| Full name: cyclin dependent kinase like 3 | Alias Symbol: NKIAMRE | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 51265 | HGNC ID: HGNC:15483 | Ensembl Gene: ENSG00000006837 | OMIM ID: 608459 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CDKL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKL3 | 51265 | 219831_at | -0.0142 | 0.9799 | |
| GSE20347 | CDKL3 | 51265 | 219831_at | 0.0726 | 0.4942 | |
| GSE23400 | CDKL3 | 51265 | 219831_at | -0.0431 | 0.2438 | |
| GSE26886 | CDKL3 | 51265 | 236017_at | 0.3928 | 0.1357 | |
| GSE29001 | CDKL3 | 51265 | 219831_at | 0.2801 | 0.2966 | |
| GSE38129 | CDKL3 | 51265 | 219831_at | -0.0552 | 0.6677 | |
| GSE45670 | CDKL3 | 51265 | 219831_at | 0.0575 | 0.7604 | |
| GSE63941 | CDKL3 | 51265 | 219831_at | -1.2210 | 0.0065 | |
| GSE77861 | CDKL3 | 51265 | 236017_at | -0.0769 | 0.5811 | |
| GSE97050 | CDKL3 | 51265 | A_23_P110643 | -0.4001 | 0.1636 | |
| SRP064894 | CDKL3 | 51265 | RNAseq | 0.4432 | 0.0693 | |
| SRP133303 | CDKL3 | 51265 | RNAseq | 0.3382 | 0.2993 | |
| SRP159526 | CDKL3 | 51265 | RNAseq | 0.2127 | 0.5588 | |
| SRP219564 | CDKL3 | 51265 | RNAseq | -0.1411 | 0.7447 | |
| TCGA | CDKL3 | 51265 | RNAseq | -0.1932 | 0.1044 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CDKL3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CDKL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKL3 | 51265 | 2 | 11 | 17 | |
| GSE20123 | CDKL3 | 51265 | 3 | 11 | 16 | |
| GSE43470 | CDKL3 | 51265 | 2 | 8 | 33 | |
| GSE46452 | CDKL3 | 51265 | 0 | 27 | 32 | |
| GSE47630 | CDKL3 | 51265 | 0 | 21 | 19 | |
| GSE54993 | CDKL3 | 51265 | 9 | 1 | 60 | |
| GSE54994 | CDKL3 | 51265 | 2 | 14 | 37 | |
| GSE60625 | CDKL3 | 51265 | 0 | 0 | 11 | |
| GSE74703 | CDKL3 | 51265 | 2 | 5 | 29 | |
| GSE74704 | CDKL3 | 51265 | 2 | 5 | 13 | |
| TCGA | CDKL3 | 51265 | 3 | 36 | 57 |
Total number of gains: 25; Total number of losses: 139; Total Number of normals: 324.
Somatic mutations of CDKL3:
Generating mutation plots.
Highly correlated genes for CDKL3:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKL3 | HCFC1R1 | 0.795629 | 3 | 0 | 3 |
| CDKL3 | ZMYM4 | 0.769446 | 3 | 0 | 3 |
| CDKL3 | CBLL1 | 0.763922 | 3 | 0 | 3 |
| CDKL3 | BBS7 | 0.758979 | 3 | 0 | 3 |
| CDKL3 | CD99L2 | 0.750177 | 3 | 0 | 3 |
| CDKL3 | HSPA12A | 0.748857 | 3 | 0 | 3 |
| CDKL3 | PRICKLE2 | 0.748652 | 3 | 0 | 3 |
| CDKL3 | LSM11 | 0.747907 | 3 | 0 | 3 |
| CDKL3 | WFDC3 | 0.723603 | 3 | 0 | 3 |
| CDKL3 | KIAA1328 | 0.721992 | 4 | 0 | 3 |
| CDKL3 | PKD2 | 0.710769 | 4 | 0 | 4 |
| CDKL3 | PLEKHO1 | 0.710301 | 3 | 0 | 3 |
| CDKL3 | FAM13A | 0.710145 | 3 | 0 | 3 |
| CDKL3 | MRGPRF | 0.707641 | 3 | 0 | 3 |
| CDKL3 | ARMCX3 | 0.705896 | 3 | 0 | 3 |
| CDKL3 | ZNF12 | 0.702929 | 3 | 0 | 3 |
| CDKL3 | TTLL11 | 0.701358 | 3 | 0 | 3 |
| CDKL3 | FGGY | 0.699343 | 3 | 0 | 3 |
| CDKL3 | CDAN1 | 0.69924 | 4 | 0 | 4 |
| CDKL3 | PLEKHB1 | 0.698767 | 6 | 0 | 6 |
For details and further investigation, click here
