| Full name: unc-5 netrin receptor C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q22.3 | ||
| Entrez ID: 8633 | HGNC ID: HGNC:12569 | Ensembl Gene: ENSG00000182168 | OMIM ID: 603610 |
| Drug and gene relationship at DGIdb | |||
UNC5C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of UNC5C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC5C | 8633 | 227838_at | -0.1169 | 0.7866 | |
| GSE20347 | UNC5C | 8633 | 206189_at | 0.0644 | 0.2991 | |
| GSE23400 | UNC5C | 8633 | 206189_at | -0.0171 | 0.4801 | |
| GSE26886 | UNC5C | 8633 | 227838_at | -0.1588 | 0.1755 | |
| GSE29001 | UNC5C | 8633 | 206189_at | 0.0764 | 0.6622 | |
| GSE38129 | UNC5C | 8633 | 206189_at | -0.0650 | 0.2234 | |
| GSE45670 | UNC5C | 8633 | 227838_at | -0.5686 | 0.0003 | |
| GSE53622 | UNC5C | 8633 | 136500 | -0.2374 | 0.1058 | |
| GSE53624 | UNC5C | 8633 | 136500 | 0.0665 | 0.6123 | |
| GSE63941 | UNC5C | 8633 | 227838_at | -3.4027 | 0.0000 | |
| GSE77861 | UNC5C | 8633 | 227838_at | -0.1561 | 0.0859 | |
| GSE97050 | UNC5C | 8633 | A_24_P42624 | -0.2813 | 0.4964 | |
| SRP007169 | UNC5C | 8633 | RNAseq | 3.3894 | 0.0011 | |
| SRP008496 | UNC5C | 8633 | RNAseq | 3.7190 | 0.0000 | |
| SRP064894 | UNC5C | 8633 | RNAseq | -0.0200 | 0.9474 | |
| SRP133303 | UNC5C | 8633 | RNAseq | -0.0172 | 0.9580 | |
| SRP219564 | UNC5C | 8633 | RNAseq | 0.4192 | 0.5496 | |
| TCGA | UNC5C | 8633 | RNAseq | -1.0307 | 0.0182 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by UNC5C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC5C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC5C | 8633 | 0 | 12 | 18 | |
| GSE20123 | UNC5C | 8633 | 0 | 12 | 18 | |
| GSE43470 | UNC5C | 8633 | 0 | 15 | 28 | |
| GSE46452 | UNC5C | 8633 | 1 | 36 | 22 | |
| GSE47630 | UNC5C | 8633 | 0 | 20 | 20 | |
| GSE54993 | UNC5C | 8633 | 8 | 0 | 62 | |
| GSE54994 | UNC5C | 8633 | 1 | 11 | 41 | |
| GSE60625 | UNC5C | 8633 | 0 | 3 | 8 | |
| GSE74703 | UNC5C | 8633 | 0 | 13 | 23 | |
| GSE74704 | UNC5C | 8633 | 0 | 6 | 14 | |
| TCGA | UNC5C | 8633 | 8 | 40 | 48 |
Total number of gains: 18; Total number of losses: 168; Total Number of normals: 302.
Somatic mutations of UNC5C:
Generating mutation plots.
Highly correlated genes for UNC5C:
Showing top 20/598 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC5C | ZNF521 | 0.747836 | 5 | 0 | 5 |
| UNC5C | DERL3 | 0.746781 | 3 | 0 | 3 |
| UNC5C | CNRIP1 | 0.742949 | 6 | 0 | 6 |
| UNC5C | ANO10 | 0.742417 | 3 | 0 | 3 |
| UNC5C | OLFML3 | 0.741076 | 6 | 0 | 6 |
| UNC5C | SPON1 | 0.725058 | 6 | 0 | 6 |
| UNC5C | TMEM176A | 0.72184 | 5 | 0 | 5 |
| UNC5C | FRZB | 0.718554 | 3 | 0 | 3 |
| UNC5C | FIBIN | 0.718317 | 5 | 0 | 4 |
| UNC5C | LINC01279 | 0.718298 | 3 | 0 | 3 |
| UNC5C | SNX25 | 0.718279 | 3 | 0 | 3 |
| UNC5C | RHBDF1 | 0.715683 | 3 | 0 | 3 |
| UNC5C | KCNJ2 | 0.71551 | 3 | 0 | 3 |
| UNC5C | STXBP4 | 0.714135 | 3 | 0 | 3 |
| UNC5C | RERE | 0.713344 | 3 | 0 | 3 |
| UNC5C | ZNF608 | 0.70659 | 3 | 0 | 3 |
| UNC5C | LYRM7 | 0.704525 | 3 | 0 | 3 |
| UNC5C | PTGER2 | 0.702949 | 6 | 0 | 5 |
| UNC5C | GIMAP1 | 0.701172 | 5 | 0 | 4 |
| UNC5C | VSTM4 | 0.70045 | 7 | 0 | 5 |
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