| Full name: CCAAT enhancer binding protein alpha | Alias Symbol: C/EBP-alpha | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 1050 | HGNC ID: HGNC:1833 | Ensembl Gene: ENSG00000245848 | OMIM ID: 116897 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CEBPA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | |
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of CEBPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CEBPA | 1050 | 204039_at | 0.8282 | 0.1858 | |
| GSE20347 | CEBPA | 1050 | 204039_at | 0.1576 | 0.4350 | |
| GSE23400 | CEBPA | 1050 | 204039_at | 0.2692 | 0.0143 | |
| GSE26886 | CEBPA | 1050 | 204039_at | -0.4291 | 0.0450 | |
| GSE29001 | CEBPA | 1050 | 204039_at | 0.2915 | 0.3828 | |
| GSE38129 | CEBPA | 1050 | 204039_at | 0.2544 | 0.2774 | |
| GSE45670 | CEBPA | 1050 | 204039_at | 0.5588 | 0.0244 | |
| GSE53622 | CEBPA | 1050 | 233 | 0.1079 | 0.2600 | |
| GSE53624 | CEBPA | 1050 | 233 | 0.3286 | 0.0001 | |
| GSE63941 | CEBPA | 1050 | 204039_at | 1.8809 | 0.0089 | |
| GSE77861 | CEBPA | 1050 | 204039_at | 0.2713 | 0.4851 | |
| GSE97050 | CEBPA | 1050 | A_24_P224727 | 0.7437 | 0.3284 | |
| SRP007169 | CEBPA | 1050 | RNAseq | -0.4738 | 0.2361 | |
| SRP008496 | CEBPA | 1050 | RNAseq | -0.4297 | 0.2226 | |
| SRP064894 | CEBPA | 1050 | RNAseq | 0.1712 | 0.6020 | |
| SRP133303 | CEBPA | 1050 | RNAseq | 0.1076 | 0.7687 | |
| SRP159526 | CEBPA | 1050 | RNAseq | 0.8487 | 0.0077 | |
| SRP193095 | CEBPA | 1050 | RNAseq | -0.2225 | 0.3089 | |
| SRP219564 | CEBPA | 1050 | RNAseq | -0.5156 | 0.3347 | |
| TCGA | CEBPA | 1050 | RNAseq | 0.2269 | 0.0413 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CEBPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CEBPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CEBPA | 1050 | 7 | 6 | 17 | |
| GSE20123 | CEBPA | 1050 | 7 | 5 | 18 | |
| GSE43470 | CEBPA | 1050 | 4 | 6 | 33 | |
| GSE46452 | CEBPA | 1050 | 47 | 1 | 11 | |
| GSE47630 | CEBPA | 1050 | 8 | 6 | 26 | |
| GSE54993 | CEBPA | 1050 | 17 | 3 | 50 | |
| GSE54994 | CEBPA | 1050 | 7 | 9 | 37 | |
| GSE60625 | CEBPA | 1050 | 9 | 0 | 2 | |
| GSE74703 | CEBPA | 1050 | 4 | 4 | 28 | |
| GSE74704 | CEBPA | 1050 | 6 | 3 | 11 | |
| TCGA | CEBPA | 1050 | 18 | 12 | 66 |
Total number of gains: 134; Total number of losses: 55; Total Number of normals: 299.
Somatic mutations of CEBPA:
Generating mutation plots.
Highly correlated genes for CEBPA:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CEBPA | CCDC137 | 0.731785 | 3 | 0 | 3 |
| CEBPA | GEN1 | 0.705588 | 3 | 0 | 3 |
| CEBPA | LINC01234 | 0.70168 | 3 | 0 | 3 |
| CEBPA | PIK3R3 | 0.698783 | 3 | 0 | 3 |
| CEBPA | RAB3IP | 0.694897 | 4 | 0 | 3 |
| CEBPA | MAGED1 | 0.69332 | 3 | 0 | 3 |
| CEBPA | LOR | 0.689572 | 3 | 0 | 3 |
| CEBPA | ANKRD16 | 0.689312 | 3 | 0 | 3 |
| CEBPA | NCAPD2 | 0.682514 | 3 | 0 | 3 |
| CEBPA | CSTF2T | 0.682296 | 3 | 0 | 3 |
| CEBPA | DHRS13 | 0.679229 | 4 | 0 | 4 |
| CEBPA | ZNF786 | 0.678536 | 4 | 0 | 4 |
| CEBPA | UHRF1BP1 | 0.677648 | 3 | 0 | 3 |
| CEBPA | FBXO5 | 0.677513 | 3 | 0 | 3 |
| CEBPA | DNAJC11 | 0.674769 | 4 | 0 | 4 |
| CEBPA | EHMT2 | 0.674531 | 3 | 0 | 3 |
| CEBPA | ZNF606 | 0.673014 | 3 | 0 | 3 |
| CEBPA | ABCF1 | 0.67005 | 4 | 0 | 3 |
| CEBPA | SLC39A11 | 0.66389 | 3 | 0 | 3 |
| CEBPA | ELAC2 | 0.661034 | 3 | 0 | 3 |
For details and further investigation, click here
