PPM1D

 

Full name: protein phosphatase, Mg2+/Mn2+ dependent 1D Alias Symbol: Wip1|PP2C-DELTA
Type: protein-coding gene Cytoband: 17q23.3
Entrez ID: 8493 HGNC ID: HGNC:9277 Ensembl Gene: ENSG00000170836 OMIM ID: 605100
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 24/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PPM1D involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway

 

Expression of PPM1D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPM1D 8493 204566_at -0.4772 0.3287
GSE20347 PPM1D 8493 204566_at -0.5091 0.0233
GSE23400 PPM1D 8493 204566_at -0.1884 0.0003
GSE26886 PPM1D 8493 204566_at -1.1841 0.0004
GSE29001 PPM1D 8493 204566_at -0.5061 0.1037
GSE38129 PPM1D 8493 204566_at -0.3736 0.0363
GSE45670 PPM1D 8493 204566_at -0.3055 0.0605
GSE53622 PPM1D 8493 5988 -0.2274 0.0000
GSE53624 PPM1D 8493 5988 -0.2853 0.0000
GSE63941 PPM1D 8493 204566_at -0.8341 0.0555
GSE77861 PPM1D 8493 230330_at 0.1523 0.2780
GSE97050 PPM1D 8493 A_33_P3302696 -0.0335 0.8881
SRP007169 PPM1D 8493 RNAseq -1.0460 0.0042
SRP008496 PPM1D 8493 RNAseq -0.8745 0.0000
SRP064894 PPM1D 8493 RNAseq -0.5369 0.0023
SRP133303 PPM1D 8493 RNAseq 0.0603 0.6030
SRP159526 PPM1D 8493 RNAseq 0.0855 0.6375
SRP193095 PPM1D 8493 RNAseq -0.3746 0.0000
SRP219564 PPM1D 8493 RNAseq -0.5076 0.0472
TCGA PPM1D 8493 RNAseq -0.0866 0.1451

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by PPM1D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPM1D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPM1D 8493 5 1 24
GSE20123 PPM1D 8493 5 1 24
GSE43470 PPM1D 8493 5 0 38
GSE46452 PPM1D 8493 32 0 27
GSE47630 PPM1D 8493 7 1 32
GSE54993 PPM1D 8493 2 5 63
GSE54994 PPM1D 8493 9 5 39
GSE60625 PPM1D 8493 4 0 7
GSE74703 PPM1D 8493 5 0 31
GSE74704 PPM1D 8493 4 1 15
TCGA PPM1D 8493 29 7 60

Total number of gains: 107; Total number of losses: 21; Total Number of normals: 360.  

 

Somatic mutations of PPM1D:

 

Generating mutation plots.

 

Highly correlated genes for PPM1D:

 

Showing top 20/420 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPM1DSS180.792622303
PPM1DCASP30.790585303
PPM1DUBQLN10.768619303
PPM1DENDOD10.76772303
PPM1DUSP320.762232303
PPM1DCCNDBP10.757204404
PPM1DCHM0.749947404
PPM1DSPTLC20.747205303
PPM1DZNF5140.744378303
PPM1DFNIP20.74262303
PPM1DHSPA40.735389303
PPM1DDOK60.730868403
PPM1DARHGEF70.716944303
PPM1DCUL10.710964303
PPM1DEIF2S20.708402303
PPM1DC16orf720.708049403
PPM1DADAMTS90.70619303
PPM1DTUBB4B0.705745303
PPM1DPKNOX20.694745303
PPM1DPTGR10.690409403

For details and further investigation, click here