| Full name: cholinergic receptor muscarinic 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q14 | ||
| Entrez ID: 1133 | HGNC ID: HGNC:1954 | Ensembl Gene: ENSG00000184984 | OMIM ID: 118496 |
| Drug and gene relationship at DGIdb | |||
CHRM5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04725 | Cholinergic synapse | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of CHRM5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRM5 | 1133 | 221347_at | 0.0383 | 0.9089 | |
| GSE20347 | CHRM5 | 1133 | 221347_at | 0.1311 | 0.2389 | |
| GSE23400 | CHRM5 | 1133 | 221347_at | -0.1368 | 0.0112 | |
| GSE26886 | CHRM5 | 1133 | 221347_at | 0.1162 | 0.5202 | |
| GSE29001 | CHRM5 | 1133 | 221347_at | -0.1298 | 0.4075 | |
| GSE38129 | CHRM5 | 1133 | 221347_at | -0.1056 | 0.3679 | |
| GSE45670 | CHRM5 | 1133 | 221347_at | 0.0724 | 0.4051 | |
| GSE63941 | CHRM5 | 1133 | 221347_at | 0.1498 | 0.3655 | |
| GSE77861 | CHRM5 | 1133 | 221347_at | -0.0843 | 0.6029 | |
| SRP133303 | CHRM5 | 1133 | RNAseq | -0.1139 | 0.3860 | |
| SRP159526 | CHRM5 | 1133 | RNAseq | 0.0850 | 0.8513 | |
| SRP193095 | CHRM5 | 1133 | RNAseq | -0.2475 | 0.0927 | |
| TCGA | CHRM5 | 1133 | RNAseq | 0.7731 | 0.1005 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRM5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CHRM5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRM5 | 1133 | 3 | 6 | 21 | |
| GSE20123 | CHRM5 | 1133 | 3 | 6 | 21 | |
| GSE43470 | CHRM5 | 1133 | 4 | 4 | 35 | |
| GSE46452 | CHRM5 | 1133 | 3 | 7 | 49 | |
| GSE47630 | CHRM5 | 1133 | 8 | 11 | 21 | |
| GSE54993 | CHRM5 | 1133 | 4 | 6 | 60 | |
| GSE54994 | CHRM5 | 1133 | 5 | 8 | 40 | |
| GSE60625 | CHRM5 | 1133 | 4 | 0 | 7 | |
| GSE74703 | CHRM5 | 1133 | 4 | 3 | 29 | |
| GSE74704 | CHRM5 | 1133 | 2 | 5 | 13 | |
| TCGA | CHRM5 | 1133 | 13 | 17 | 66 |
Total number of gains: 53; Total number of losses: 73; Total Number of normals: 362.
Somatic mutations of CHRM5:
Generating mutation plots.
Highly correlated genes for CHRM5:
Showing top 20/1059 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRM5 | NEU3 | 0.735179 | 4 | 0 | 4 |
| CHRM5 | NTNG1 | 0.733796 | 4 | 0 | 4 |
| CHRM5 | NXPE4 | 0.72829 | 5 | 0 | 5 |
| CHRM5 | SLC7A9 | 0.725657 | 5 | 0 | 5 |
| CHRM5 | CRP | 0.712805 | 4 | 0 | 4 |
| CHRM5 | CDC25C | 0.706976 | 3 | 0 | 3 |
| CHRM5 | CCL16 | 0.703902 | 5 | 0 | 5 |
| CHRM5 | PRL | 0.702831 | 5 | 0 | 5 |
| CHRM5 | DNAJA4 | 0.700846 | 4 | 0 | 4 |
| CHRM5 | SIGLEC6 | 0.691199 | 6 | 0 | 6 |
| CHRM5 | PRR34 | 0.689414 | 6 | 0 | 6 |
| CHRM5 | LINC00052 | 0.685034 | 3 | 0 | 3 |
| CHRM5 | MYL1 | 0.684557 | 5 | 0 | 4 |
| CHRM5 | FSCN3 | 0.684086 | 7 | 0 | 7 |
| CHRM5 | CTRB2 | 0.681031 | 5 | 0 | 5 |
| CHRM5 | AKAP6 | 0.680414 | 5 | 0 | 5 |
| CHRM5 | LINC00216 | 0.678509 | 6 | 0 | 6 |
| CHRM5 | CA7 | 0.675111 | 6 | 0 | 5 |
| CHRM5 | KIR2DS5 | 0.674412 | 6 | 0 | 6 |
| CHRM5 | KCNV1 | 0.671847 | 4 | 0 | 4 |
For details and further investigation, click here
