PIK3CA

 

Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Alias Symbol: PI3K
Type: protein-coding gene Cytoband: 3q26.32
Entrez ID: 5290 HGNC ID: HGNC:8975 Ensembl Gene: ENSG00000121879 OMIM ID: 171834
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 135/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIK3CA involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PIK3CA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIK3CA 5290 204369_at 0.1489 0.7283
GSE20347 PIK3CA 5290 204369_at 0.5354 0.0051
GSE23400 PIK3CA 5290 204369_at 0.6435 0.0000
GSE26886 PIK3CA 5290 204369_at 0.4954 0.2207
GSE29001 PIK3CA 5290 204369_at 0.7311 0.1538
GSE38129 PIK3CA 5290 204369_at 0.6421 0.0000
GSE45670 PIK3CA 5290 204369_at 0.1383 0.5461
GSE53622 PIK3CA 5290 61893 0.5868 0.0000
GSE53624 PIK3CA 5290 61893 0.5532 0.0000
GSE63941 PIK3CA 5290 204369_at 0.3733 0.5925
GSE77861 PIK3CA 5290 204369_at 0.8179 0.0189
GSE97050 PIK3CA 5290 A_23_P92057 0.1813 0.3871
SRP007169 PIK3CA 5290 RNAseq 1.9627 0.0026
SRP008496 PIK3CA 5290 RNAseq 1.6044 0.0001
SRP064894 PIK3CA 5290 RNAseq 0.4752 0.0130
SRP133303 PIK3CA 5290 RNAseq 0.8617 0.0000
SRP159526 PIK3CA 5290 RNAseq 0.9277 0.0080
SRP193095 PIK3CA 5290 RNAseq 0.6278 0.0000
SRP219564 PIK3CA 5290 RNAseq 0.0193 0.9529
TCGA PIK3CA 5290 RNAseq 0.1442 0.0158

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PIK3CA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIK3CA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIK3CA 5290 25 0 5
GSE20123 PIK3CA 5290 25 0 5
GSE43470 PIK3CA 5290 24 0 19
GSE46452 PIK3CA 5290 19 1 39
GSE47630 PIK3CA 5290 27 2 11
GSE54993 PIK3CA 5290 1 18 51
GSE54994 PIK3CA 5290 41 0 12
GSE60625 PIK3CA 5290 0 6 5
GSE74703 PIK3CA 5290 20 0 16
GSE74704 PIK3CA 5290 16 0 4
TCGA PIK3CA 5290 78 0 18

Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.  

 

Somatic mutations of PIK3CA:

 

Generating mutation plots.

 

Highly correlated genes for PIK3CA:

 

Showing top 20/1253 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIK3CACCNT10.800525303
PIK3CASMCR80.74885303
PIK3CAUHMK10.737559404
PIK3CAFXR10.73462510010
PIK3CAREV10.732879303
PIK3CAZNF320.730821505
PIK3CAMETAP1D0.723082403
PIK3CAPTPMT10.714727303
PIK3CARGMB0.711549303
PIK3CASNX300.711135303
PIK3CACBFA2T20.710999403
PIK3CAUCN0.710268303
PIK3CAPCGF60.70781504
PIK3CAALMS10.700313303
PIK3CAUSP200.699863303
PIK3CALRRC340.697827303
PIK3CACDKL30.697441303
PIK3CAZBED10.695778303
PIK3CAUSP30.695546303
PIK3CAZNF3220.690679707

For details and further investigation, click here