| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1K | Alias Symbol: DKFZp761G058|PP2Ckappa|hPTMP|PP2Cm|BDP | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 152926 | HGNC ID: HGNC:25415 | Ensembl Gene: ENSG00000163644 | OMIM ID: 611065 |
| Drug and gene relationship at DGIdb | |||
Expression of PPM1K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1K | 152926 | 226773_at | -1.0311 | 0.1590 | |
| GSE26886 | PPM1K | 152926 | 226773_at | -2.3902 | 0.0000 | |
| GSE45670 | PPM1K | 152926 | 235061_at | -1.1489 | 0.0013 | |
| GSE53622 | PPM1K | 152926 | 20188 | -1.1186 | 0.0000 | |
| GSE53624 | PPM1K | 152926 | 20188 | -1.1863 | 0.0000 | |
| GSE63941 | PPM1K | 152926 | 226773_at | -1.6827 | 0.0295 | |
| GSE77861 | PPM1K | 152926 | 226773_at | -1.3871 | 0.0081 | |
| GSE97050 | PPM1K | 152926 | A_24_P214598 | -0.3997 | 0.1782 | |
| SRP007169 | PPM1K | 152926 | RNAseq | -2.1456 | 0.0000 | |
| SRP008496 | PPM1K | 152926 | RNAseq | -2.0061 | 0.0000 | |
| SRP064894 | PPM1K | 152926 | RNAseq | -0.9145 | 0.0000 | |
| SRP133303 | PPM1K | 152926 | RNAseq | -1.1286 | 0.0000 | |
| SRP159526 | PPM1K | 152926 | RNAseq | -1.2516 | 0.0003 | |
| SRP193095 | PPM1K | 152926 | RNAseq | -1.1239 | 0.0000 | |
| SRP219564 | PPM1K | 152926 | RNAseq | -0.9509 | 0.0012 | |
| TCGA | PPM1K | 152926 | RNAseq | -0.5366 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by PPM1K expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1K | 152926 | 3 | 12 | 15 | |
| GSE20123 | PPM1K | 152926 | 3 | 12 | 15 | |
| GSE43470 | PPM1K | 152926 | 0 | 13 | 30 | |
| GSE46452 | PPM1K | 152926 | 1 | 36 | 22 | |
| GSE47630 | PPM1K | 152926 | 0 | 20 | 20 | |
| GSE54993 | PPM1K | 152926 | 8 | 0 | 62 | |
| GSE54994 | PPM1K | 152926 | 1 | 10 | 42 | |
| GSE60625 | PPM1K | 152926 | 0 | 0 | 11 | |
| GSE74703 | PPM1K | 152926 | 0 | 11 | 25 | |
| GSE74704 | PPM1K | 152926 | 2 | 7 | 11 | |
| TCGA | PPM1K | 152926 | 12 | 37 | 47 |
Total number of gains: 30; Total number of losses: 158; Total Number of normals: 300.
Somatic mutations of PPM1K:
Generating mutation plots.
Highly correlated genes for PPM1K:
Showing top 20/1199 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1K | CGNL1 | 0.810219 | 7 | 0 | 7 |
| PPM1K | JAK2 | 0.808153 | 6 | 0 | 6 |
| PPM1K | HDHD2 | 0.797722 | 5 | 0 | 5 |
| PPM1K | FPGT | 0.781887 | 3 | 0 | 3 |
| PPM1K | GPD1L | 0.781634 | 7 | 0 | 7 |
| PPM1K | USP9Y | 0.777722 | 3 | 0 | 3 |
| PPM1K | APPL1 | 0.776187 | 6 | 0 | 6 |
| PPM1K | RBM20 | 0.774881 | 5 | 0 | 5 |
| PPM1K | TPCN1 | 0.772391 | 7 | 0 | 7 |
| PPM1K | GGA3 | 0.771349 | 4 | 0 | 4 |
| PPM1K | ZNF223 | 0.770383 | 3 | 0 | 3 |
| PPM1K | ELMO2 | 0.768882 | 5 | 0 | 5 |
| PPM1K | CAB39L | 0.768014 | 7 | 0 | 7 |
| PPM1K | CYB561 | 0.761242 | 3 | 0 | 3 |
| PPM1K | GALNT11 | 0.760278 | 4 | 0 | 4 |
| PPM1K | ECHDC2 | 0.751022 | 7 | 0 | 7 |
| PPM1K | TMEM218 | 0.750863 | 3 | 0 | 3 |
| PPM1K | CLEC3B | 0.747348 | 3 | 0 | 3 |
| PPM1K | PRR15L | 0.747039 | 4 | 0 | 4 |
| PPM1K | ARHGEF7 | 0.744807 | 3 | 0 | 3 |
For details and further investigation, click here
