| Full name: natriuretic peptide B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 4879 | HGNC ID: HGNC:7940 | Ensembl Gene: ENSG00000120937 | OMIM ID: 600295 |
| Drug and gene relationship at DGIdb | |||
NPPB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of NPPB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPPB | 4879 | 206801_at | 0.0681 | 0.8338 | |
| GSE20347 | NPPB | 4879 | 206801_at | 0.0786 | 0.4577 | |
| GSE23400 | NPPB | 4879 | 206801_at | -0.0719 | 0.0217 | |
| GSE26886 | NPPB | 4879 | 206801_at | 0.1883 | 0.0861 | |
| GSE29001 | NPPB | 4879 | 206801_at | -0.0378 | 0.7503 | |
| GSE38129 | NPPB | 4879 | 206801_at | -0.0502 | 0.5884 | |
| GSE45670 | NPPB | 4879 | 206801_at | 0.0616 | 0.5753 | |
| GSE53622 | NPPB | 4879 | 67249 | 0.2171 | 0.0013 | |
| GSE53624 | NPPB | 4879 | 67249 | 0.4457 | 0.0000 | |
| GSE63941 | NPPB | 4879 | 206801_at | 0.1539 | 0.3266 | |
| GSE77861 | NPPB | 4879 | 206801_at | -0.0961 | 0.4204 | |
| GSE97050 | NPPB | 4879 | A_33_P3362008 | 0.0464 | 0.8432 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NPPB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPPB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPPB | 4879 | 0 | 5 | 25 | |
| GSE20123 | NPPB | 4879 | 0 | 4 | 26 | |
| GSE43470 | NPPB | 4879 | 4 | 6 | 33 | |
| GSE46452 | NPPB | 4879 | 7 | 1 | 51 | |
| GSE47630 | NPPB | 4879 | 8 | 4 | 28 | |
| GSE54993 | NPPB | 4879 | 3 | 1 | 66 | |
| GSE54994 | NPPB | 4879 | 11 | 4 | 38 | |
| GSE60625 | NPPB | 4879 | 0 | 0 | 11 | |
| GSE74703 | NPPB | 4879 | 3 | 4 | 29 | |
| GSE74704 | NPPB | 4879 | 0 | 0 | 20 | |
| TCGA | NPPB | 4879 | 10 | 22 | 64 |
Total number of gains: 46; Total number of losses: 51; Total Number of normals: 391.
Somatic mutations of NPPB:
Generating mutation plots.
Highly correlated genes for NPPB:
Showing top 20/1067 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPPB | STRC | 0.863483 | 3 | 0 | 3 |
| NPPB | C9orf153 | 0.852749 | 3 | 0 | 3 |
| NPPB | MRGPRG | 0.825431 | 3 | 0 | 3 |
| NPPB | C19orf71 | 0.816792 | 3 | 0 | 3 |
| NPPB | C2CD4D | 0.811 | 3 | 0 | 3 |
| NPPB | FAM131A | 0.802219 | 3 | 0 | 3 |
| NPPB | C1QL2 | 0.800554 | 3 | 0 | 3 |
| NPPB | PLA2G2C | 0.799265 | 3 | 0 | 3 |
| NPPB | KLRG2 | 0.791884 | 3 | 0 | 3 |
| NPPB | LHB | 0.790284 | 3 | 0 | 3 |
| NPPB | DCDC1 | 0.780707 | 3 | 0 | 3 |
| NPPB | MS4A18 | 0.776766 | 3 | 0 | 3 |
| NPPB | CD72 | 0.771936 | 3 | 0 | 3 |
| NPPB | YY2 | 0.771243 | 3 | 0 | 3 |
| NPPB | DEFB128 | 0.768511 | 3 | 0 | 3 |
| NPPB | ANKRD33B | 0.758919 | 3 | 0 | 3 |
| NPPB | TTC12 | 0.756745 | 3 | 0 | 3 |
| NPPB | OR2T27 | 0.756573 | 3 | 0 | 3 |
| NPPB | QRFP | 0.756333 | 3 | 0 | 3 |
| NPPB | OR2A5 | 0.75061 | 3 | 0 | 3 |
For details and further investigation, click here
