| Full name: karyopherin subunit alpha 5 | Alias Symbol: SRP6|IPOA6 | ||
| Type: protein-coding gene | Cytoband: 6q22.1 | ||
| Entrez ID: 3841 | HGNC ID: HGNC:6398 | Ensembl Gene: ENSG00000196911 | OMIM ID: 604545 |
| Drug and gene relationship at DGIdb | |||
Expression of KPNA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA5 | 3841 | 227934_at | -0.3051 | 0.6645 | |
| GSE20347 | KPNA5 | 3841 | 206241_at | 0.0985 | 0.1679 | |
| GSE23400 | KPNA5 | 3841 | 206241_at | -0.0013 | 0.9496 | |
| GSE26886 | KPNA5 | 3841 | 227934_at | 0.2304 | 0.5602 | |
| GSE29001 | KPNA5 | 3841 | 206241_at | 0.0812 | 0.3930 | |
| GSE38129 | KPNA5 | 3841 | 206241_at | 0.0015 | 0.9854 | |
| GSE45670 | KPNA5 | 3841 | 227934_at | -0.4535 | 0.0343 | |
| GSE53622 | KPNA5 | 3841 | 9143 | -0.1319 | 0.3100 | |
| GSE53624 | KPNA5 | 3841 | 20613 | -0.4006 | 0.0092 | |
| GSE63941 | KPNA5 | 3841 | 227934_at | -0.1873 | 0.8163 | |
| GSE77861 | KPNA5 | 3841 | 227934_at | 0.1099 | 0.4398 | |
| GSE97050 | KPNA5 | 3841 | A_23_P156443 | -0.0931 | 0.7531 | |
| SRP007169 | KPNA5 | 3841 | RNAseq | 0.4215 | 0.1989 | |
| SRP008496 | KPNA5 | 3841 | RNAseq | 0.8278 | 0.0002 | |
| SRP064894 | KPNA5 | 3841 | RNAseq | -0.7426 | 0.0000 | |
| SRP133303 | KPNA5 | 3841 | RNAseq | -0.3468 | 0.0155 | |
| SRP159526 | KPNA5 | 3841 | RNAseq | -0.5984 | 0.0140 | |
| SRP193095 | KPNA5 | 3841 | RNAseq | 0.1094 | 0.4128 | |
| SRP219564 | KPNA5 | 3841 | RNAseq | -1.2548 | 0.0063 | |
| TCGA | KPNA5 | 3841 | RNAseq | -0.2382 | 0.0958 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KPNA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA5 | 3841 | 1 | 4 | 25 | |
| GSE20123 | KPNA5 | 3841 | 1 | 3 | 26 | |
| GSE43470 | KPNA5 | 3841 | 3 | 1 | 39 | |
| GSE46452 | KPNA5 | 3841 | 2 | 11 | 46 | |
| GSE47630 | KPNA5 | 3841 | 9 | 4 | 27 | |
| GSE54993 | KPNA5 | 3841 | 3 | 2 | 65 | |
| GSE54994 | KPNA5 | 3841 | 8 | 8 | 37 | |
| GSE60625 | KPNA5 | 3841 | 0 | 1 | 10 | |
| GSE74703 | KPNA5 | 3841 | 2 | 1 | 33 | |
| GSE74704 | KPNA5 | 3841 | 0 | 1 | 19 | |
| TCGA | KPNA5 | 3841 | 7 | 22 | 67 |
Total number of gains: 36; Total number of losses: 58; Total Number of normals: 394.
Somatic mutations of KPNA5:
Generating mutation plots.
Highly correlated genes for KPNA5:
Showing top 20/360 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA5 | PDHX | 0.792327 | 3 | 0 | 3 |
| KPNA5 | IGFBP5 | 0.765221 | 3 | 0 | 3 |
| KPNA5 | CCNT1 | 0.752296 | 3 | 0 | 3 |
| KPNA5 | CHURC1 | 0.749524 | 3 | 0 | 3 |
| KPNA5 | TMEM18 | 0.745804 | 3 | 0 | 3 |
| KPNA5 | DIS3L | 0.740479 | 3 | 0 | 3 |
| KPNA5 | SORL1 | 0.730705 | 3 | 0 | 3 |
| KPNA5 | TMEM38B | 0.727898 | 3 | 0 | 3 |
| KPNA5 | RPL34 | 0.717971 | 3 | 0 | 3 |
| KPNA5 | CASC4 | 0.71554 | 3 | 0 | 3 |
| KPNA5 | MYC | 0.714636 | 3 | 0 | 3 |
| KPNA5 | FAM8A1 | 0.713209 | 3 | 0 | 3 |
| KPNA5 | TSNAX | 0.708061 | 3 | 0 | 3 |
| KPNA5 | MED17 | 0.706143 | 3 | 0 | 3 |
| KPNA5 | TADA1 | 0.699169 | 3 | 0 | 3 |
| KPNA5 | CDC40 | 0.697771 | 4 | 0 | 3 |
| KPNA5 | FBXL3 | 0.693025 | 3 | 0 | 3 |
| KPNA5 | DDX59 | 0.691887 | 4 | 0 | 3 |
| KPNA5 | KCNE3 | 0.689016 | 3 | 0 | 3 |
| KPNA5 | KCNT2 | 0.68839 | 3 | 0 | 3 |
For details and further investigation, click here
