| Full name: calcium voltage-gated channel auxiliary subunit alpha2delta 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 93589 | HGNC ID: HGNC:20202 | Ensembl Gene: ENSG00000151062 | OMIM ID: 608171 |
| Drug and gene relationship at DGIdb | |||
CACNA2D4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNA2D4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA2D4 | 93589 | 228083_at | -0.1656 | 0.6118 | |
| GSE26886 | CACNA2D4 | 93589 | 228083_at | 0.1552 | 0.3098 | |
| GSE45670 | CACNA2D4 | 93589 | 1552690_a_at | -0.0691 | 0.5037 | |
| GSE53622 | CACNA2D4 | 93589 | 94771 | -0.1158 | 0.1497 | |
| GSE53624 | CACNA2D4 | 93589 | 94771 | 0.0672 | 0.5256 | |
| GSE63941 | CACNA2D4 | 93589 | 1552690_a_at | 0.0064 | 0.9715 | |
| GSE77861 | CACNA2D4 | 93589 | 1552690_a_at | -0.0736 | 0.4766 | |
| GSE97050 | CACNA2D4 | 93589 | A_23_P353014 | 0.0312 | 0.8840 | |
| SRP064894 | CACNA2D4 | 93589 | RNAseq | 0.7453 | 0.0273 | |
| SRP133303 | CACNA2D4 | 93589 | RNAseq | -0.1254 | 0.5874 | |
| SRP159526 | CACNA2D4 | 93589 | RNAseq | -0.9617 | 0.0285 | |
| SRP193095 | CACNA2D4 | 93589 | RNAseq | -0.4169 | 0.0422 | |
| SRP219564 | CACNA2D4 | 93589 | RNAseq | 0.3961 | 0.3298 | |
| TCGA | CACNA2D4 | 93589 | RNAseq | -0.3167 | 0.1043 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CACNA2D4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA2D4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA2D4 | 93589 | 7 | 4 | 19 | |
| GSE20123 | CACNA2D4 | 93589 | 7 | 4 | 19 | |
| GSE43470 | CACNA2D4 | 93589 | 11 | 3 | 29 | |
| GSE46452 | CACNA2D4 | 93589 | 10 | 1 | 48 | |
| GSE47630 | CACNA2D4 | 93589 | 12 | 2 | 26 | |
| GSE54993 | CACNA2D4 | 93589 | 1 | 10 | 59 | |
| GSE54994 | CACNA2D4 | 93589 | 10 | 2 | 41 | |
| GSE60625 | CACNA2D4 | 93589 | 0 | 1 | 10 | |
| GSE74703 | CACNA2D4 | 93589 | 10 | 2 | 24 | |
| GSE74704 | CACNA2D4 | 93589 | 4 | 2 | 14 | |
| TCGA | CACNA2D4 | 93589 | 40 | 6 | 50 |
Total number of gains: 112; Total number of losses: 37; Total Number of normals: 339.
Somatic mutations of CACNA2D4:
Generating mutation plots.
Highly correlated genes for CACNA2D4:
Showing top 20/193 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA2D4 | CTSO | 0.791638 | 3 | 0 | 3 |
| CACNA2D4 | SLC15A3 | 0.757585 | 3 | 0 | 3 |
| CACNA2D4 | ME2 | 0.754333 | 3 | 0 | 3 |
| CACNA2D4 | ZDHHC14 | 0.740451 | 3 | 0 | 3 |
| CACNA2D4 | AXL | 0.734656 | 3 | 0 | 3 |
| CACNA2D4 | GNG7 | 0.725829 | 4 | 0 | 3 |
| CACNA2D4 | KCNAB2 | 0.724773 | 3 | 0 | 3 |
| CACNA2D4 | MRC2 | 0.713442 | 3 | 0 | 3 |
| CACNA2D4 | CLDN18 | 0.712471 | 3 | 0 | 3 |
| CACNA2D4 | HVCN1 | 0.710923 | 3 | 0 | 3 |
| CACNA2D4 | HSD11B1 | 0.706028 | 3 | 0 | 3 |
| CACNA2D4 | PRKAR2B | 0.705571 | 3 | 0 | 3 |
| CACNA2D4 | GPRASP1 | 0.70542 | 3 | 0 | 3 |
| CACNA2D4 | ERCC2 | 0.697609 | 3 | 0 | 3 |
| CACNA2D4 | ADAMTS8 | 0.696885 | 3 | 0 | 3 |
| CACNA2D4 | PRKG1 | 0.694688 | 3 | 0 | 3 |
| CACNA2D4 | HGF | 0.692435 | 4 | 0 | 3 |
| CACNA2D4 | ARHGEF6 | 0.691022 | 4 | 0 | 3 |
| CACNA2D4 | TMSB4Y | 0.690939 | 4 | 0 | 3 |
| CACNA2D4 | ADH1A | 0.688411 | 3 | 0 | 3 |
For details and further investigation, click here
