| Full name: cyclin dependent kinase like 2 | Alias Symbol: P56|KKIAMRE | ||
| Type: protein-coding gene | Cytoband: 4q21.1 | ||
| Entrez ID: 8999 | HGNC ID: HGNC:1782 | Ensembl Gene: ENSG00000138769 | OMIM ID: 603442 |
| Drug and gene relationship at DGIdb | |||
Expression of CDKL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKL2 | 8999 | 207073_at | -0.0992 | 0.8087 | |
| GSE20347 | CDKL2 | 8999 | 207073_at | -0.0478 | 0.5935 | |
| GSE23400 | CDKL2 | 8999 | 207073_at | -0.0986 | 0.0684 | |
| GSE26886 | CDKL2 | 8999 | 207073_at | 0.1862 | 0.1126 | |
| GSE29001 | CDKL2 | 8999 | 207073_at | -0.2138 | 0.0854 | |
| GSE38129 | CDKL2 | 8999 | 207073_at | -0.2179 | 0.0295 | |
| GSE45670 | CDKL2 | 8999 | 207073_at | -0.0221 | 0.8169 | |
| GSE53622 | CDKL2 | 8999 | 56317 | -0.7949 | 0.0003 | |
| GSE53624 | CDKL2 | 8999 | 56317 | -1.0913 | 0.0000 | |
| GSE63941 | CDKL2 | 8999 | 207073_at | 0.2900 | 0.1265 | |
| GSE77861 | CDKL2 | 8999 | 207073_at | 0.0099 | 0.9315 | |
| SRP133303 | CDKL2 | 8999 | RNAseq | 0.8562 | 0.1680 | |
| SRP159526 | CDKL2 | 8999 | RNAseq | -1.0457 | 0.0051 | |
| SRP219564 | CDKL2 | 8999 | RNAseq | -0.5678 | 0.4875 | |
| TCGA | CDKL2 | 8999 | RNAseq | -0.4083 | 0.2378 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CDKL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKL2 | 8999 | 2 | 9 | 19 | |
| GSE20123 | CDKL2 | 8999 | 2 | 9 | 19 | |
| GSE43470 | CDKL2 | 8999 | 0 | 13 | 30 | |
| GSE46452 | CDKL2 | 8999 | 2 | 35 | 22 | |
| GSE47630 | CDKL2 | 8999 | 1 | 19 | 20 | |
| GSE54993 | CDKL2 | 8999 | 7 | 0 | 63 | |
| GSE54994 | CDKL2 | 8999 | 1 | 9 | 43 | |
| GSE60625 | CDKL2 | 8999 | 0 | 0 | 11 | |
| GSE74703 | CDKL2 | 8999 | 0 | 11 | 25 | |
| GSE74704 | CDKL2 | 8999 | 2 | 5 | 13 | |
| TCGA | CDKL2 | 8999 | 16 | 30 | 50 |
Total number of gains: 33; Total number of losses: 140; Total Number of normals: 315.
Somatic mutations of CDKL2:
Generating mutation plots.
Highly correlated genes for CDKL2:
Showing top 20/239 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKL2 | ABRA | 0.699569 | 3 | 0 | 3 |
| CDKL2 | CHGA | 0.691403 | 3 | 0 | 3 |
| CDKL2 | CEACAM3 | 0.681592 | 4 | 0 | 4 |
| CDKL2 | RGMB-AS1 | 0.671023 | 3 | 0 | 3 |
| CDKL2 | PRAMEF11 | 0.646982 | 5 | 0 | 4 |
| CDKL2 | RND2 | 0.645138 | 4 | 0 | 4 |
| CDKL2 | BMP3 | 0.642482 | 4 | 0 | 4 |
| CDKL2 | AK8 | 0.641592 | 3 | 0 | 3 |
| CDKL2 | CHCHD10 | 0.63592 | 3 | 0 | 3 |
| CDKL2 | IL37 | 0.631304 | 3 | 0 | 3 |
| CDKL2 | CNTD1 | 0.629066 | 4 | 0 | 4 |
| CDKL2 | SLC10A2 | 0.622767 | 5 | 0 | 4 |
| CDKL2 | FOXA2 | 0.622715 | 4 | 0 | 3 |
| CDKL2 | BTNL8 | 0.620093 | 8 | 0 | 7 |
| CDKL2 | CLDN19 | 0.619456 | 4 | 0 | 4 |
| CDKL2 | SLC12A5 | 0.615647 | 5 | 0 | 4 |
| CDKL2 | CAMK1G | 0.615386 | 4 | 0 | 3 |
| CDKL2 | OR1A1 | 0.613846 | 6 | 0 | 4 |
| CDKL2 | CCL25 | 0.613721 | 5 | 0 | 4 |
| CDKL2 | FRMPD4 | 0.608239 | 5 | 0 | 4 |
For details and further investigation, click here
