| Full name: solute carrier family 8 member A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p22.1 | ||
| Entrez ID: 6546 | HGNC ID: HGNC:11068 | Ensembl Gene: ENSG00000183023 | OMIM ID: 182305 |
| Drug and gene relationship at DGIdb | |||
SLC8A1 involved pathways:
Expression of SLC8A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC8A1 | 6546 | 235518_at | -1.3490 | 0.2692 | |
| GSE20347 | SLC8A1 | 6546 | 211805_s_at | 0.1917 | 0.0301 | |
| GSE23400 | SLC8A1 | 6546 | 211805_s_at | 0.0529 | 0.0551 | |
| GSE26886 | SLC8A1 | 6546 | 211805_s_at | -0.0413 | 0.6816 | |
| GSE29001 | SLC8A1 | 6546 | 211805_s_at | 0.1054 | 0.3904 | |
| GSE38129 | SLC8A1 | 6546 | 211805_s_at | 0.0894 | 0.2794 | |
| GSE45670 | SLC8A1 | 6546 | 235518_at | -1.8892 | 0.0000 | |
| GSE53622 | SLC8A1 | 6546 | 58415 | -1.3440 | 0.0000 | |
| GSE53624 | SLC8A1 | 6546 | 93826 | -0.4754 | 0.0000 | |
| GSE63941 | SLC8A1 | 6546 | 211805_s_at | -0.1359 | 0.4870 | |
| GSE77861 | SLC8A1 | 6546 | 211805_s_at | -0.1148 | 0.3377 | |
| GSE97050 | SLC8A1 | 6546 | A_32_P147078 | -0.8501 | 0.1534 | |
| SRP007169 | SLC8A1 | 6546 | RNAseq | 0.7654 | 0.1965 | |
| SRP008496 | SLC8A1 | 6546 | RNAseq | 0.5734 | 0.0817 | |
| SRP064894 | SLC8A1 | 6546 | RNAseq | -0.4596 | 0.2271 | |
| SRP133303 | SLC8A1 | 6546 | RNAseq | -0.9289 | 0.0000 | |
| SRP159526 | SLC8A1 | 6546 | RNAseq | -0.4031 | 0.3563 | |
| SRP193095 | SLC8A1 | 6546 | RNAseq | -0.3493 | 0.0582 | |
| SRP219564 | SLC8A1 | 6546 | RNAseq | -0.1945 | 0.8284 | |
| TCGA | SLC8A1 | 6546 | RNAseq | -0.4773 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SLC8A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC8A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC8A1 | 6546 | 11 | 1 | 18 | |
| GSE20123 | SLC8A1 | 6546 | 9 | 1 | 20 | |
| GSE43470 | SLC8A1 | 6546 | 3 | 0 | 40 | |
| GSE46452 | SLC8A1 | 6546 | 1 | 4 | 54 | |
| GSE47630 | SLC8A1 | 6546 | 7 | 0 | 33 | |
| GSE54993 | SLC8A1 | 6546 | 0 | 5 | 65 | |
| GSE54994 | SLC8A1 | 6546 | 10 | 0 | 43 | |
| GSE60625 | SLC8A1 | 6546 | 0 | 3 | 8 | |
| GSE74703 | SLC8A1 | 6546 | 3 | 0 | 33 | |
| GSE74704 | SLC8A1 | 6546 | 9 | 1 | 10 | |
| TCGA | SLC8A1 | 6546 | 35 | 2 | 59 |
Total number of gains: 88; Total number of losses: 17; Total Number of normals: 383.
Somatic mutations of SLC8A1:
Generating mutation plots.
Highly correlated genes for SLC8A1:
Showing top 20/517 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC8A1 | DACT3 | 0.827341 | 5 | 0 | 5 |
| SLC8A1 | SLMAP | 0.827038 | 3 | 0 | 3 |
| SLC8A1 | FAM13B | 0.825772 | 3 | 0 | 3 |
| SLC8A1 | GPRASP1 | 0.808799 | 3 | 0 | 3 |
| SLC8A1 | MITF | 0.793721 | 4 | 0 | 4 |
| SLC8A1 | EFHD1 | 0.787982 | 3 | 0 | 3 |
| SLC8A1 | ZBTB16 | 0.768165 | 3 | 0 | 3 |
| SLC8A1 | ISCU | 0.767818 | 4 | 0 | 4 |
| SLC8A1 | LINC01279 | 0.763164 | 3 | 0 | 3 |
| SLC8A1 | FILIP1 | 0.760885 | 4 | 0 | 4 |
| SLC8A1 | PDE1A | 0.75795 | 4 | 0 | 4 |
| SLC8A1 | PARD3B | 0.757906 | 3 | 0 | 3 |
| SLC8A1 | MYLK | 0.754681 | 4 | 0 | 3 |
| SLC8A1 | RNF150 | 0.752428 | 4 | 0 | 3 |
| SLC8A1 | SLIT2 | 0.752077 | 4 | 0 | 4 |
| SLC8A1 | NDNF | 0.747721 | 5 | 0 | 5 |
| SLC8A1 | KCNT2 | 0.746319 | 4 | 0 | 4 |
| SLC8A1 | CASQ2 | 0.743431 | 4 | 0 | 3 |
| SLC8A1 | MFAP4 | 0.739801 | 4 | 0 | 4 |
| SLC8A1 | INMT | 0.739494 | 4 | 0 | 4 |
For details and further investigation, click here
