| Full name: cyclin dependent kinase 5 regulatory subunit 2 | Alias Symbol: p39nck5ai|P39|NCK5AI | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 8941 | HGNC ID: HGNC:1776 | Ensembl Gene: ENSG00000171450 | OMIM ID: 603764 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK5R2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK5R2 | 8941 | 205852_at | -0.0674 | 0.7460 | |
| GSE20347 | CDK5R2 | 8941 | 205852_at | 0.0312 | 0.6577 | |
| GSE23400 | CDK5R2 | 8941 | 205852_at | -0.0285 | 0.2896 | |
| GSE26886 | CDK5R2 | 8941 | 205852_at | 0.1483 | 0.2514 | |
| GSE29001 | CDK5R2 | 8941 | 205852_at | 0.0903 | 0.5800 | |
| GSE38129 | CDK5R2 | 8941 | 205852_at | -0.0071 | 0.9181 | |
| GSE45670 | CDK5R2 | 8941 | 205852_at | 0.0774 | 0.5106 | |
| GSE53622 | CDK5R2 | 8941 | 78725 | 0.3219 | 0.0016 | |
| GSE53624 | CDK5R2 | 8941 | 78725 | 0.3180 | 0.0009 | |
| GSE63941 | CDK5R2 | 8941 | 205852_at | 0.0444 | 0.8300 | |
| GSE77861 | CDK5R2 | 8941 | 205852_at | -0.0729 | 0.4313 | |
| GSE97050 | CDK5R2 | 8941 | A_24_P51683 | 0.0489 | 0.8338 | |
| TCGA | CDK5R2 | 8941 | RNAseq | -1.5686 | 0.0070 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CDK5R2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK5R2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK5R2 | 8941 | 1 | 14 | 15 | |
| GSE20123 | CDK5R2 | 8941 | 1 | 13 | 16 | |
| GSE43470 | CDK5R2 | 8941 | 1 | 7 | 35 | |
| GSE46452 | CDK5R2 | 8941 | 0 | 5 | 54 | |
| GSE47630 | CDK5R2 | 8941 | 4 | 5 | 31 | |
| GSE54993 | CDK5R2 | 8941 | 1 | 2 | 67 | |
| GSE54994 | CDK5R2 | 8941 | 7 | 10 | 36 | |
| GSE60625 | CDK5R2 | 8941 | 0 | 3 | 8 | |
| GSE74703 | CDK5R2 | 8941 | 1 | 5 | 30 | |
| GSE74704 | CDK5R2 | 8941 | 1 | 7 | 12 | |
| TCGA | CDK5R2 | 8941 | 11 | 27 | 58 |
Total number of gains: 28; Total number of losses: 98; Total Number of normals: 362.
Somatic mutations of CDK5R2:
Generating mutation plots.
Highly correlated genes for CDK5R2:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK5R2 | SVOPL | 0.833728 | 3 | 0 | 3 |
| CDK5R2 | OR2T1 | 0.802329 | 3 | 0 | 3 |
| CDK5R2 | OR2T27 | 0.780208 | 3 | 0 | 3 |
| CDK5R2 | DCDC1 | 0.779204 | 3 | 0 | 3 |
| CDK5R2 | MRGPRG | 0.751803 | 3 | 0 | 3 |
| CDK5R2 | PNPLA7 | 0.742707 | 3 | 0 | 3 |
| CDK5R2 | KRTAP10-12 | 0.739593 | 3 | 0 | 3 |
| CDK5R2 | LHB | 0.736116 | 3 | 0 | 3 |
| CDK5R2 | CBX8 | 0.731742 | 4 | 0 | 4 |
| CDK5R2 | P4HA3 | 0.727214 | 3 | 0 | 3 |
| CDK5R2 | OPTC | 0.724272 | 4 | 0 | 4 |
| CDK5R2 | CCNL2 | 0.713735 | 3 | 0 | 3 |
| CDK5R2 | GJD4 | 0.703023 | 5 | 0 | 4 |
| CDK5R2 | CALML6 | 0.698376 | 4 | 0 | 4 |
| CDK5R2 | SLC22A12 | 0.690961 | 4 | 0 | 3 |
| CDK5R2 | GPR182 | 0.689021 | 5 | 0 | 5 |
| CDK5R2 | VHL | 0.6813 | 4 | 0 | 3 |
| CDK5R2 | KCNK9 | 0.678265 | 4 | 0 | 3 |
| CDK5R2 | KRT74 | 0.677169 | 4 | 0 | 3 |
| CDK5R2 | SHROOM4 | 0.674973 | 4 | 0 | 3 |
For details and further investigation, click here
