| Full name: TNF receptor associated factor 1 | Alias Symbol: EBI6 | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 7185 | HGNC ID: HGNC:12031 | Ensembl Gene: ENSG00000056558 | OMIM ID: 601711 |
| Drug and gene relationship at DGIdb | |||
TRAF1 involved pathways:
Expression of TRAF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRAF1 | 7185 | 205599_at | 0.0174 | 0.9797 | |
| GSE20347 | TRAF1 | 7185 | 205599_at | 0.0432 | 0.8051 | |
| GSE23400 | TRAF1 | 7185 | 205599_at | 0.0226 | 0.7811 | |
| GSE26886 | TRAF1 | 7185 | 205599_at | -0.0645 | 0.7068 | |
| GSE29001 | TRAF1 | 7185 | 205599_at | 0.0328 | 0.8775 | |
| GSE38129 | TRAF1 | 7185 | 205599_at | 0.0017 | 0.9906 | |
| GSE45670 | TRAF1 | 7185 | 205599_at | 0.0759 | 0.6196 | |
| GSE53622 | TRAF1 | 7185 | 9750 | -0.0874 | 0.6169 | |
| GSE53624 | TRAF1 | 7185 | 9750 | 0.2510 | 0.0416 | |
| GSE63941 | TRAF1 | 7185 | 205599_at | -0.4070 | 0.1872 | |
| GSE77861 | TRAF1 | 7185 | 205599_at | -0.0515 | 0.8375 | |
| GSE97050 | TRAF1 | 7185 | A_24_P89891 | 0.1487 | 0.5550 | |
| SRP007169 | TRAF1 | 7185 | RNAseq | 0.8740 | 0.2289 | |
| SRP064894 | TRAF1 | 7185 | RNAseq | 0.2008 | 0.4125 | |
| SRP133303 | TRAF1 | 7185 | RNAseq | 0.0842 | 0.6926 | |
| SRP193095 | TRAF1 | 7185 | RNAseq | 0.9406 | 0.0000 | |
| SRP219564 | TRAF1 | 7185 | RNAseq | -0.1244 | 0.6615 | |
| TCGA | TRAF1 | 7185 | RNAseq | -0.0456 | 0.6950 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRAF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRAF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRAF1 | 7185 | 3 | 7 | 20 | |
| GSE20123 | TRAF1 | 7185 | 3 | 7 | 20 | |
| GSE43470 | TRAF1 | 7185 | 5 | 4 | 34 | |
| GSE46452 | TRAF1 | 7185 | 6 | 13 | 40 | |
| GSE47630 | TRAF1 | 7185 | 3 | 16 | 21 | |
| GSE54993 | TRAF1 | 7185 | 3 | 3 | 64 | |
| GSE54994 | TRAF1 | 7185 | 9 | 10 | 34 | |
| GSE60625 | TRAF1 | 7185 | 0 | 0 | 11 | |
| GSE74703 | TRAF1 | 7185 | 5 | 3 | 28 | |
| GSE74704 | TRAF1 | 7185 | 2 | 5 | 13 | |
| TCGA | TRAF1 | 7185 | 27 | 26 | 43 |
Total number of gains: 66; Total number of losses: 94; Total Number of normals: 328.
Somatic mutations of TRAF1:
Generating mutation plots.
Highly correlated genes for TRAF1:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRAF1 | GRAMD1A | 0.720852 | 3 | 0 | 3 |
| TRAF1 | DHRSX | 0.705798 | 3 | 0 | 3 |
| TRAF1 | GGT5 | 0.689865 | 3 | 0 | 3 |
| TRAF1 | CD33 | 0.6855 | 4 | 0 | 3 |
| TRAF1 | KCTD18 | 0.681132 | 3 | 0 | 3 |
| TRAF1 | IFITM3 | 0.675109 | 3 | 0 | 3 |
| TRAF1 | TAGAP | 0.673169 | 5 | 0 | 4 |
| TRAF1 | C20orf96 | 0.668499 | 3 | 0 | 3 |
| TRAF1 | IL12RB1 | 0.657715 | 3 | 0 | 3 |
| TRAF1 | RNF166 | 0.6484 | 3 | 0 | 3 |
| TRAF1 | SPI1 | 0.644485 | 6 | 0 | 4 |
| TRAF1 | TNFSF13 | 0.64371 | 4 | 0 | 3 |
| TRAF1 | CD74 | 0.642221 | 8 | 0 | 7 |
| TRAF1 | ARHGAP9 | 0.636622 | 6 | 0 | 5 |
| TRAF1 | IFNAR1 | 0.636542 | 3 | 0 | 3 |
| TRAF1 | GAB3 | 0.635569 | 5 | 0 | 4 |
| TRAF1 | HMGN2 | 0.634817 | 3 | 0 | 3 |
| TRAF1 | KLRB1 | 0.63163 | 3 | 0 | 3 |
| TRAF1 | ASXL3 | 0.629323 | 3 | 0 | 3 |
| TRAF1 | KCNAB2 | 0.628201 | 6 | 0 | 4 |
For details and further investigation, click here
