| Full name: cell division cycle 40 | Alias Symbol: PRP17|EHB3|PRPF17|FLJ10564 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 51362 | HGNC ID: HGNC:17350 | Ensembl Gene: ENSG00000168438 | OMIM ID: 605585 |
| Drug and gene relationship at DGIdb | |||
Expression of CDC40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC40 | 51362 | 203376_at | -0.4048 | 0.3036 | |
| GSE20347 | CDC40 | 51362 | 203376_at | -0.1003 | 0.5248 | |
| GSE23400 | CDC40 | 51362 | 203376_at | 0.0148 | 0.7801 | |
| GSE26886 | CDC40 | 51362 | 203376_at | 0.2035 | 0.4434 | |
| GSE29001 | CDC40 | 51362 | 203376_at | 0.1727 | 0.5394 | |
| GSE38129 | CDC40 | 51362 | 203376_at | -0.0050 | 0.9695 | |
| GSE45670 | CDC40 | 51362 | 203376_at | -0.1509 | 0.2563 | |
| GSE53622 | CDC40 | 51362 | 31902 | -0.0541 | 0.5049 | |
| GSE53624 | CDC40 | 51362 | 33171 | -0.0803 | 0.2980 | |
| GSE63941 | CDC40 | 51362 | 203376_at | -0.3106 | 0.3990 | |
| GSE77861 | CDC40 | 51362 | 203376_at | -0.0446 | 0.8684 | |
| GSE97050 | CDC40 | 51362 | A_23_P351320 | 0.0283 | 0.9402 | |
| SRP007169 | CDC40 | 51362 | RNAseq | 0.5937 | 0.0980 | |
| SRP008496 | CDC40 | 51362 | RNAseq | 0.6674 | 0.0113 | |
| SRP064894 | CDC40 | 51362 | RNAseq | -0.0629 | 0.7605 | |
| SRP133303 | CDC40 | 51362 | RNAseq | -0.0954 | 0.3670 | |
| SRP159526 | CDC40 | 51362 | RNAseq | -0.0794 | 0.7755 | |
| SRP193095 | CDC40 | 51362 | RNAseq | -0.3749 | 0.0000 | |
| SRP219564 | CDC40 | 51362 | RNAseq | -0.2306 | 0.4608 | |
| TCGA | CDC40 | 51362 | RNAseq | -0.0668 | 0.1879 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDC40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC40 | 51362 | 2 | 3 | 25 | |
| GSE20123 | CDC40 | 51362 | 2 | 2 | 26 | |
| GSE43470 | CDC40 | 51362 | 3 | 1 | 39 | |
| GSE46452 | CDC40 | 51362 | 2 | 11 | 46 | |
| GSE47630 | CDC40 | 51362 | 9 | 4 | 27 | |
| GSE54993 | CDC40 | 51362 | 3 | 2 | 65 | |
| GSE54994 | CDC40 | 51362 | 8 | 8 | 37 | |
| GSE60625 | CDC40 | 51362 | 0 | 2 | 9 | |
| GSE74703 | CDC40 | 51362 | 2 | 1 | 33 | |
| GSE74704 | CDC40 | 51362 | 0 | 0 | 20 | |
| TCGA | CDC40 | 51362 | 6 | 23 | 67 |
Total number of gains: 37; Total number of losses: 57; Total Number of normals: 394.
Somatic mutations of CDC40:
Generating mutation plots.
Highly correlated genes for CDC40:
Showing top 20/589 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC40 | RAPGEF6 | 0.794898 | 3 | 0 | 3 |
| CDC40 | ZNF709 | 0.76763 | 3 | 0 | 3 |
| CDC40 | RPS6KB1 | 0.765067 | 3 | 0 | 3 |
| CDC40 | SCML1 | 0.754392 | 3 | 0 | 3 |
| CDC40 | BLOC1S2 | 0.744739 | 3 | 0 | 3 |
| CDC40 | TCEA1 | 0.738035 | 3 | 0 | 3 |
| CDC40 | TACO1 | 0.735869 | 3 | 0 | 3 |
| CDC40 | STAMBPL1 | 0.729364 | 3 | 0 | 3 |
| CDC40 | AXL | 0.72894 | 3 | 0 | 3 |
| CDC40 | TYW3 | 0.727179 | 4 | 0 | 4 |
| CDC40 | CRBN | 0.725718 | 3 | 0 | 3 |
| CDC40 | NSRP1 | 0.723946 | 4 | 0 | 4 |
| CDC40 | FAM118B | 0.717569 | 3 | 0 | 3 |
| CDC40 | LNPEP | 0.716708 | 3 | 0 | 3 |
| CDC40 | TRUB1 | 0.71551 | 3 | 0 | 3 |
| CDC40 | MTMR6 | 0.710784 | 4 | 0 | 3 |
| CDC40 | FBXO9 | 0.70626 | 3 | 0 | 3 |
| CDC40 | TMEM126B | 0.705802 | 4 | 0 | 4 |
| CDC40 | SNX30 | 0.705644 | 3 | 0 | 3 |
| CDC40 | SPRED1 | 0.701196 | 3 | 0 | 3 |
For details and further investigation, click here
