| Full name: cytoskeleton associated protein 2 | Alias Symbol: LB1|FLJ10749|se20-10|TMAP | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 26586 | HGNC ID: HGNC:1990 | Ensembl Gene: ENSG00000136108 | OMIM ID: 611569 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CKAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CKAP2 | 26586 | 218252_at | 0.8594 | 0.1403 | |
| GSE20347 | CKAP2 | 26586 | 218252_at | 0.7579 | 0.0012 | |
| GSE23400 | CKAP2 | 26586 | 218252_at | 0.8215 | 0.0000 | |
| GSE26886 | CKAP2 | 26586 | 218252_at | -0.1292 | 0.7660 | |
| GSE29001 | CKAP2 | 26586 | 218252_at | 1.0642 | 0.0059 | |
| GSE38129 | CKAP2 | 26586 | 218252_at | 1.1656 | 0.0000 | |
| GSE45670 | CKAP2 | 26586 | 218252_at | 0.6587 | 0.0011 | |
| GSE53622 | CKAP2 | 26586 | 17716 | 1.2164 | 0.0000 | |
| GSE53624 | CKAP2 | 26586 | 17716 | 1.2430 | 0.0000 | |
| GSE63941 | CKAP2 | 26586 | 218252_at | 1.4213 | 0.0231 | |
| GSE77861 | CKAP2 | 26586 | 218252_at | 0.3219 | 0.4897 | |
| GSE97050 | CKAP2 | 26586 | A_24_P99090 | 1.1201 | 0.1057 | |
| SRP007169 | CKAP2 | 26586 | RNAseq | 0.8984 | 0.0511 | |
| SRP008496 | CKAP2 | 26586 | RNAseq | 0.8356 | 0.0074 | |
| SRP064894 | CKAP2 | 26586 | RNAseq | 0.9193 | 0.0014 | |
| SRP133303 | CKAP2 | 26586 | RNAseq | 0.7249 | 0.0046 | |
| SRP159526 | CKAP2 | 26586 | RNAseq | 0.3892 | 0.2314 | |
| SRP193095 | CKAP2 | 26586 | RNAseq | 0.4837 | 0.0050 | |
| SRP219564 | CKAP2 | 26586 | RNAseq | 0.2403 | 0.7166 | |
| TCGA | CKAP2 | 26586 | RNAseq | 0.7922 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CKAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CKAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CKAP2 | 26586 | 2 | 12 | 16 | |
| GSE20123 | CKAP2 | 26586 | 2 | 11 | 17 | |
| GSE43470 | CKAP2 | 26586 | 2 | 12 | 29 | |
| GSE46452 | CKAP2 | 26586 | 0 | 32 | 27 | |
| GSE47630 | CKAP2 | 26586 | 2 | 27 | 11 | |
| GSE54993 | CKAP2 | 26586 | 12 | 2 | 56 | |
| GSE54994 | CKAP2 | 26586 | 1 | 15 | 37 | |
| GSE60625 | CKAP2 | 26586 | 0 | 3 | 8 | |
| GSE74703 | CKAP2 | 26586 | 2 | 10 | 24 | |
| GSE74704 | CKAP2 | 26586 | 0 | 9 | 11 | |
| TCGA | CKAP2 | 26586 | 10 | 35 | 51 |
Total number of gains: 33; Total number of losses: 168; Total Number of normals: 287.
Somatic mutations of CKAP2:
Generating mutation plots.
Highly correlated genes for CKAP2:
Showing top 20/1607 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CKAP2 | ASPM | 0.779522 | 13 | 0 | 12 |
| CKAP2 | RNF149 | 0.770225 | 3 | 0 | 3 |
| CKAP2 | MTX3 | 0.766229 | 3 | 0 | 3 |
| CKAP2 | TOP2A | 0.762845 | 12 | 0 | 11 |
| CKAP2 | NUSAP1 | 0.762831 | 12 | 0 | 12 |
| CKAP2 | NUF2 | 0.760823 | 8 | 0 | 8 |
| CKAP2 | CENPF | 0.757812 | 12 | 0 | 11 |
| CKAP2 | PRKDC | 0.751715 | 9 | 0 | 9 |
| CKAP2 | ARHGEF7 | 0.74013 | 3 | 0 | 3 |
| CKAP2 | MKI67 | 0.736637 | 11 | 0 | 11 |
| CKAP2 | MMS22L | 0.73662 | 3 | 0 | 3 |
| CKAP2 | NEK2 | 0.735409 | 13 | 0 | 12 |
| CKAP2 | DTL | 0.734846 | 12 | 0 | 10 |
| CKAP2 | KIF20A | 0.733647 | 12 | 0 | 10 |
| CKAP2 | KIF11 | 0.733643 | 13 | 0 | 13 |
| CKAP2 | HMMR | 0.731559 | 12 | 0 | 12 |
| CKAP2 | CBX3 | 0.731162 | 9 | 0 | 9 |
| CKAP2 | GMNN | 0.730997 | 12 | 0 | 11 |
| CKAP2 | NDC80 | 0.729248 | 12 | 0 | 11 |
| CKAP2 | BUB1B | 0.728795 | 8 | 0 | 8 |
For details and further investigation, click here
