| Full name: defensin beta 121 | Alias Symbol: DEFB-21 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 245934 | HGNC ID: HGNC:18101 | Ensembl Gene: ENSG00000204548 | OMIM ID: 616075 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFB121:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB121 | 245934 | 234007_at | -0.0916 | 0.7075 | |
| GSE26886 | DEFB121 | 245934 | 234007_at | -0.1366 | 0.1888 | |
| GSE45670 | DEFB121 | 245934 | 234007_at | 0.0409 | 0.5994 | |
| GSE53622 | DEFB121 | 245934 | 134391 | 0.3359 | 0.0003 | |
| GSE53624 | DEFB121 | 245934 | 134391 | 0.3772 | 0.0002 | |
| GSE63941 | DEFB121 | 245934 | 234007_at | 0.1109 | 0.3007 | |
| GSE77861 | DEFB121 | 245934 | 234007_at | -0.0719 | 0.3941 | |
| GSE97050 | DEFB121 | 245934 | A_33_P3408269 | 0.2817 | 0.2368 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB121 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFB121:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB121 | 245934 | 14 | 0 | 16 | |
| GSE20123 | DEFB121 | 245934 | 14 | 0 | 16 | |
| GSE43470 | DEFB121 | 245934 | 11 | 0 | 32 | |
| GSE46452 | DEFB121 | 245934 | 29 | 0 | 30 | |
| GSE47630 | DEFB121 | 245934 | 24 | 0 | 16 | |
| GSE54993 | DEFB121 | 245934 | 0 | 17 | 53 | |
| GSE54994 | DEFB121 | 245934 | 27 | 1 | 25 | |
| GSE60625 | DEFB121 | 245934 | 0 | 0 | 11 | |
| GSE74703 | DEFB121 | 245934 | 10 | 0 | 26 | |
| GSE74704 | DEFB121 | 245934 | 9 | 0 | 11 | |
| TCGA | DEFB121 | 245934 | 49 | 1 | 46 |
Total number of gains: 187; Total number of losses: 19; Total Number of normals: 282.
Somatic mutations of DEFB121:
Generating mutation plots.
Highly correlated genes for DEFB121:
Showing top 20/446 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB121 | DCDC1 | 0.894457 | 3 | 0 | 3 |
| DEFB121 | OR2A5 | 0.869307 | 3 | 0 | 3 |
| DEFB121 | PLA2G2D | 0.86731 | 3 | 0 | 3 |
| DEFB121 | ZNF763 | 0.866122 | 3 | 0 | 3 |
| DEFB121 | STRC | 0.860965 | 3 | 0 | 3 |
| DEFB121 | OR2T27 | 0.857084 | 3 | 0 | 3 |
| DEFB121 | RASL10B | 0.856045 | 3 | 0 | 3 |
| DEFB121 | OR2T1 | 0.849932 | 3 | 0 | 3 |
| DEFB121 | KCNH3 | 0.83208 | 4 | 0 | 4 |
| DEFB121 | PLA2G2C | 0.831257 | 3 | 0 | 3 |
| DEFB121 | YY2 | 0.830398 | 3 | 0 | 3 |
| DEFB121 | SLC18A3 | 0.830302 | 3 | 0 | 3 |
| DEFB121 | ZNF527 | 0.828642 | 3 | 0 | 3 |
| DEFB121 | FFAR1 | 0.826937 | 4 | 0 | 4 |
| DEFB121 | DEFB128 | 0.826932 | 3 | 0 | 3 |
| DEFB121 | PAX6 | 0.822894 | 3 | 0 | 3 |
| DEFB121 | KRTAP10-12 | 0.818458 | 3 | 0 | 3 |
| DEFB121 | RBM43 | 0.816508 | 3 | 0 | 3 |
| DEFB121 | PTAFR | 0.815398 | 3 | 0 | 3 |
| DEFB121 | DEFB108B | 0.814989 | 3 | 0 | 3 |
For details and further investigation, click here
