| Full name: chloride intracellular channel 4 | Alias Symbol: DKFZP566G223|CLIC4L|P64H1|H1|huH1|p64H1 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 25932 | HGNC ID: HGNC:13518 | Ensembl Gene: ENSG00000169504 | OMIM ID: 606536 |
| Drug and gene relationship at DGIdb | |||
Expression of CLIC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLIC4 | 25932 | 201560_at | -0.1410 | 0.8680 | |
| GSE20347 | CLIC4 | 25932 | 201560_at | 1.1768 | 0.0000 | |
| GSE23400 | CLIC4 | 25932 | 201560_at | 0.5443 | 0.0008 | |
| GSE26886 | CLIC4 | 25932 | 201560_at | 1.5642 | 0.0000 | |
| GSE29001 | CLIC4 | 25932 | 201560_at | 1.2737 | 0.0001 | |
| GSE38129 | CLIC4 | 25932 | 201560_at | 0.6148 | 0.0282 | |
| GSE45670 | CLIC4 | 25932 | 201560_at | -0.3283 | 0.2711 | |
| GSE53622 | CLIC4 | 25932 | 109761 | 0.6302 | 0.0001 | |
| GSE53624 | CLIC4 | 25932 | 109761 | 0.7469 | 0.0000 | |
| GSE63941 | CLIC4 | 25932 | 201560_at | -1.5778 | 0.0070 | |
| GSE77861 | CLIC4 | 25932 | 201560_at | 1.9242 | 0.0024 | |
| GSE97050 | CLIC4 | 25932 | A_23_P259189 | 0.1247 | 0.6941 | |
| SRP007169 | CLIC4 | 25932 | RNAseq | 2.0809 | 0.0000 | |
| SRP008496 | CLIC4 | 25932 | RNAseq | 2.2898 | 0.0000 | |
| SRP064894 | CLIC4 | 25932 | RNAseq | 0.5741 | 0.0478 | |
| SRP133303 | CLIC4 | 25932 | RNAseq | 1.1033 | 0.0000 | |
| SRP159526 | CLIC4 | 25932 | RNAseq | 0.1573 | 0.4958 | |
| SRP193095 | CLIC4 | 25932 | RNAseq | 1.2758 | 0.0000 | |
| SRP219564 | CLIC4 | 25932 | RNAseq | -0.4670 | 0.5005 | |
| TCGA | CLIC4 | 25932 | RNAseq | -0.0903 | 0.1150 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by CLIC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLIC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLIC4 | 25932 | 0 | 5 | 25 | |
| GSE20123 | CLIC4 | 25932 | 0 | 4 | 26 | |
| GSE43470 | CLIC4 | 25932 | 2 | 6 | 35 | |
| GSE46452 | CLIC4 | 25932 | 5 | 1 | 53 | |
| GSE47630 | CLIC4 | 25932 | 8 | 3 | 29 | |
| GSE54993 | CLIC4 | 25932 | 2 | 1 | 67 | |
| GSE54994 | CLIC4 | 25932 | 11 | 4 | 38 | |
| GSE60625 | CLIC4 | 25932 | 0 | 0 | 11 | |
| GSE74703 | CLIC4 | 25932 | 1 | 4 | 31 | |
| GSE74704 | CLIC4 | 25932 | 0 | 0 | 20 | |
| TCGA | CLIC4 | 25932 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of CLIC4:
Generating mutation plots.
Highly correlated genes for CLIC4:
Showing top 20/1469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLIC4 | LINC00674 | 0.762443 | 3 | 0 | 3 |
| CLIC4 | COL7A1 | 0.761078 | 3 | 0 | 3 |
| CLIC4 | IGFBP7 | 0.758071 | 12 | 0 | 10 |
| CLIC4 | CALU | 0.757672 | 12 | 0 | 12 |
| CLIC4 | FSTL1 | 0.756795 | 13 | 0 | 13 |
| CLIC4 | CLMP | 0.75656 | 6 | 0 | 5 |
| CLIC4 | RHOQ | 0.754762 | 10 | 0 | 10 |
| CLIC4 | MACF1 | 0.754503 | 13 | 0 | 12 |
| CLIC4 | CCNT1 | 0.750933 | 3 | 0 | 3 |
| CLIC4 | FBN1 | 0.75032 | 11 | 0 | 11 |
| CLIC4 | ANO6 | 0.748898 | 9 | 0 | 9 |
| CLIC4 | LAMC1 | 0.745521 | 13 | 0 | 11 |
| CLIC4 | MRPL9 | 0.743995 | 3 | 0 | 3 |
| CLIC4 | BLOC1S6 | 0.742712 | 3 | 0 | 3 |
| CLIC4 | IGIP | 0.739491 | 3 | 0 | 3 |
| CLIC4 | WDR81 | 0.737543 | 3 | 0 | 3 |
| CLIC4 | MRPL47 | 0.735809 | 3 | 0 | 3 |
| CLIC4 | MCAM | 0.735348 | 10 | 0 | 9 |
| CLIC4 | HIC1 | 0.733857 | 4 | 0 | 4 |
| CLIC4 | CHST15 | 0.730078 | 11 | 0 | 10 |
For details and further investigation, click here
