| Full name: calcium voltage-gated channel subunit alpha1 B | Alias Symbol: Cav2.2|CACNN | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 774 | HGNC ID: HGNC:1389 | Ensembl Gene: ENSG00000148408 | OMIM ID: 601012 |
| Related drugs: AMLODIPINE, ATAGABALIN, BEPRIDIL HYDROCHLORIDE, CHEMBL157769, CILNIDIPINE, CLEVIDIPINE, CNV2197944, ELPETRIGINE, GABAPENTIN, GABAPENTIN ENACARBIL... [more] | |||
CACNA1B involved pathways:
Expression of CACNA1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA1B | 774 | 207162_s_at | 0.2435 | 0.4454 | |
| GSE20347 | CACNA1B | 774 | 207162_s_at | -0.1853 | 0.0096 | |
| GSE23400 | CACNA1B | 774 | 207162_s_at | -0.1216 | 0.0313 | |
| GSE26886 | CACNA1B | 774 | 207162_s_at | 0.1236 | 0.4210 | |
| GSE29001 | CACNA1B | 774 | 207162_s_at | 0.0184 | 0.9237 | |
| GSE38129 | CACNA1B | 774 | 207162_s_at | -0.0876 | 0.4497 | |
| GSE45670 | CACNA1B | 774 | 235781_at | 0.7351 | 0.0358 | |
| GSE53622 | CACNA1B | 774 | 39664 | -0.1814 | 0.1528 | |
| GSE53624 | CACNA1B | 774 | 39664 | -0.0835 | 0.4336 | |
| GSE63941 | CACNA1B | 774 | 207162_s_at | 0.0263 | 0.8720 | |
| GSE77861 | CACNA1B | 774 | 207162_s_at | 0.2071 | 0.5127 | |
| GSE97050 | CACNA1B | 774 | A_33_P3280099 | -0.0536 | 0.8515 | |
| SRP133303 | CACNA1B | 774 | RNAseq | 2.5838 | 0.0000 | |
| SRP159526 | CACNA1B | 774 | RNAseq | 6.0900 | 0.0000 | |
| SRP219564 | CACNA1B | 774 | RNAseq | 3.9849 | 0.0000 | |
| TCGA | CACNA1B | 774 | RNAseq | 1.4890 | 0.0012 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CACNA1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA1B | 774 | 6 | 6 | 18 | |
| GSE20123 | CACNA1B | 774 | 6 | 6 | 18 | |
| GSE43470 | CACNA1B | 774 | 3 | 7 | 33 | |
| GSE46452 | CACNA1B | 774 | 6 | 13 | 40 | |
| GSE47630 | CACNA1B | 774 | 6 | 15 | 19 | |
| GSE54993 | CACNA1B | 774 | 3 | 3 | 64 | |
| GSE54994 | CACNA1B | 774 | 19 | 3 | 31 | |
| GSE60625 | CACNA1B | 774 | 0 | 0 | 11 | |
| GSE74703 | CACNA1B | 774 | 3 | 5 | 28 | |
| GSE74704 | CACNA1B | 774 | 3 | 4 | 13 | |
| TCGA | CACNA1B | 774 | 29 | 23 | 44 |
Total number of gains: 84; Total number of losses: 85; Total Number of normals: 319.
Somatic mutations of CACNA1B:
Generating mutation plots.
Highly correlated genes for CACNA1B:
Showing top 20/296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA1B | CRYBB2 | 0.801697 | 3 | 0 | 3 |
| CACNA1B | NADK | 0.776343 | 3 | 0 | 3 |
| CACNA1B | RLIM | 0.775193 | 3 | 0 | 3 |
| CACNA1B | HNRNPUL1 | 0.766482 | 3 | 0 | 3 |
| CACNA1B | KCNAB2 | 0.75511 | 3 | 0 | 3 |
| CACNA1B | QSOX2 | 0.749284 | 3 | 0 | 3 |
| CACNA1B | STK32B | 0.747378 | 3 | 0 | 3 |
| CACNA1B | ZNF284 | 0.746776 | 3 | 0 | 3 |
| CACNA1B | FOXP4 | 0.73715 | 3 | 0 | 3 |
| CACNA1B | INPP5E | 0.736302 | 3 | 0 | 3 |
| CACNA1B | PTOV1 | 0.734821 | 3 | 0 | 3 |
| CACNA1B | NAA30 | 0.733877 | 3 | 0 | 3 |
| CACNA1B | ZNF830 | 0.73282 | 3 | 0 | 3 |
| CACNA1B | RPLP2 | 0.732769 | 3 | 0 | 3 |
| CACNA1B | LMO1 | 0.730496 | 4 | 0 | 3 |
| CACNA1B | ZNF581 | 0.729713 | 3 | 0 | 3 |
| CACNA1B | MRPL47 | 0.729572 | 3 | 0 | 3 |
| CACNA1B | GYS1 | 0.728445 | 3 | 0 | 3 |
| CACNA1B | ENPP5 | 0.723791 | 3 | 0 | 3 |
| CACNA1B | TRAF6 | 0.716506 | 3 | 0 | 3 |
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