| Full name: DNA polymerase alpha 1, catalytic subunit | Alias Symbol: p180 | ||
| Type: protein-coding gene | Cytoband: Xp22.11-p21.3 | ||
| Entrez ID: 5422 | HGNC ID: HGNC:9173 | Ensembl Gene: ENSG00000101868 | OMIM ID: 312040 |
| Drug and gene relationship at DGIdb | |||
Expression of POLA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLA1 | 5422 | 204835_at | 0.5080 | 0.4072 | |
| GSE20347 | POLA1 | 5422 | 204835_at | 0.4228 | 0.0126 | |
| GSE23400 | POLA1 | 5422 | 204835_at | 0.2978 | 0.0000 | |
| GSE26886 | POLA1 | 5422 | 204835_at | 0.2094 | 0.3352 | |
| GSE29001 | POLA1 | 5422 | 204835_at | 0.4086 | 0.2066 | |
| GSE38129 | POLA1 | 5422 | 204835_at | 0.4007 | 0.0014 | |
| GSE45670 | POLA1 | 5422 | 204835_at | 0.2919 | 0.2138 | |
| GSE53622 | POLA1 | 5422 | 9649 | 0.1833 | 0.0031 | |
| GSE53624 | POLA1 | 5422 | 9649 | 0.3508 | 0.0000 | |
| GSE63941 | POLA1 | 5422 | 204835_at | 1.5344 | 0.0055 | |
| GSE77861 | POLA1 | 5422 | 204835_at | 0.3550 | 0.0971 | |
| GSE97050 | POLA1 | 5422 | A_32_P1701 | 0.2292 | 0.2536 | |
| SRP007169 | POLA1 | 5422 | RNAseq | 0.6433 | 0.1578 | |
| SRP008496 | POLA1 | 5422 | RNAseq | 0.6997 | 0.0184 | |
| SRP064894 | POLA1 | 5422 | RNAseq | 0.2603 | 0.2571 | |
| SRP133303 | POLA1 | 5422 | RNAseq | 0.6512 | 0.0270 | |
| SRP159526 | POLA1 | 5422 | RNAseq | 0.3477 | 0.1667 | |
| SRP193095 | POLA1 | 5422 | RNAseq | 0.3848 | 0.0004 | |
| SRP219564 | POLA1 | 5422 | RNAseq | 0.8825 | 0.1037 | |
| TCGA | POLA1 | 5422 | RNAseq | 0.2078 | 0.0027 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by POLA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLA1:
No record found for this gene.
Somatic mutations of POLA1:
Generating mutation plots.
Highly correlated genes for POLA1:
Showing top 20/1035 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLA1 | MRPL38 | 0.815925 | 3 | 0 | 3 |
| POLA1 | ANKIB1 | 0.804523 | 3 | 0 | 3 |
| POLA1 | DNASE2 | 0.803934 | 3 | 0 | 3 |
| POLA1 | ALCAM | 0.802966 | 3 | 0 | 3 |
| POLA1 | ELOF1 | 0.775288 | 3 | 0 | 3 |
| POLA1 | LINC01234 | 0.768278 | 3 | 0 | 3 |
| POLA1 | MED26 | 0.762432 | 3 | 0 | 3 |
| POLA1 | CCNT1 | 0.761593 | 3 | 0 | 3 |
| POLA1 | SDHAF2 | 0.760042 | 3 | 0 | 3 |
| POLA1 | PARG | 0.756863 | 4 | 0 | 4 |
| POLA1 | TNK1 | 0.756084 | 3 | 0 | 3 |
| POLA1 | CHCHD5 | 0.752601 | 3 | 0 | 3 |
| POLA1 | NR2C2AP | 0.7526 | 4 | 0 | 4 |
| POLA1 | DNTTIP1 | 0.751424 | 3 | 0 | 3 |
| POLA1 | LRRC8B | 0.751344 | 3 | 0 | 3 |
| POLA1 | PTPRU | 0.743812 | 3 | 0 | 3 |
| POLA1 | TXNDC16 | 0.738836 | 3 | 0 | 3 |
| POLA1 | TIAM2 | 0.736819 | 3 | 0 | 3 |
| POLA1 | KLHL15 | 0.736162 | 3 | 0 | 3 |
| POLA1 | ZNF689 | 0.731821 | 3 | 0 | 3 |
For details and further investigation, click here
