| Full name: transmembrane 6 superfamily member 2 | Alias Symbol: Lpr4 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 53345 | HGNC ID: HGNC:11861 | Ensembl Gene: ENSG00000213996 | OMIM ID: 606563 |
| Drug and gene relationship at DGIdb | |||
Expression of TM6SF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TM6SF2 | 53345 | 233403_x_at | 0.0784 | 0.7634 | |
| GSE20347 | TM6SF2 | 53345 | 216736_at | -0.1084 | 0.1847 | |
| GSE23400 | TM6SF2 | 53345 | 216736_at | -0.1878 | 0.0000 | |
| GSE26886 | TM6SF2 | 53345 | 233403_x_at | 0.1093 | 0.4159 | |
| GSE29001 | TM6SF2 | 53345 | 216736_at | -0.3899 | 0.0119 | |
| GSE38129 | TM6SF2 | 53345 | 216736_at | -0.2132 | 0.0537 | |
| GSE45670 | TM6SF2 | 53345 | 233403_x_at | 0.0913 | 0.3471 | |
| GSE63941 | TM6SF2 | 53345 | 233403_x_at | 0.2577 | 0.1266 | |
| GSE77861 | TM6SF2 | 53345 | 233403_x_at | -0.0389 | 0.7446 | |
| GSE97050 | TM6SF2 | 53345 | A_23_P142403 | 0.1609 | 0.4736 | |
| SRP064894 | TM6SF2 | 53345 | RNAseq | 3.0081 | 0.0000 | |
| SRP219564 | TM6SF2 | 53345 | RNAseq | 2.3846 | 0.0000 | |
| TCGA | TM6SF2 | 53345 | RNAseq | -0.3219 | 0.4842 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TM6SF2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TM6SF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TM6SF2 | 53345 | 4 | 5 | 21 | |
| GSE20123 | TM6SF2 | 53345 | 3 | 3 | 24 | |
| GSE43470 | TM6SF2 | 53345 | 2 | 5 | 36 | |
| GSE46452 | TM6SF2 | 53345 | 47 | 1 | 11 | |
| GSE47630 | TM6SF2 | 53345 | 5 | 8 | 27 | |
| GSE54993 | TM6SF2 | 53345 | 16 | 4 | 50 | |
| GSE54994 | TM6SF2 | 53345 | 6 | 13 | 34 | |
| GSE60625 | TM6SF2 | 53345 | 9 | 0 | 2 | |
| GSE74703 | TM6SF2 | 53345 | 2 | 3 | 31 | |
| GSE74704 | TM6SF2 | 53345 | 0 | 3 | 17 | |
| TCGA | TM6SF2 | 53345 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of TM6SF2:
Generating mutation plots.
Highly correlated genes for TM6SF2:
Showing top 20/849 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TM6SF2 | SCUBE1 | 0.802712 | 3 | 0 | 3 |
| TM6SF2 | SPTBN5 | 0.769798 | 4 | 0 | 3 |
| TM6SF2 | REG3A | 0.765503 | 4 | 0 | 4 |
| TM6SF2 | RALYL | 0.758411 | 3 | 0 | 3 |
| TM6SF2 | PGC | 0.754979 | 3 | 0 | 3 |
| TM6SF2 | TMEM235 | 0.754236 | 3 | 0 | 3 |
| TM6SF2 | CACNA1I | 0.752385 | 3 | 0 | 3 |
| TM6SF2 | LRFN2 | 0.749245 | 3 | 0 | 3 |
| TM6SF2 | USHBP1 | 0.746338 | 3 | 0 | 3 |
| TM6SF2 | MIIP | 0.745408 | 3 | 0 | 3 |
| TM6SF2 | DNAJB8 | 0.742378 | 3 | 0 | 3 |
| TM6SF2 | ZKSCAN2 | 0.738734 | 3 | 0 | 3 |
| TM6SF2 | NPEPL1 | 0.738722 | 5 | 0 | 5 |
| TM6SF2 | SLC25A47 | 0.731236 | 3 | 0 | 3 |
| TM6SF2 | DUX1 | 0.729631 | 5 | 0 | 5 |
| TM6SF2 | GNB3 | 0.722755 | 4 | 0 | 4 |
| TM6SF2 | NLRP5 | 0.722381 | 3 | 0 | 3 |
| TM6SF2 | PALM3 | 0.722126 | 3 | 0 | 3 |
| TM6SF2 | FMR1NB | 0.721517 | 3 | 0 | 3 |
| TM6SF2 | CRHR2 | 0.720191 | 3 | 0 | 3 |
For details and further investigation, click here
