| Full name: actin binding Rho activating protein | Alias Symbol: STARS | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 137735 | HGNC ID: HGNC:30655 | Ensembl Gene: ENSG00000174429 | OMIM ID: 609747 |
| Drug and gene relationship at DGIdb | |||
Expression of ABRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABRA | 137735 | 1552731_at | -0.0698 | 0.7775 | |
| GSE26886 | ABRA | 137735 | 1552731_at | 0.2275 | 0.0158 | |
| GSE45670 | ABRA | 137735 | 1552731_at | -0.0273 | 0.7557 | |
| GSE53622 | ABRA | 137735 | 9312 | -0.9786 | 0.0000 | |
| GSE53624 | ABRA | 137735 | 9312 | -1.1818 | 0.0000 | |
| GSE63941 | ABRA | 137735 | 1552731_at | 0.1830 | 0.1952 | |
| GSE77861 | ABRA | 137735 | 1552731_at | -0.0671 | 0.4437 | |
| GSE97050 | ABRA | 137735 | A_33_P3368208 | -0.3202 | 0.4997 | |
| SRP133303 | ABRA | 137735 | RNAseq | -0.4122 | 0.1071 | |
| SRP193095 | ABRA | 137735 | RNAseq | -0.0529 | 0.7340 | |
| TCGA | ABRA | 137735 | RNAseq | -2.0447 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ABRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABRA | 137735 | 16 | 0 | 14 | |
| GSE20123 | ABRA | 137735 | 17 | 0 | 13 | |
| GSE43470 | ABRA | 137735 | 22 | 0 | 21 | |
| GSE46452 | ABRA | 137735 | 25 | 0 | 34 | |
| GSE47630 | ABRA | 137735 | 24 | 0 | 16 | |
| GSE54993 | ABRA | 137735 | 0 | 20 | 50 | |
| GSE54994 | ABRA | 137735 | 37 | 1 | 15 | |
| GSE60625 | ABRA | 137735 | 0 | 4 | 7 | |
| GSE74703 | ABRA | 137735 | 19 | 0 | 17 | |
| GSE74704 | ABRA | 137735 | 11 | 0 | 9 | |
| TCGA | ABRA | 137735 | 60 | 1 | 35 |
Total number of gains: 231; Total number of losses: 26; Total Number of normals: 231.
Somatic mutations of ABRA:
Generating mutation plots.
Highly correlated genes for ABRA:
Showing top 20/283 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABRA | GIPC3 | 0.753762 | 3 | 0 | 3 |
| ABRA | FRRS1L | 0.715032 | 3 | 0 | 3 |
| ABRA | SGCA | 0.714282 | 5 | 0 | 5 |
| ABRA | PCSK2 | 0.713577 | 3 | 0 | 3 |
| ABRA | ITGA7 | 0.709473 | 4 | 0 | 4 |
| ABRA | SLC35F1 | 0.707587 | 3 | 0 | 3 |
| ABRA | JMJD6 | 0.706326 | 3 | 0 | 3 |
| ABRA | NR4A1 | 0.704754 | 3 | 0 | 3 |
| ABRA | CTNNA3 | 0.702233 | 5 | 0 | 5 |
| ABRA | CACNA1C | 0.701458 | 3 | 0 | 3 |
| ABRA | LRRC4C | 0.699666 | 3 | 0 | 3 |
| ABRA | CDKL2 | 0.699569 | 3 | 0 | 3 |
| ABRA | FAM117A | 0.698741 | 3 | 0 | 3 |
| ABRA | SOX17 | 0.694401 | 3 | 0 | 3 |
| ABRA | SLC22A17 | 0.692117 | 3 | 0 | 3 |
| ABRA | NT5M | 0.691948 | 4 | 0 | 4 |
| ABRA | POU6F1 | 0.691092 | 3 | 0 | 3 |
| ABRA | NCAM1 | 0.684633 | 4 | 0 | 4 |
| ABRA | CSPG4 | 0.684201 | 3 | 0 | 3 |
| ABRA | CKMT2 | 0.682572 | 4 | 0 | 4 |
For details and further investigation, click here
