| Full name: pleckstrin homology domain containing B1 | Alias Symbol: PHR1|KPL1 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 58473 | HGNC ID: HGNC:19079 | Ensembl Gene: ENSG00000021300 | OMIM ID: 607651 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHB1 | 58473 | 209504_s_at | -0.6166 | 0.5845 | |
| GSE20347 | PLEKHB1 | 58473 | 209504_s_at | 0.1121 | 0.2151 | |
| GSE23400 | PLEKHB1 | 58473 | 209504_s_at | -0.2631 | 0.0004 | |
| GSE26886 | PLEKHB1 | 58473 | 229047_at | -0.0657 | 0.5445 | |
| GSE29001 | PLEKHB1 | 58473 | 209504_s_at | 0.0096 | 0.9550 | |
| GSE38129 | PLEKHB1 | 58473 | 209504_s_at | -0.6242 | 0.0918 | |
| GSE45670 | PLEKHB1 | 58473 | 229047_at | -0.0858 | 0.4837 | |
| GSE53622 | PLEKHB1 | 58473 | 17026 | -1.7829 | 0.0000 | |
| GSE53624 | PLEKHB1 | 58473 | 17026 | -1.5304 | 0.0000 | |
| GSE63941 | PLEKHB1 | 58473 | 209504_s_at | 1.0883 | 0.2085 | |
| GSE77861 | PLEKHB1 | 58473 | 229047_at | -0.0474 | 0.6531 | |
| GSE97050 | PLEKHB1 | 58473 | A_33_P3308332 | -0.8665 | 0.1453 | |
| SRP064894 | PLEKHB1 | 58473 | RNAseq | -1.2925 | 0.0137 | |
| SRP133303 | PLEKHB1 | 58473 | RNAseq | -1.8046 | 0.0005 | |
| SRP159526 | PLEKHB1 | 58473 | RNAseq | -0.5121 | 0.1498 | |
| TCGA | PLEKHB1 | 58473 | RNAseq | -1.3107 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PLEKHB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHB1 | 58473 | 5 | 9 | 16 | |
| GSE20123 | PLEKHB1 | 58473 | 5 | 8 | 17 | |
| GSE43470 | PLEKHB1 | 58473 | 8 | 2 | 33 | |
| GSE46452 | PLEKHB1 | 58473 | 9 | 20 | 30 | |
| GSE47630 | PLEKHB1 | 58473 | 7 | 13 | 20 | |
| GSE54993 | PLEKHB1 | 58473 | 8 | 2 | 60 | |
| GSE54994 | PLEKHB1 | 58473 | 8 | 15 | 30 | |
| GSE60625 | PLEKHB1 | 58473 | 0 | 7 | 4 | |
| GSE74703 | PLEKHB1 | 58473 | 6 | 2 | 28 | |
| GSE74704 | PLEKHB1 | 58473 | 3 | 4 | 13 | |
| TCGA | PLEKHB1 | 58473 | 28 | 27 | 41 |
Total number of gains: 87; Total number of losses: 109; Total Number of normals: 292.
Somatic mutations of PLEKHB1:
Generating mutation plots.
Highly correlated genes for PLEKHB1:
Showing top 20/675 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHB1 | TMOD1 | 0.822679 | 5 | 0 | 5 |
| PLEKHB1 | UBXN10 | 0.807772 | 3 | 0 | 3 |
| PLEKHB1 | RASD2 | 0.79964 | 3 | 0 | 3 |
| PLEKHB1 | AFF3 | 0.785959 | 3 | 0 | 3 |
| PLEKHB1 | IQUB | 0.785279 | 3 | 0 | 3 |
| PLEKHB1 | XKR4 | 0.78127 | 4 | 0 | 4 |
| PLEKHB1 | CLEC3B | 0.771206 | 3 | 0 | 3 |
| PLEKHB1 | PCMTD1 | 0.764852 | 3 | 0 | 3 |
| PLEKHB1 | HOXA4 | 0.762426 | 4 | 0 | 4 |
| PLEKHB1 | PNRC2 | 0.761654 | 3 | 0 | 3 |
| PLEKHB1 | EIF4E3 | 0.761442 | 4 | 0 | 4 |
| PLEKHB1 | CBX7 | 0.757328 | 7 | 0 | 7 |
| PLEKHB1 | RNASE4 | 0.756179 | 4 | 0 | 4 |
| PLEKHB1 | COMMD6 | 0.75099 | 3 | 0 | 3 |
| PLEKHB1 | PPP3CB | 0.749485 | 5 | 0 | 5 |
| PLEKHB1 | CFL2 | 0.740248 | 4 | 0 | 4 |
| PLEKHB1 | HINT2 | 0.739293 | 3 | 0 | 3 |
| PLEKHB1 | SH3BGR | 0.738636 | 7 | 0 | 7 |
| PLEKHB1 | RTN2 | 0.738185 | 3 | 0 | 3 |
| PLEKHB1 | MAMDC2 | 0.737171 | 4 | 0 | 4 |
For details and further investigation, click here
