GPRIN1

 

Full name: G protein regulated inducer of neurite outgrowth 1 Alias Symbol: GRIN1|KIAA1893
Type: protein-coding gene Cytoband: 5q35.2
Entrez ID: 114787 HGNC ID: HGNC:24835 Ensembl Gene: ENSG00000169258 OMIM ID: 611239
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GPRIN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GPRIN1 114787 227975_at 1.1310 0.0229
GSE26886 GPRIN1 114787 227975_at 0.4771 0.0001
GSE45670 GPRIN1 114787 227975_at 0.0995 0.4211
GSE53622 GPRIN1 114787 89586 1.8726 0.0000
GSE53624 GPRIN1 114787 89586 1.7312 0.0000
GSE63941 GPRIN1 114787 227975_at 0.5219 0.1816
GSE77861 GPRIN1 114787 227975_at 0.2183 0.2309
GSE97050 GPRIN1 114787 A_24_P160466 0.9923 0.1166
SRP007169 GPRIN1 114787 RNAseq 5.7375 0.0001
SRP008496 GPRIN1 114787 RNAseq 4.6511 0.0000
SRP064894 GPRIN1 114787 RNAseq 3.2871 0.0000
SRP133303 GPRIN1 114787 RNAseq 3.1127 0.0000
SRP159526 GPRIN1 114787 RNAseq 2.2002 0.0002
SRP193095 GPRIN1 114787 RNAseq 1.5399 0.0000
SRP219564 GPRIN1 114787 RNAseq 2.9322 0.0007
TCGA GPRIN1 114787 RNAseq 0.9960 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by GPRIN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GPRIN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GPRIN1 114787 2 13 15
GSE20123 GPRIN1 114787 2 13 15
GSE43470 GPRIN1 114787 1 11 31
GSE46452 GPRIN1 114787 0 27 32
GSE47630 GPRIN1 114787 0 20 20
GSE54993 GPRIN1 114787 10 2 58
GSE54994 GPRIN1 114787 2 17 34
GSE60625 GPRIN1 114787 1 0 10
GSE74703 GPRIN1 114787 1 7 28
GSE74704 GPRIN1 114787 1 6 13
TCGA GPRIN1 114787 7 35 54

Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.  

 

Somatic mutations of GPRIN1:

 

Generating mutation plots.

 

Highly correlated genes for GPRIN1:

 

Showing top 20/768 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GPRIN1LRWD10.793204303
GPRIN1SALL40.779995606
GPRIN1DNAJB110.777935303
GPRIN1MFSD100.776985404
GPRIN1BOP10.773679303
GPRIN1HOXD100.769146606
GPRIN1RFX80.76381303
GPRIN1TIMM500.751027404
GPRIN1C16orf740.748245505
GPRIN1USB10.743939505
GPRIN1FMNL20.740762404
GPRIN1RHBDL10.735471303
GPRIN1TNIP20.73149404
GPRIN1DMP10.73143404
GPRIN1CHST10.7311404
GPRIN1KIF26B0.728445606
GPRIN1ATAD20.726202404
GPRIN1KLK30.725735303
GPRIN1KRT90.724668303
GPRIN1SERPINH10.723121505

For details and further investigation, click here