| Full name: heat shock transcription factor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 3299 | HGNC ID: HGNC:5227 | Ensembl Gene: ENSG00000102878 | OMIM ID: 602438 |
| Drug and gene relationship at DGIdb | |||
Expression of HSF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSF4 | 3299 | 210977_s_at | -0.0941 | 0.7944 | |
| GSE20347 | HSF4 | 3299 | 210977_s_at | 0.2316 | 0.0057 | |
| GSE23400 | HSF4 | 3299 | 210977_s_at | 0.0468 | 0.3471 | |
| GSE26886 | HSF4 | 3299 | 210977_s_at | 0.0251 | 0.8762 | |
| GSE29001 | HSF4 | 3299 | 210977_s_at | -0.1235 | 0.5511 | |
| GSE38129 | HSF4 | 3299 | 210977_s_at | 0.0683 | 0.5686 | |
| GSE45670 | HSF4 | 3299 | 210977_s_at | -0.1005 | 0.3753 | |
| GSE53622 | HSF4 | 3299 | 116599 | 0.2798 | 0.0020 | |
| GSE53624 | HSF4 | 3299 | 116599 | 0.2534 | 0.0021 | |
| GSE63941 | HSF4 | 3299 | 210977_s_at | 0.3424 | 0.0896 | |
| GSE77861 | HSF4 | 3299 | 210977_s_at | 0.0734 | 0.6786 | |
| GSE97050 | HSF4 | 3299 | A_23_P3592 | -0.2725 | 0.4174 | |
| SRP007169 | HSF4 | 3299 | RNAseq | 0.5391 | 0.4004 | |
| SRP064894 | HSF4 | 3299 | RNAseq | 0.0509 | 0.8435 | |
| SRP133303 | HSF4 | 3299 | RNAseq | -0.2252 | 0.2733 | |
| SRP159526 | HSF4 | 3299 | RNAseq | 0.5047 | 0.2036 | |
| SRP193095 | HSF4 | 3299 | RNAseq | 0.9971 | 0.0000 | |
| SRP219564 | HSF4 | 3299 | RNAseq | -0.2056 | 0.6774 | |
| TCGA | HSF4 | 3299 | RNAseq | -0.1023 | 0.4227 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSF4 | 3299 | 8 | 2 | 20 | |
| GSE20123 | HSF4 | 3299 | 8 | 2 | 20 | |
| GSE43470 | HSF4 | 3299 | 1 | 9 | 33 | |
| GSE46452 | HSF4 | 3299 | 38 | 1 | 20 | |
| GSE47630 | HSF4 | 3299 | 10 | 8 | 22 | |
| GSE54993 | HSF4 | 3299 | 2 | 4 | 64 | |
| GSE54994 | HSF4 | 3299 | 8 | 10 | 35 | |
| GSE60625 | HSF4 | 3299 | 4 | 0 | 7 | |
| GSE74703 | HSF4 | 3299 | 1 | 6 | 29 | |
| GSE74704 | HSF4 | 3299 | 5 | 1 | 14 | |
| TCGA | HSF4 | 3299 | 29 | 12 | 55 |
Total number of gains: 114; Total number of losses: 55; Total Number of normals: 319.
Somatic mutations of HSF4:
Generating mutation plots.
Highly correlated genes for HSF4:
Showing top 20/547 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSF4 | ZFHX2 | 0.765023 | 3 | 0 | 3 |
| HSF4 | INSC | 0.754472 | 3 | 0 | 3 |
| HSF4 | UPK3A | 0.736726 | 3 | 0 | 3 |
| HSF4 | RAB3IL1 | 0.731904 | 5 | 0 | 5 |
| HSF4 | MAPK8IP2 | 0.72177 | 4 | 0 | 4 |
| HSF4 | ARVCF | 0.720274 | 6 | 0 | 5 |
| HSF4 | CPNE6 | 0.718571 | 5 | 0 | 5 |
| HSF4 | PCBP4 | 0.716707 | 4 | 0 | 3 |
| HSF4 | RPH3A | 0.709703 | 3 | 0 | 3 |
| HSF4 | ELAVL3 | 0.707627 | 4 | 0 | 4 |
| HSF4 | ACTL6B | 0.70611 | 3 | 0 | 3 |
| HSF4 | TSKS | 0.703506 | 4 | 0 | 4 |
| HSF4 | DNAJA4 | 0.70221 | 5 | 0 | 5 |
| HSF4 | CYP3A4 | 0.699555 | 3 | 0 | 3 |
| HSF4 | LTB4R2 | 0.694946 | 4 | 0 | 4 |
| HSF4 | NPPA | 0.693288 | 7 | 0 | 5 |
| HSF4 | ASTN1 | 0.693048 | 3 | 0 | 3 |
| HSF4 | CCL16 | 0.690094 | 4 | 0 | 4 |
| HSF4 | HRC | 0.6897 | 4 | 0 | 3 |
| HSF4 | LY6G5C | 0.689416 | 4 | 0 | 3 |
For details and further investigation, click here
