| Full name: C-C motif chemokine ligand 16 | Alias Symbol: NCC-4|SCYL4|LEC|HCC-4|LMC|LCC-1|CKb12|Mtn-1 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6360 | HGNC ID: HGNC:10614 | Ensembl Gene: ENSG00000275152 | OMIM ID: 601394 |
| Drug and gene relationship at DGIdb | |||
CCL16 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL16 | 6360 | 207354_at | -0.3911 | 0.1936 | |
| GSE20347 | CCL16 | 6360 | 207354_at | 0.0125 | 0.9186 | |
| GSE23400 | CCL16 | 6360 | 207354_at | -0.0802 | 0.0776 | |
| GSE26886 | CCL16 | 6360 | 207354_at | 0.2194 | 0.1182 | |
| GSE29001 | CCL16 | 6360 | 207354_at | -0.1895 | 0.2730 | |
| GSE38129 | CCL16 | 6360 | 207354_at | -0.1682 | 0.1436 | |
| GSE45670 | CCL16 | 6360 | 207354_at | -0.2050 | 0.0579 | |
| GSE53622 | CCL16 | 6360 | 36436 | -0.7211 | 0.0000 | |
| GSE53624 | CCL16 | 6360 | 36436 | -0.7268 | 0.0000 | |
| GSE63941 | CCL16 | 6360 | 207354_at | 0.0925 | 0.6326 | |
| GSE77861 | CCL16 | 6360 | 207354_at | -0.0225 | 0.8866 | |
| GSE97050 | CCL16 | 6360 | A_33_P3292478 | -0.3639 | 0.3290 | |
| SRP133303 | CCL16 | 6360 | RNAseq | -0.0906 | 0.6266 | |
| TCGA | CCL16 | 6360 | RNAseq | -1.9077 | 0.0821 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCL16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL16 | 6360 | 5 | 1 | 24 | |
| GSE20123 | CCL16 | 6360 | 5 | 1 | 24 | |
| GSE43470 | CCL16 | 6360 | 1 | 2 | 40 | |
| GSE46452 | CCL16 | 6360 | 34 | 0 | 25 | |
| GSE47630 | CCL16 | 6360 | 7 | 1 | 32 | |
| GSE54993 | CCL16 | 6360 | 3 | 3 | 64 | |
| GSE54994 | CCL16 | 6360 | 8 | 6 | 39 | |
| GSE60625 | CCL16 | 6360 | 4 | 0 | 7 | |
| GSE74703 | CCL16 | 6360 | 1 | 1 | 34 | |
| GSE74704 | CCL16 | 6360 | 3 | 1 | 16 | |
| TCGA | CCL16 | 6360 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of CCL16:
Generating mutation plots.
Highly correlated genes for CCL16:
Showing top 20/845 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL16 | IL1RAPL2 | 0.752686 | 4 | 0 | 4 |
| CCL16 | C8orf58 | 0.741057 | 3 | 0 | 3 |
| CCL16 | ASB16 | 0.735863 | 3 | 0 | 3 |
| CCL16 | C16orf71 | 0.73158 | 4 | 0 | 4 |
| CCL16 | BCAN | 0.727269 | 4 | 0 | 3 |
| CCL16 | KHDRBS2 | 0.725416 | 4 | 0 | 4 |
| CCL16 | ARHGEF7-IT1 | 0.723585 | 3 | 0 | 3 |
| CCL16 | CA7 | 0.717713 | 4 | 0 | 3 |
| CCL16 | C1orf105 | 0.714394 | 4 | 0 | 4 |
| CCL16 | TMEM212 | 0.713728 | 3 | 0 | 3 |
| CCL16 | CER1 | 0.711262 | 6 | 0 | 6 |
| CCL16 | CAMK2B | 0.7077 | 4 | 0 | 3 |
| CCL16 | SLC35D2 | 0.704581 | 3 | 0 | 3 |
| CCL16 | CHRM5 | 0.703902 | 5 | 0 | 5 |
| CCL16 | GP2 | 0.703716 | 6 | 0 | 5 |
| CCL16 | G6PC2 | 0.700978 | 4 | 0 | 3 |
| CCL16 | CETN1 | 0.699368 | 5 | 0 | 4 |
| CCL16 | SLC8A1 | 0.692999 | 4 | 0 | 4 |
| CCL16 | HSF4 | 0.690094 | 4 | 0 | 4 |
| CCL16 | GJB4 | 0.689289 | 5 | 0 | 5 |
For details and further investigation, click here
