| Full name: BR serine/threonine kinase 1 | Alias Symbol: KIAA1811 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 84446 | HGNC ID: HGNC:18994 | Ensembl Gene: ENSG00000160469 | OMIM ID: 609235 |
| Drug and gene relationship at DGIdb | |||
Expression of BRSK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRSK1 | 84446 | 1552504_a_at | 0.0073 | 0.9862 | |
| GSE26886 | BRSK1 | 84446 | 1552504_a_at | 0.3852 | 0.0096 | |
| GSE45670 | BRSK1 | 84446 | 1552504_a_at | 0.0069 | 0.9622 | |
| GSE63941 | BRSK1 | 84446 | 1552504_a_at | 0.4260 | 0.0196 | |
| GSE77861 | BRSK1 | 84446 | 1552504_a_at | -0.1222 | 0.2172 | |
| GSE97050 | BRSK1 | 84446 | A_23_P89973 | -0.0611 | 0.8243 | |
| SRP064894 | BRSK1 | 84446 | RNAseq | 0.4298 | 0.0767 | |
| SRP133303 | BRSK1 | 84446 | RNAseq | 0.2196 | 0.5195 | |
| SRP159526 | BRSK1 | 84446 | RNAseq | 1.4139 | 0.0163 | |
| SRP193095 | BRSK1 | 84446 | RNAseq | 1.5255 | 0.0000 | |
| SRP219564 | BRSK1 | 84446 | RNAseq | -0.2011 | 0.7802 | |
| TCGA | BRSK1 | 84446 | RNAseq | 0.1323 | 0.6242 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by BRSK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BRSK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRSK1 | 84446 | 3 | 4 | 23 | |
| GSE20123 | BRSK1 | 84446 | 3 | 3 | 24 | |
| GSE43470 | BRSK1 | 84446 | 3 | 11 | 29 | |
| GSE46452 | BRSK1 | 84446 | 45 | 1 | 13 | |
| GSE47630 | BRSK1 | 84446 | 8 | 6 | 26 | |
| GSE54993 | BRSK1 | 84446 | 17 | 4 | 49 | |
| GSE54994 | BRSK1 | 84446 | 4 | 13 | 36 | |
| GSE60625 | BRSK1 | 84446 | 9 | 0 | 2 | |
| GSE74703 | BRSK1 | 84446 | 3 | 7 | 26 | |
| GSE74704 | BRSK1 | 84446 | 3 | 1 | 16 | |
| TCGA | BRSK1 | 84446 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of BRSK1:
Generating mutation plots.
Highly correlated genes for BRSK1:
Showing top 20/211 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRSK1 | EDA | 0.77992 | 3 | 0 | 3 |
| BRSK1 | OTUD5 | 0.777799 | 3 | 0 | 3 |
| BRSK1 | EVX1 | 0.758118 | 3 | 0 | 3 |
| BRSK1 | CPLX2 | 0.725894 | 3 | 0 | 3 |
| BRSK1 | LAT | 0.721215 | 3 | 0 | 3 |
| BRSK1 | CHRD | 0.721045 | 3 | 0 | 3 |
| BRSK1 | FASLG | 0.717949 | 3 | 0 | 3 |
| BRSK1 | C20orf141 | 0.717204 | 4 | 0 | 3 |
| BRSK1 | SSTR2 | 0.714794 | 3 | 0 | 3 |
| BRSK1 | POLM | 0.71339 | 3 | 0 | 3 |
| BRSK1 | FAM178B | 0.708084 | 3 | 0 | 3 |
| BRSK1 | CABP4 | 0.707404 | 4 | 0 | 3 |
| BRSK1 | ZNF524 | 0.703729 | 3 | 0 | 3 |
| BRSK1 | ZFHX2 | 0.703179 | 3 | 0 | 3 |
| BRSK1 | CACNA1I | 0.697919 | 4 | 0 | 4 |
| BRSK1 | LGR6 | 0.69548 | 3 | 0 | 3 |
| BRSK1 | ERCC5 | 0.695446 | 3 | 0 | 3 |
| BRSK1 | WNT1 | 0.693008 | 3 | 0 | 3 |
| BRSK1 | PRLH | 0.692674 | 4 | 0 | 4 |
| BRSK1 | GRAP | 0.692079 | 3 | 0 | 3 |
For details and further investigation, click here
