ASXL3

 

Full name: ASXL transcriptional regulator 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 18q12.1
Entrez ID: 80816 HGNC ID: HGNC:29357 Ensembl Gene: ENSG00000141431 OMIM ID: 615115
Drug and gene relationship at DGIdb

 

Expression of ASXL3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASXL3 80816 233686_at 0.0886 0.8090
GSE26886 ASXL3 80816 233686_at -0.1656 0.2688
GSE45670 ASXL3 80816 233686_at 0.0762 0.5582
GSE53622 ASXL3 80816 17318 0.1582 0.1472
GSE53624 ASXL3 80816 41867 -0.1170 0.3597
GSE63941 ASXL3 80816 233686_at 0.1511 0.3218
GSE77861 ASXL3 80816 233686_at -0.0367 0.7824
SRP133303 ASXL3 80816 RNAseq -0.1718 0.6167
TCGA ASXL3 80816 RNAseq -2.4635 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ASXL3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ASXL3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASXL3 80816 2 5 23
GSE20123 ASXL3 80816 2 6 22
GSE43470 ASXL3 80816 0 3 40
GSE46452 ASXL3 80816 1 25 33
GSE47630 ASXL3 80816 5 20 15
GSE54993 ASXL3 80816 7 1 62
GSE54994 ASXL3 80816 1 16 36
GSE60625 ASXL3 80816 0 4 7
GSE74703 ASXL3 80816 0 3 33
GSE74704 ASXL3 80816 1 5 14
TCGA ASXL3 80816 15 35 46

Total number of gains: 34; Total number of losses: 123; Total Number of normals: 331.  

 

Somatic mutations of ASXL3:

 

Generating mutation plots.

 

Highly correlated genes for ASXL3:

 

Showing all 14 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASXL3TLR100.663313303
ASXL3MORF4L2-AS10.648583404
ASXL3TRAF10.629323303
ASXL3NXPE40.612367303
ASXL3UNC5C0.601795303
ASXL3OR10A30.601379303
ASXL3PPP3R20.599127403
ASXL3TAGAP0.582725403
ASXL3TAT0.571008403
ASXL3HGF0.566866403
ASXL3SDCBP2-AS10.557443303
ASXL3PBOV10.547964403
ASXL3SUN50.543376503
ASXL3KCNIP20.532728403

For details and further investigation, click here