| Full name: vacuolar protein sorting 72 homolog | Alias Symbol: YL-1|YL1|Swc2 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6944 | HGNC ID: HGNC:11644 | Ensembl Gene: ENSG00000163159 | OMIM ID: 600607 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS72:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS72 | 6944 | 202261_at | 0.4120 | 0.2080 | |
| GSE20347 | VPS72 | 6944 | 202261_at | 0.4927 | 0.0001 | |
| GSE23400 | VPS72 | 6944 | 202261_at | 0.3969 | 0.0000 | |
| GSE26886 | VPS72 | 6944 | 202261_at | 0.4034 | 0.0240 | |
| GSE29001 | VPS72 | 6944 | 202261_at | 0.5983 | 0.0081 | |
| GSE38129 | VPS72 | 6944 | 202261_at | 0.4246 | 0.0006 | |
| GSE45670 | VPS72 | 6944 | 202261_at | 0.3987 | 0.0069 | |
| GSE53622 | VPS72 | 6944 | 123350 | 0.4770 | 0.0000 | |
| GSE53624 | VPS72 | 6944 | 123350 | 0.6291 | 0.0000 | |
| GSE63941 | VPS72 | 6944 | 202261_at | 1.2628 | 0.0005 | |
| GSE77861 | VPS72 | 6944 | 202261_at | 0.9099 | 0.0013 | |
| GSE97050 | VPS72 | 6944 | A_23_P115215 | -0.1121 | 0.7312 | |
| SRP007169 | VPS72 | 6944 | RNAseq | -0.0212 | 0.9584 | |
| SRP008496 | VPS72 | 6944 | RNAseq | 0.5439 | 0.1338 | |
| SRP064894 | VPS72 | 6944 | RNAseq | 0.3476 | 0.1263 | |
| SRP133303 | VPS72 | 6944 | RNAseq | 0.3967 | 0.0019 | |
| SRP159526 | VPS72 | 6944 | RNAseq | 0.7838 | 0.0048 | |
| SRP193095 | VPS72 | 6944 | RNAseq | 0.3417 | 0.0044 | |
| SRP219564 | VPS72 | 6944 | RNAseq | 0.1652 | 0.6378 | |
| TCGA | VPS72 | 6944 | RNAseq | 0.1522 | 0.0036 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by VPS72 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS72:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS72 | 6944 | 14 | 0 | 16 | |
| GSE20123 | VPS72 | 6944 | 14 | 0 | 16 | |
| GSE43470 | VPS72 | 6944 | 6 | 1 | 36 | |
| GSE46452 | VPS72 | 6944 | 2 | 1 | 56 | |
| GSE47630 | VPS72 | 6944 | 14 | 0 | 26 | |
| GSE54993 | VPS72 | 6944 | 0 | 4 | 66 | |
| GSE54994 | VPS72 | 6944 | 15 | 0 | 38 | |
| GSE60625 | VPS72 | 6944 | 0 | 0 | 11 | |
| GSE74703 | VPS72 | 6944 | 6 | 1 | 29 | |
| GSE74704 | VPS72 | 6944 | 7 | 0 | 13 | |
| TCGA | VPS72 | 6944 | 37 | 2 | 57 |
Total number of gains: 115; Total number of losses: 9; Total Number of normals: 364.
Somatic mutations of VPS72:
Generating mutation plots.
Highly correlated genes for VPS72:
Showing top 20/1660 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS72 | SCNM1 | 0.797918 | 4 | 0 | 4 |
| VPS72 | SLC39A3 | 0.778201 | 4 | 0 | 4 |
| VPS72 | CCNT1 | 0.764112 | 3 | 0 | 3 |
| VPS72 | CERS2 | 0.76339 | 9 | 0 | 9 |
| VPS72 | INPP5K | 0.761373 | 3 | 0 | 3 |
| VPS72 | MB21D2 | 0.758958 | 4 | 0 | 4 |
| VPS72 | ZNF567 | 0.757985 | 3 | 0 | 3 |
| VPS72 | RAB34 | 0.75309 | 3 | 0 | 3 |
| VPS72 | PSMD4 | 0.746774 | 10 | 0 | 9 |
| VPS72 | TEAD2 | 0.739235 | 6 | 0 | 6 |
| VPS72 | TMEM17 | 0.730934 | 3 | 0 | 3 |
| VPS72 | NF1 | 0.728485 | 3 | 0 | 3 |
| VPS72 | ZNF518B | 0.722341 | 5 | 0 | 5 |
| VPS72 | KRTCAP2 | 0.721603 | 5 | 0 | 4 |
| VPS72 | TAF3 | 0.720887 | 3 | 0 | 3 |
| VPS72 | KLHL36 | 0.720619 | 3 | 0 | 3 |
| VPS72 | FADS1 | 0.720053 | 3 | 0 | 3 |
| VPS72 | ZNF683 | 0.719053 | 3 | 0 | 3 |
| VPS72 | RPS6KC1 | 0.717037 | 10 | 0 | 9 |
| VPS72 | KBTBD7 | 0.716347 | 3 | 0 | 3 |
For details and further investigation, click here
