| Full name: cyclin T1 | Alias Symbol: CCNT|CYCT1 | ||
| Type: protein-coding gene | Cytoband: 12q13.11-q13.12 | ||
| Entrez ID: 904 | HGNC ID: HGNC:1599 | Ensembl Gene: ENSG00000129315 | OMIM ID: 143055 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CCNT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCNT1 | 904 | 225493_at | 0.3519 | 0.4896 | |
| GSE20347 | CCNT1 | 904 | 206967_at | 0.2326 | 0.1105 | |
| GSE23400 | CCNT1 | 904 | 206967_at | 0.0176 | 0.7490 | |
| GSE26886 | CCNT1 | 904 | 225493_at | 0.3508 | 0.0143 | |
| GSE29001 | CCNT1 | 904 | 206967_at | 0.0457 | 0.8808 | |
| GSE38129 | CCNT1 | 904 | 206967_at | 0.3230 | 0.0061 | |
| GSE45670 | CCNT1 | 904 | 225493_at | 0.2453 | 0.0156 | |
| GSE53622 | CCNT1 | 904 | 71761 | -0.0046 | 0.9412 | |
| GSE53624 | CCNT1 | 904 | 71761 | 0.2803 | 0.0000 | |
| GSE63941 | CCNT1 | 904 | 225493_at | -0.0944 | 0.8043 | |
| GSE77861 | CCNT1 | 904 | 225493_at | 0.5773 | 0.0177 | |
| GSE97050 | CCNT1 | 904 | A_23_P87575 | 0.2948 | 0.1924 | |
| SRP007169 | CCNT1 | 904 | RNAseq | 0.1378 | 0.7213 | |
| SRP008496 | CCNT1 | 904 | RNAseq | 0.1145 | 0.5422 | |
| SRP064894 | CCNT1 | 904 | RNAseq | -0.1224 | 0.5535 | |
| SRP133303 | CCNT1 | 904 | RNAseq | 0.4657 | 0.0055 | |
| SRP159526 | CCNT1 | 904 | RNAseq | 0.1173 | 0.6055 | |
| SRP193095 | CCNT1 | 904 | RNAseq | 0.1034 | 0.2448 | |
| SRP219564 | CCNT1 | 904 | RNAseq | 0.0307 | 0.9037 | |
| TCGA | CCNT1 | 904 | RNAseq | -0.1075 | 0.1716 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCNT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCNT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCNT1 | 904 | 5 | 1 | 24 | |
| GSE20123 | CCNT1 | 904 | 5 | 1 | 24 | |
| GSE43470 | CCNT1 | 904 | 3 | 1 | 39 | |
| GSE46452 | CCNT1 | 904 | 8 | 1 | 50 | |
| GSE47630 | CCNT1 | 904 | 11 | 2 | 27 | |
| GSE54993 | CCNT1 | 904 | 0 | 5 | 65 | |
| GSE54994 | CCNT1 | 904 | 6 | 1 | 46 | |
| GSE60625 | CCNT1 | 904 | 0 | 0 | 11 | |
| GSE74703 | CCNT1 | 904 | 3 | 1 | 32 | |
| GSE74704 | CCNT1 | 904 | 3 | 1 | 16 | |
| TCGA | CCNT1 | 904 | 16 | 12 | 68 |
Total number of gains: 60; Total number of losses: 26; Total Number of normals: 402.
Somatic mutations of CCNT1:
Generating mutation plots.
Highly correlated genes for CCNT1:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCNT1 | ZBTB2 | 0.851427 | 3 | 0 | 3 |
| CCNT1 | SF1 | 0.837907 | 3 | 0 | 3 |
| CCNT1 | GOLPH3 | 0.820133 | 3 | 0 | 3 |
| CCNT1 | ANKIB1 | 0.820011 | 3 | 0 | 3 |
| CCNT1 | INO80E | 0.80069 | 3 | 0 | 3 |
| CCNT1 | PIK3CA | 0.800525 | 3 | 0 | 3 |
| CCNT1 | ZNF791 | 0.788864 | 4 | 0 | 4 |
| CCNT1 | PRR12 | 0.788291 | 3 | 0 | 3 |
| CCNT1 | XAB2 | 0.768198 | 4 | 0 | 4 |
| CCNT1 | SMURF2 | 0.765852 | 3 | 0 | 3 |
| CCNT1 | VPS72 | 0.764112 | 3 | 0 | 3 |
| CCNT1 | WDR25 | 0.763343 | 3 | 0 | 3 |
| CCNT1 | POLA1 | 0.761593 | 3 | 0 | 3 |
| CCNT1 | SLC39A14 | 0.761522 | 3 | 0 | 3 |
| CCNT1 | TFDP2 | 0.76097 | 3 | 0 | 3 |
| CCNT1 | TMSB15B | 0.755197 | 3 | 0 | 3 |
| CCNT1 | KPNA5 | 0.752296 | 3 | 0 | 3 |
| CCNT1 | CLIC4 | 0.750933 | 3 | 0 | 3 |
| CCNT1 | ZNF766 | 0.748233 | 3 | 0 | 3 |
| CCNT1 | FAM102B | 0.746381 | 3 | 0 | 3 |
For details and further investigation, click here
