Full name: TNF receptor associated factor 6	Alias Symbol: RNF85
Type: protein-coding gene	Cytoband: 11p12
Entrez ID: 7189	HGNC ID: HGNC:12036	Ensembl Gene: ENSG00000175104	OMIM ID: 602355
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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TRAF6 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04064	NF-kappa B signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04622	RIG-I-like receptor signaling pathway	View
hsa04722	Neurotrophin signaling pathway	View
hsa05133	Pertussis	View
hsa05140	Leishmaniasis	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05152	Tuberculosis	View
hsa05160	Hepatitis C	View
hsa05162	Measles	View
hsa05168	Herpes simplex infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05222	Small cell lung cancer	View

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Expression of TRAF6:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	TRAF6	7189	205558_at	-0.4902	0.0386	Show
GSE20347	TRAF6	7189	205558_at	-0.2911	0.0113	Show
GSE23400	TRAF6	7189	205558_at	-0.0320	0.4210	Show
GSE26886	TRAF6	7189	205558_at	-0.3777	0.0283	Show
GSE29001	TRAF6	7189	205558_at	-0.2625	0.1106	Show
GSE38129	TRAF6	7189	205558_at	-0.2620	0.0037	Show
GSE45670	TRAF6	7189	205558_at	-0.0482	0.7793	Show
GSE53622	TRAF6	7189	30203	-0.4948	0.0000	Show
GSE53624	TRAF6	7189	30203	-0.4103	0.0000	Show
GSE63941	TRAF6	7189	205558_at	0.3391	0.3132	Show
GSE77861	TRAF6	7189	205558_at	-0.0502	0.7749	Show
GSE97050	TRAF6	7189	A_23_P75921	-0.1854	0.4638	Show
SRP007169	TRAF6	7189	RNAseq	0.2260	0.6232	Show
SRP008496	TRAF6	7189	RNAseq	0.4496	0.1446	Show
SRP064894	TRAF6	7189	RNAseq	-0.3582	0.0265	Show
SRP133303	TRAF6	7189	RNAseq	-0.1324	0.5159	Show
SRP159526	TRAF6	7189	RNAseq	-0.7453	0.0049	Show
SRP193095	TRAF6	7189	RNAseq	-0.5432	0.0000	Show
SRP219564	TRAF6	7189	RNAseq	-0.0044	0.9882	Show
TCGA	TRAF6	7189	RNAseq	-0.1413	0.0213	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by TRAF6 expression:

 

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Copy number change of TRAF6:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	TRAF6	7189	0	9	21	Show
GSE20123	TRAF6	7189	0	8	22	Show
GSE43470	TRAF6	7189	3	4	36	Show
GSE46452	TRAF6	7189	7	5	47	Show
GSE47630	TRAF6	7189	3	10	27	Show
GSE54993	TRAF6	7189	3	2	65	Show
GSE54994	TRAF6	7189	3	10	40	Show
GSE60625	TRAF6	7189	0	0	11	Show
GSE74703	TRAF6	7189	2	2	32	Show
GSE74704	TRAF6	7189	0	6	14	Show
TCGA	TRAF6	7189	13	22	61	Show

Total number of gains: 34; Total number of losses: 78; Total Number of normals: 376.  Download Data

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Somatic mutations of TRAF6:

 

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Highly correlated genes for TRAF6:

 

Showing top 20/636 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
TRAF6	FMO3	0.78609	3	0	3
TRAF6	PEX19	0.770315	3	0	3
TRAF6	KDM5D	0.768889	3	0	3
TRAF6	EIF1AY	0.766505	3	0	3
TRAF6	MCTS1	0.763345	3	0	3
TRAF6	MID1IP1	0.751404	3	0	3
TRAF6	CACNA1B	0.716506	3	0	3
TRAF6	ZNF564	0.709426	3	0	3
TRAF6	EXOC2	0.709188	4	0	4
TRAF6	PHYHD1	0.703255	4	0	4
TRAF6	ALKBH3	0.703041	3	0	3
TRAF6	HLA-E	0.701938	3	0	3
TRAF6	CPEB4	0.692098	5	0	5
TRAF6	TMEM167B	0.690797	3	0	3
TRAF6	CAPNS2	0.687781	4	0	4
TRAF6	ZNF844	0.684596	4	0	4
TRAF6	KLHL2	0.68393	5	0	5
TRAF6	MTMR10	0.681733	5	0	4
TRAF6	ZBTB1	0.679017	3	0	3
TRAF6	AK3	0.678189	6	0	6

For details and further investigation, click here