FOXA2

 

Full name: forkhead box A2 Alias Symbol: 
Type: protein-coding gene Cytoband: 20p11.21
Entrez ID: 3170 HGNC ID: HGNC:5022 Ensembl Gene: ENSG00000125798 OMIM ID: 600288
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 7/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

FOXA2 involved pathways:

KEGG pathway Description View
hsa04213Longevity regulating pathway - multiple species
hsa04950Maturity onset diabetes of the young

 

Expression of FOXA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FOXA2 3170 210103_s_at -0.0477 0.8715
GSE20347 FOXA2 3170 214312_at -0.0849 0.1369
GSE23400 FOXA2 3170 210103_s_at -0.1588 0.0006
GSE26886 FOXA2 3170 214312_at 0.1498 0.3773
GSE29001 FOXA2 3170 214312_at 0.0198 0.9000
GSE38129 FOXA2 3170 210103_s_at -0.1621 0.4786
GSE45670 FOXA2 3170 214312_at -0.0859 0.3946
GSE53622 FOXA2 3170 10042 0.2521 0.4545
GSE53624 FOXA2 3170 10042 0.4018 0.1333
GSE63941 FOXA2 3170 210103_s_at 1.1122 0.2964
GSE77861 FOXA2 3170 210103_s_at 0.4301 0.4107
GSE97050 FOXA2 3170 A_24_P365515 0.1953 0.3271
TCGA FOXA2 3170 RNAseq -2.1595 0.0004

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by FOXA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FOXA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FOXA2 3170 13 1 16
GSE20123 FOXA2 3170 13 1 16
GSE43470 FOXA2 3170 10 1 32
GSE46452 FOXA2 3170 27 1 31
GSE47630 FOXA2 3170 17 4 19
GSE54993 FOXA2 3170 0 17 53
GSE54994 FOXA2 3170 26 2 25
GSE60625 FOXA2 3170 0 0 11
GSE74703 FOXA2 3170 8 1 27
GSE74704 FOXA2 3170 7 1 12
TCGA FOXA2 3170 42 11 43

Total number of gains: 163; Total number of losses: 40; Total Number of normals: 285.  

 

Somatic mutations of FOXA2:

 

Generating mutation plots.

 

Highly correlated genes for FOXA2:

 

Showing top 20/305 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FOXA2POU5F1B0.718376303
FOXA2NOS30.710886404
FOXA2KRTAP3-10.708281303
FOXA2C10orf910.6965303
FOXA2SHH0.693918505
FOXA2SLC22A120.690071303
FOXA2SLC25A180.685309303
FOXA2MAG0.68363404
FOXA2AVPR20.676595404
FOXA2C2CD4C0.669638303
FOXA2SLC12A30.66127403
FOXA2SLC8A30.657532404
FOXA2CHGB0.656321403
FOXA2MC1R0.650526504
FOXA2SPRED30.648712403
FOXA2AMBN0.645425404
FOXA2CDRT150.640346303
FOXA2PRSS530.639099504
FOXA2CYP17A10.635841503
FOXA2ANO70.633204403

For details and further investigation, click here