| Full name: death associated protein kinase 1 | Alias Symbol: DAPK|ROCO3 | ||
| Type: protein-coding gene | Cytoband: 9q21.33 | ||
| Entrez ID: 1612 | HGNC ID: HGNC:2674 | Ensembl Gene: ENSG00000196730 | OMIM ID: 600831 |
| Drug and gene relationship at DGIdb | |||
DAPK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05219 | Bladder cancer |
Expression of DAPK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAPK1 | 1612 | 203139_at | -0.8553 | 0.4486 | |
| GSE20347 | DAPK1 | 1612 | 203139_at | 0.1209 | 0.7102 | |
| GSE23400 | DAPK1 | 1612 | 203139_at | -0.1528 | 0.3450 | |
| GSE26886 | DAPK1 | 1612 | 203139_at | 0.8397 | 0.1678 | |
| GSE29001 | DAPK1 | 1612 | 203139_at | 0.3679 | 0.3010 | |
| GSE38129 | DAPK1 | 1612 | 203139_at | -0.3514 | 0.3691 | |
| GSE45670 | DAPK1 | 1612 | 203139_at | -0.9135 | 0.0248 | |
| GSE53622 | DAPK1 | 1612 | 40202 | -0.1167 | 0.0818 | |
| GSE53624 | DAPK1 | 1612 | 40202 | -0.0900 | 0.1614 | |
| GSE63941 | DAPK1 | 1612 | 203139_at | -1.6314 | 0.1615 | |
| GSE77861 | DAPK1 | 1612 | 203139_at | 0.0292 | 0.8965 | |
| GSE97050 | DAPK1 | 1612 | A_33_P3737504 | -0.2774 | 0.3946 | |
| SRP007169 | DAPK1 | 1612 | RNAseq | 2.5783 | 0.0002 | |
| SRP008496 | DAPK1 | 1612 | RNAseq | 2.0252 | 0.0001 | |
| SRP064894 | DAPK1 | 1612 | RNAseq | 0.2631 | 0.3955 | |
| SRP133303 | DAPK1 | 1612 | RNAseq | 0.0758 | 0.7719 | |
| SRP159526 | DAPK1 | 1612 | RNAseq | 0.7418 | 0.2097 | |
| SRP193095 | DAPK1 | 1612 | RNAseq | -0.3067 | 0.3970 | |
| SRP219564 | DAPK1 | 1612 | RNAseq | 0.1470 | 0.8369 | |
| TCGA | DAPK1 | 1612 | RNAseq | -0.6669 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DAPK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DAPK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAPK1 | 1612 | 5 | 10 | 15 | |
| GSE20123 | DAPK1 | 1612 | 5 | 10 | 15 | |
| GSE43470 | DAPK1 | 1612 | 6 | 3 | 34 | |
| GSE46452 | DAPK1 | 1612 | 6 | 14 | 39 | |
| GSE47630 | DAPK1 | 1612 | 1 | 18 | 21 | |
| GSE54993 | DAPK1 | 1612 | 4 | 2 | 64 | |
| GSE54994 | DAPK1 | 1612 | 6 | 11 | 36 | |
| GSE60625 | DAPK1 | 1612 | 0 | 0 | 11 | |
| GSE74703 | DAPK1 | 1612 | 5 | 3 | 28 | |
| GSE74704 | DAPK1 | 1612 | 3 | 7 | 10 | |
| TCGA | DAPK1 | 1612 | 20 | 27 | 49 |
Total number of gains: 61; Total number of losses: 105; Total Number of normals: 322.
Somatic mutations of DAPK1:
Generating mutation plots.
Highly correlated genes for DAPK1:
Showing top 20/822 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAPK1 | FILIP1 | 0.776849 | 3 | 0 | 3 |
| DAPK1 | XKR4 | 0.753163 | 3 | 0 | 3 |
| DAPK1 | DIAPH2 | 0.750893 | 4 | 0 | 4 |
| DAPK1 | BHLHE22 | 0.748497 | 3 | 0 | 3 |
| DAPK1 | AXL | 0.740332 | 6 | 0 | 5 |
| DAPK1 | DPT | 0.73738 | 5 | 0 | 5 |
| DAPK1 | GNG11 | 0.7343 | 6 | 0 | 6 |
| DAPK1 | SMTN | 0.728899 | 4 | 0 | 4 |
| DAPK1 | CPE | 0.723593 | 5 | 0 | 5 |
| DAPK1 | CALD1 | 0.722132 | 5 | 0 | 5 |
| DAPK1 | INPP5A | 0.718411 | 4 | 0 | 4 |
| DAPK1 | CHN2 | 0.718071 | 3 | 0 | 3 |
| DAPK1 | RUNX1T1 | 0.716092 | 5 | 0 | 4 |
| DAPK1 | ADARB1 | 0.715862 | 6 | 0 | 5 |
| DAPK1 | THAP8 | 0.713793 | 3 | 0 | 3 |
| DAPK1 | LRRN4CL | 0.709036 | 4 | 0 | 3 |
| DAPK1 | ZER1 | 0.708907 | 3 | 0 | 3 |
| DAPK1 | KCTD12 | 0.708438 | 6 | 0 | 6 |
| DAPK1 | TAGLN | 0.706652 | 5 | 0 | 5 |
| DAPK1 | KBTBD11 | 0.704182 | 4 | 0 | 3 |
For details and further investigation, click here
