| Full name: cyclin dependent kinase like 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p22.1 | ||
| Entrez ID: 344387 | HGNC ID: HGNC:19287 | Ensembl Gene: ENSG00000205111 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CDKL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CDKL4 | 344387 | 74333 | 0.4043 | 0.0000 | |
| GSE53624 | CDKL4 | 344387 | 74333 | 0.3218 | 0.0023 | |
| GSE97050 | CDKL4 | 344387 | A_33_P3357490 | -0.1220 | 0.5756 | |
| SRP133303 | CDKL4 | 344387 | RNAseq | 0.4039 | 0.0751 | |
| TCGA | CDKL4 | 344387 | RNAseq | 1.6054 | 0.2247 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDKL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKL4 | 344387 | 11 | 1 | 18 | |
| GSE20123 | CDKL4 | 344387 | 9 | 1 | 20 | |
| GSE43470 | CDKL4 | 344387 | 3 | 0 | 40 | |
| GSE46452 | CDKL4 | 344387 | 1 | 4 | 54 | |
| GSE47630 | CDKL4 | 344387 | 7 | 0 | 33 | |
| GSE54993 | CDKL4 | 344387 | 0 | 5 | 65 | |
| GSE54994 | CDKL4 | 344387 | 10 | 0 | 43 | |
| GSE60625 | CDKL4 | 344387 | 0 | 3 | 8 | |
| GSE74703 | CDKL4 | 344387 | 3 | 0 | 33 | |
| GSE74704 | CDKL4 | 344387 | 9 | 1 | 10 | |
| TCGA | CDKL4 | 344387 | 35 | 2 | 59 |
Total number of gains: 88; Total number of losses: 17; Total Number of normals: 383.
Somatic mutations of CDKL4:
Generating mutation plots.
Highly correlated genes for CDKL4:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKL4 | TRIM46 | 0.791272 | 3 | 0 | 3 |
| CDKL4 | WDR87 | 0.767387 | 3 | 0 | 3 |
| CDKL4 | TTLL9 | 0.76444 | 3 | 0 | 3 |
| CDKL4 | ZNF527 | 0.75557 | 3 | 0 | 3 |
| CDKL4 | KCNH3 | 0.751138 | 3 | 0 | 3 |
| CDKL4 | TRIM10 | 0.750791 | 3 | 0 | 3 |
| CDKL4 | OR1J4 | 0.746282 | 3 | 0 | 3 |
| CDKL4 | FAM71F1 | 0.743067 | 3 | 0 | 3 |
| CDKL4 | DEFB121 | 0.743008 | 3 | 0 | 3 |
| CDKL4 | SLC26A1 | 0.741576 | 3 | 0 | 3 |
| CDKL4 | SERPINA10 | 0.74125 | 3 | 0 | 3 |
| CDKL4 | TNFAIP8L1 | 0.740722 | 3 | 0 | 3 |
| CDKL4 | PROCA1 | 0.740276 | 3 | 0 | 3 |
| CDKL4 | FAM181A | 0.73761 | 3 | 0 | 3 |
| CDKL4 | PAX6 | 0.736775 | 3 | 0 | 3 |
| CDKL4 | NPPB | 0.735632 | 3 | 0 | 3 |
| CDKL4 | SLC22A11 | 0.735164 | 3 | 0 | 3 |
| CDKL4 | TMEM235 | 0.735131 | 3 | 0 | 3 |
| CDKL4 | GJD4 | 0.733815 | 3 | 0 | 3 |
| CDKL4 | SLC6A3 | 0.732744 | 3 | 0 | 3 |
For details and further investigation, click here
