0.1262 | 0.2551 | |
| GSE45670 | RNASEL | 6041 | 229285_at | 0.3725 | 0.1476 | |
| GSE53622 | RNASEL | 6041 | 151011 | -0.3458 | 0.0041 | |
| GSE53624 | RNASEL | 6041 | 151011 | -0.3621 | 0.0157 | |
| GSE63941 | RNASEL | 6041 | 229285_at | -0.8534 | 0.2708 | |
| GSE77861 | RNASEL | 6041 | 229285_at | -0.0705 | 0.9015 | |
| GSE97050 | RNASEL | 6041 | A_23_P390172 | -0.0252 | 0.9322 | |
| SRP007169 | RNASEL | 6041 | RNAseq | 0.4891 | 0.4323 | |
| SRP008496 | RNASEL | 6041 | RNAseq | 0.8097 | 0.0169 | |
| SRP064894 | RNASEL | 6041 | RNAseq | 0.0354 | 0.8328 | |
| SRP133303 | RNASEL | 6041 | RNAseq | 0.0894 | 0.5335 | |
| SRP159526 | RNASEL | 6041 | RNAseq | 0.0959 | 0.8478 | |
| SRP193095 | RNASEL | 6041 | RNAseq | -0.1727 | 0.1653 | |
| SRP219564 | RNASEL | 6041 | RNAseq | -0.0230 | 0.9452 | |
| TCGA | RNASEL | 6041 | RNAseq | -0.1601 | 0.0145 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNASEL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASEL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASEL | 6041 | 12 | 0 | 18 | |
| GSE20123 | RNASEL | 6041 | 12 | 0 | 18 | |
| GSE43470 | RNASEL | 6041 | 7 | 1 | 35 | |
| GSE46452 | RNASEL | 6041 | 3 | 1 | 55 | |
| GSE47630 | RNASEL | 6041 | 14 | 0 | 26 | |
| GSE54993 | RNASEL | 6041 | 0 | 6 | 64 | |
| GSE54994 | RNASEL | 6041 | 15 | 0 | 38 | |
| GSE60625 | RNASEL | 6041 | 0 | 0 | 11 | |
| GSE74703 | RNASEL | 6041 | 7 | 1 | 28 | |
| GSE74704 | RNASEL | 6041 | 5 | 0 | 15 | |
| TCGA | RNASEL | 6041 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of RNASEL:
Generating mutation plots.
Highly correlated genes for RNASEL:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASEL | VPS29 | 0.781006 | 3 | 0 | 3 |
| RNASEL | CCDC6 | 0.761829 | 3 | 0 | 3 |
| RNASEL | ZBTB34 | 0.756698 | 3 | 0 | 3 |
| RNASEL | VPS26B | 0.752709 | 3 | 0 | 3 |
| RNASEL | PCGF3 | 0.749335 | 3 | 0 | 3 |
| RNASEL | CNOT6L | 0.735943 | 3 | 0 | 3 |
| RNASEL | ZNF395 | 0.734243 | 3 | 0 | 3 |
| RNASEL | TNRC6A | 0.732904 | 3 | 0 | 3 |
| RNASEL | PRKCH | 0.727565 | 3 | 0 | 3 |
| RNASEL | FBXO28 | 0.725665 | 3 | 0 | 3 |
| RNASEL | VCPIP1 | 0.721779 | 4 | 0 | 3 |
| RNASEL | FBXW11 | 0.720873 | 3 | 0 | 3 |
| RNASEL | PPM1L | 0.719967 | 3 | 0 | 3 |
| RNASEL | GLCCI1 | 0.719178 | 4 | 0 | 3 |
| RNASEL | NBPF1 | 0.719075 | 3 | 0 | 3 |
| RNASEL | RBBP6 | 0.718454 | 3 | 0 | 3 |
| RNASEL | STXBP5 | 0.713087 | 3 | 0 | 3 |
| RNASEL | EPS15 | 0.712729 | 3 | 0 | 3 |
| RNASEL | ZNF564 | 0.711937 | 4 | 0 | 4 |
| RNASEL | PPP1R2 | 0.71021 | 4 | 0 | 4 |
For details and further investigation, click here
