| Full name: gap junction protein beta 4 | Alias Symbol: CX30.3 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 127534 | HGNC ID: HGNC:4286 | Ensembl Gene: ENSG00000189433 | OMIM ID: 605425 |
| Drug and gene relationship at DGIdb | |||
Expression of GJB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJB4 | 127534 | 216579_at | 0.0676 | 0.8393 | |
| GSE20347 | GJB4 | 127534 | 216579_at | -0.0983 | 0.4458 | |
| GSE23400 | GJB4 | 127534 | 216579_at | -0.2036 | 0.0000 | |
| GSE26886 | GJB4 | 127534 | 216579_at | -0.0258 | 0.8687 | |
| GSE29001 | GJB4 | 127534 | 216579_at | -0.3925 | 0.0747 | |
| GSE38129 | GJB4 | 127534 | 216579_at | -0.3129 | 0.0163 | |
| GSE45670 | GJB4 | 127534 | 216579_at | -0.0586 | 0.6211 | |
| GSE53622 | GJB4 | 127534 | 152373 | -0.3582 | 0.0023 | |
| GSE53624 | GJB4 | 127534 | 152373 | -0.2816 | 0.0051 | |
| GSE63941 | GJB4 | 127534 | 216579_at | 0.1365 | 0.4960 | |
| GSE77861 | GJB4 | 127534 | 216579_at | -0.1090 | 0.5233 | |
| GSE97050 | GJB4 | 127534 | A_33_P3388397 | -0.2655 | 0.5049 | |
| SRP007169 | GJB4 | 127534 | RNAseq | 2.1111 | 0.0051 | |
| SRP064894 | GJB4 | 127534 | RNAseq | 1.1613 | 0.0302 | |
| SRP133303 | GJB4 | 127534 | RNAseq | 1.9463 | 0.0000 | |
| SRP159526 | GJB4 | 127534 | RNAseq | 0.9135 | 0.1776 | |
| SRP219564 | GJB4 | 127534 | RNAseq | 0.4161 | 0.6879 | |
| TCGA | GJB4 | 127534 | RNAseq | 1.7670 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by GJB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJB4 | 127534 | 2 | 5 | 23 | |
| GSE20123 | GJB4 | 127534 | 2 | 4 | 24 | |
| GSE43470 | GJB4 | 127534 | 6 | 2 | 35 | |
| GSE46452 | GJB4 | 127534 | 4 | 1 | 54 | |
| GSE47630 | GJB4 | 127534 | 8 | 3 | 29 | |
| GSE54993 | GJB4 | 127534 | 1 | 1 | 68 | |
| GSE54994 | GJB4 | 127534 | 11 | 2 | 40 | |
| GSE60625 | GJB4 | 127534 | 0 | 0 | 11 | |
| GSE74703 | GJB4 | 127534 | 5 | 1 | 30 | |
| GSE74704 | GJB4 | 127534 | 1 | 0 | 19 | |
| TCGA | GJB4 | 127534 | 13 | 18 | 65 |
Total number of gains: 53; Total number of losses: 37; Total Number of normals: 398.
Somatic mutations of GJB4:
Generating mutation plots.
Highly correlated genes for GJB4:
Showing top 20/1151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJB4 | KRT38 | 0.764447 | 4 | 0 | 4 |
| GJB4 | PSG5 | 0.761882 | 4 | 0 | 4 |
| GJB4 | NXPE4 | 0.724112 | 5 | 0 | 5 |
| GJB4 | IRS4 | 0.711333 | 4 | 0 | 4 |
| GJB4 | MS4A12 | 0.710964 | 5 | 0 | 5 |
| GJB4 | CRISP1 | 0.707107 | 6 | 0 | 5 |
| GJB4 | CGA | 0.703753 | 6 | 0 | 6 |
| GJB4 | SCNN1G | 0.699009 | 5 | 0 | 4 |
| GJB4 | KRT76 | 0.69445 | 5 | 0 | 4 |
| GJB4 | OR1D2 | 0.694446 | 6 | 0 | 6 |
| GJB4 | LGALS12 | 0.694157 | 3 | 0 | 3 |
| GJB4 | TEX15 | 0.694058 | 4 | 0 | 4 |
| GJB4 | OR7C2 | 0.692874 | 4 | 0 | 4 |
| GJB4 | IL1RAPL2 | 0.691808 | 7 | 0 | 6 |
| GJB4 | SCTR | 0.691578 | 7 | 0 | 7 |
| GJB4 | TFAP2E | 0.690819 | 3 | 0 | 3 |
| GJB4 | CCL16 | 0.689289 | 5 | 0 | 5 |
| GJB4 | AMBN | 0.687803 | 9 | 0 | 9 |
| GJB4 | BCAN | 0.687392 | 8 | 0 | 6 |
| GJB4 | NPAP1 | 0.684875 | 5 | 0 | 4 |
For details and further investigation, click here
