| Full name: calcium voltage-gated channel subunit alpha1 I | Alias Symbol: Cav3.3 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 8911 | HGNC ID: HGNC:1396 | Ensembl Gene: ENSG00000100346 | OMIM ID: 608230 |
| Drug and gene relationship at DGIdb | |||
CACNA1I involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04020 | Calcium signaling pathway | |
| hsa04713 | Circadian entrainment |
Expression of CACNA1I:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA1I | 8911 | 211830_s_at | -0.0450 | 0.9037 | |
| GSE20347 | CACNA1I | 8911 | 211830_s_at | -0.0074 | 0.9322 | |
| GSE23400 | CACNA1I | 8911 | 211830_s_at | -0.0909 | 0.0395 | |
| GSE26886 | CACNA1I | 8911 | 208299_at | 0.3427 | 0.0251 | |
| GSE29001 | CACNA1I | 8911 | 221631_at | 0.0219 | 0.9144 | |
| GSE38129 | CACNA1I | 8911 | 211830_s_at | -0.0857 | 0.2260 | |
| GSE45670 | CACNA1I | 8911 | 208299_at | -0.1306 | 0.1551 | |
| GSE53622 | CACNA1I | 8911 | 89123 | 0.1112 | 0.1524 | |
| GSE53624 | CACNA1I | 8911 | 89123 | 0.1457 | 0.1517 | |
| GSE63941 | CACNA1I | 8911 | 211830_s_at | 0.2483 | 0.1181 | |
| GSE77861 | CACNA1I | 8911 | 211830_s_at | -0.0293 | 0.7957 | |
| GSE97050 | CACNA1I | 8911 | A_33_P3350566 | 0.1143 | 0.6887 | |
| SRP133303 | CACNA1I | 8911 | RNAseq | 0.2419 | 0.5958 | |
| SRP159526 | CACNA1I | 8911 | RNAseq | 1.9651 | 0.0112 | |
| SRP219564 | CACNA1I | 8911 | RNAseq | -0.8895 | 0.1482 | |
| TCGA | CACNA1I | 8911 | RNAseq | -0.1098 | 0.8345 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CACNA1I expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA1I:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA1I | 8911 | 6 | 5 | 19 | |
| GSE20123 | CACNA1I | 8911 | 6 | 4 | 20 | |
| GSE43470 | CACNA1I | 8911 | 5 | 7 | 31 | |
| GSE46452 | CACNA1I | 8911 | 31 | 2 | 26 | |
| GSE47630 | CACNA1I | 8911 | 9 | 4 | 27 | |
| GSE54993 | CACNA1I | 8911 | 3 | 6 | 61 | |
| GSE54994 | CACNA1I | 8911 | 10 | 7 | 36 | |
| GSE60625 | CACNA1I | 8911 | 5 | 0 | 6 | |
| GSE74703 | CACNA1I | 8911 | 5 | 5 | 26 | |
| GSE74704 | CACNA1I | 8911 | 3 | 2 | 15 | |
| TCGA | CACNA1I | 8911 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 57; Total Number of normals: 321.
Somatic mutations of CACNA1I:
Generating mutation plots.
Highly correlated genes for CACNA1I:
Showing top 20/599 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA1I | ZNF527 | 0.754985 | 3 | 0 | 3 |
| CACNA1I | TM6SF2 | 0.752385 | 3 | 0 | 3 |
| CACNA1I | CLEC4G | 0.752334 | 3 | 0 | 3 |
| CACNA1I | TSPAN11 | 0.732969 | 3 | 0 | 3 |
| CACNA1I | KRTAP9-9 | 0.730426 | 3 | 0 | 3 |
| CACNA1I | RAD52 | 0.72571 | 3 | 0 | 3 |
| CACNA1I | TXNDC2 | 0.716097 | 4 | 0 | 4 |
| CACNA1I | C20orf85 | 0.714871 | 4 | 0 | 3 |
| CACNA1I | CDRT15 | 0.714787 | 5 | 0 | 4 |
| CACNA1I | ASPHD1 | 0.712498 | 3 | 0 | 3 |
| CACNA1I | FAM131A | 0.712001 | 4 | 0 | 4 |
| CACNA1I | FMR1NB | 0.7117 | 3 | 0 | 3 |
| CACNA1I | BRSK1 | 0.697919 | 4 | 0 | 4 |
| CACNA1I | YJEFN3 | 0.696647 | 3 | 0 | 3 |
| CACNA1I | OR7C1 | 0.686265 | 3 | 0 | 3 |
| CACNA1I | STAC3 | 0.682028 | 4 | 0 | 3 |
| CACNA1I | SPRED3 | 0.680057 | 4 | 0 | 3 |
| CACNA1I | DNAI1 | 0.678971 | 4 | 0 | 3 |
| CACNA1I | FFAR1 | 0.677812 | 4 | 0 | 3 |
| CACNA1I | TMEM151A | 0.677024 | 5 | 0 | 4 |
For details and further investigation, click here
