| Full name: prickle planar cell polarity protein 2 | Alias Symbol: DKFZp686D143 | ||
| Type: protein-coding gene | Cytoband: 3p14.1 | ||
| Entrez ID: 166336 | HGNC ID: HGNC:20340 | Ensembl Gene: ENSG00000163637 | OMIM ID: 608501 |
| Drug and gene relationship at DGIdb | |||
PRICKLE2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of PRICKLE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRICKLE2 | 166336 | 225968_at | -0.8883 | 0.2257 | |
| GSE26886 | PRICKLE2 | 166336 | 225968_at | 0.2492 | 0.4300 | |
| GSE45670 | PRICKLE2 | 166336 | 225968_at | -1.2477 | 0.0000 | |
| GSE53622 | PRICKLE2 | 166336 | 18304 | -1.2593 | 0.0000 | |
| GSE53624 | PRICKLE2 | 166336 | 18304 | -1.0116 | 0.0000 | |
| GSE63941 | PRICKLE2 | 166336 | 225968_at | -4.8324 | 0.0000 | |
| GSE77861 | PRICKLE2 | 166336 | 225968_at | -0.3873 | 0.0306 | |
| GSE97050 | PRICKLE2 | 166336 | A_24_P152188 | -1.1456 | 0.1069 | |
| SRP007169 | PRICKLE2 | 166336 | RNAseq | 0.6706 | 0.0993 | |
| SRP008496 | PRICKLE2 | 166336 | RNAseq | 1.2501 | 0.0036 | |
| SRP064894 | PRICKLE2 | 166336 | RNAseq | -0.1983 | 0.5283 | |
| SRP133303 | PRICKLE2 | 166336 | RNAseq | -0.1284 | 0.6060 | |
| SRP159526 | PRICKLE2 | 166336 | RNAseq | -0.8051 | 0.0189 | |
| SRP193095 | PRICKLE2 | 166336 | RNAseq | -0.0604 | 0.7179 | |
| SRP219564 | PRICKLE2 | 166336 | RNAseq | -0.5531 | 0.4333 | |
| TCGA | PRICKLE2 | 166336 | RNAseq | -0.5912 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by PRICKLE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRICKLE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRICKLE2 | 166336 | 0 | 17 | 13 | |
| GSE20123 | PRICKLE2 | 166336 | 0 | 18 | 12 | |
| GSE43470 | PRICKLE2 | 166336 | 0 | 19 | 24 | |
| GSE46452 | PRICKLE2 | 166336 | 2 | 17 | 40 | |
| GSE47630 | PRICKLE2 | 166336 | 1 | 24 | 15 | |
| GSE54993 | PRICKLE2 | 166336 | 5 | 2 | 63 | |
| GSE54994 | PRICKLE2 | 166336 | 1 | 33 | 19 | |
| GSE60625 | PRICKLE2 | 166336 | 3 | 1 | 7 | |
| GSE74703 | PRICKLE2 | 166336 | 0 | 15 | 21 | |
| GSE74704 | PRICKLE2 | 166336 | 0 | 12 | 8 | |
| TCGA | PRICKLE2 | 166336 | 0 | 77 | 19 |
Total number of gains: 12; Total number of losses: 235; Total Number of normals: 241.
Somatic mutations of PRICKLE2:
Generating mutation plots.
Highly correlated genes for PRICKLE2:
Showing top 20/1144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRICKLE2 | SYNC | 0.869688 | 4 | 0 | 4 |
| PRICKLE2 | SACS | 0.836828 | 3 | 0 | 3 |
| PRICKLE2 | FOXN3 | 0.833079 | 3 | 0 | 3 |
| PRICKLE2 | HABP4 | 0.824298 | 4 | 0 | 4 |
| PRICKLE2 | TOB2 | 0.811926 | 3 | 0 | 3 |
| PRICKLE2 | FAM98B | 0.811825 | 3 | 0 | 3 |
| PRICKLE2 | AGTR1 | 0.806863 | 6 | 0 | 6 |
| PRICKLE2 | DIXDC1 | 0.806523 | 6 | 0 | 6 |
| PRICKLE2 | MAP4 | 0.801177 | 3 | 0 | 3 |
| PRICKLE2 | RAP1A | 0.793631 | 6 | 0 | 6 |
| PRICKLE2 | NFASC | 0.79308 | 4 | 0 | 4 |
| PRICKLE2 | FXYD1 | 0.786335 | 3 | 0 | 3 |
| PRICKLE2 | SLIT3 | 0.786078 | 4 | 0 | 4 |
| PRICKLE2 | DNALI1 | 0.783879 | 5 | 0 | 5 |
| PRICKLE2 | PARVA | 0.777114 | 6 | 0 | 6 |
| PRICKLE2 | RNASE4 | 0.774324 | 4 | 0 | 3 |
| PRICKLE2 | C1QTNF7 | 0.770108 | 5 | 0 | 5 |
| PRICKLE2 | PDE5A | 0.769925 | 7 | 0 | 7 |
| PRICKLE2 | NPTN | 0.763869 | 5 | 0 | 5 |
| PRICKLE2 | ARHGAP6 | 0.76098 | 6 | 0 | 6 |
For details and further investigation, click here
