PKD2

 

Full name: polycystin 2, transient receptor potential cation channel Alias Symbol: PKD4|PC2|Pc-2|TRPP2
Type: protein-coding gene Cytoband: 4q22.1
Entrez ID: 5311 HGNC ID: HGNC:9009 Ensembl Gene: ENSG00000118762 OMIM ID: 173910
Drug and gene relationship at DGIdb

 

Expression of PKD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PKD2 5311 203688_at -0.3153 0.6898
GSE20347 PKD2 5311 203688_at 0.3085 0.0632
GSE23400 PKD2 5311 203688_at 0.3040 0.0311
GSE26886 PKD2 5311 203688_at 1.1130 0.0004
GSE29001 PKD2 5311 203688_at 0.2223 0.4503
GSE38129 PKD2 5311 203688_at -0.0558 0.8453
GSE45670 PKD2 5311 203688_at -0.7169 0.0010
GSE53622 PKD2 5311 39994 0.2015 0.0676
GSE53624 PKD2 5311 39994 0.2176 0.0367
GSE63941 PKD2 5311 203688_at -2.5867 0.0001
GSE77861 PKD2 5311 203688_at 0.4891 0.1440
GSE97050 PKD2 5311 A_24_P106112 -0.5943 0.1581
SRP007169 PKD2 5311 RNAseq 1.4514 0.0000
SRP008496 PKD2 5311 RNAseq 1.5007 0.0000
SRP064894 PKD2 5311 RNAseq 0.3451 0.2502
SRP133303 PKD2 5311 RNAseq 0.3605 0.1064
SRP159526 PKD2 5311 RNAseq 0.4391 0.0873
SRP193095 PKD2 5311 RNAseq 0.5946 0.0000
SRP219564 PKD2 5311 RNAseq 0.0534 0.9175
TCGA PKD2 5311 RNAseq -0.1693 0.0180

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by PKD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PKD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PKD2 5311 3 12 15
GSE20123 PKD2 5311 3 12 15
GSE43470 PKD2 5311 0 13 30
GSE46452 PKD2 5311 1 36 22
GSE47630 PKD2 5311 0 20 20
GSE54993 PKD2 5311 8 0 62
GSE54994 PKD2 5311 1 10 42
GSE60625 PKD2 5311 0 0 11
GSE74703 PKD2 5311 0 11 25
GSE74704 PKD2 5311 2 7 11
TCGA PKD2 5311 12 36 48

Total number of gains: 30; Total number of losses: 157; Total Number of normals: 301.  

 

Somatic mutations of PKD2:

 

Generating mutation plots.

 

Highly correlated genes for PKD2:

 

Showing top 20/1351 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PKD2TMEM1810.805402303
PKD2FNIP20.785263404
PKD2SGCD0.764129808
PKD2SPATA90.758364303
PKD2RASSF80.75488707
PKD2SYNC0.747821606
PKD2ZEB10.746854303
PKD2TBX5-AS10.731984505
PKD2CDH60.727621404
PKD2ZBTB260.722019504
PKD2TMEM178A0.721548303
PKD2LAMC10.72131113013
PKD2ANGPTL10.717358404
PKD2TMEM1300.716883303
PKD2ROCK20.71447707
PKD2GALNT150.713865404
PKD2STARD90.711536504
PKD2CDKL30.710769404
PKD2FAM118B0.710647404
PKD2EFEMP20.70926610010

For details and further investigation, click here