| Full name: GEN1 Holliday junction 5' flap endonuclease | Alias Symbol: FLJ40869|Gen | ||
| Type: protein-coding gene | Cytoband: 2p24.2 | ||
| Entrez ID: 348654 | HGNC ID: HGNC:26881 | Ensembl Gene: ENSG00000178295 | OMIM ID: 612449 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GEN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GEN1 | 348654 | 228286_at | 1.0003 | 0.1523 | |
| GSE26886 | GEN1 | 348654 | 228286_at | 0.0780 | 0.7845 | |
| GSE45670 | GEN1 | 348654 | 228286_at | 0.9328 | 0.0000 | |
| GSE53622 | GEN1 | 348654 | 32308 | 1.2174 | 0.0000 | |
| GSE53624 | GEN1 | 348654 | 32308 | 0.9324 | 0.0000 | |
| GSE63941 | GEN1 | 348654 | 228286_at | 0.2553 | 0.6461 | |
| GSE77861 | GEN1 | 348654 | 228286_at | 0.2120 | 0.4815 | |
| GSE97050 | GEN1 | 348654 | A_24_P177585 | 0.6630 | 0.2092 | |
| SRP007169 | GEN1 | 348654 | RNAseq | 1.1567 | 0.0159 | |
| SRP008496 | GEN1 | 348654 | RNAseq | 1.0331 | 0.0038 | |
| SRP064894 | GEN1 | 348654 | RNAseq | 0.5324 | 0.0470 | |
| SRP133303 | GEN1 | 348654 | RNAseq | 0.8443 | 0.0001 | |
| SRP159526 | GEN1 | 348654 | RNAseq | 0.4905 | 0.2411 | |
| SRP193095 | GEN1 | 348654 | RNAseq | 0.6162 | 0.0000 | |
| SRP219564 | GEN1 | 348654 | RNAseq | 0.3847 | 0.5202 | |
| TCGA | GEN1 | 348654 | RNAseq | 0.4366 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GEN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GEN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GEN1 | 348654 | 10 | 2 | 18 | |
| GSE20123 | GEN1 | 348654 | 10 | 2 | 18 | |
| GSE43470 | GEN1 | 348654 | 2 | 0 | 41 | |
| GSE46452 | GEN1 | 348654 | 3 | 4 | 52 | |
| GSE47630 | GEN1 | 348654 | 7 | 0 | 33 | |
| GSE54993 | GEN1 | 348654 | 0 | 7 | 63 | |
| GSE54994 | GEN1 | 348654 | 10 | 0 | 43 | |
| GSE60625 | GEN1 | 348654 | 0 | 3 | 8 | |
| GSE74703 | GEN1 | 348654 | 2 | 0 | 34 | |
| GSE74704 | GEN1 | 348654 | 9 | 2 | 9 | |
| TCGA | GEN1 | 348654 | 36 | 3 | 57 |
Total number of gains: 89; Total number of losses: 23; Total Number of normals: 376.
Somatic mutations of GEN1:
Generating mutation plots.
Highly correlated genes for GEN1:
Showing top 20/1191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GEN1 | FOXRED2 | 0.798649 | 3 | 0 | 3 |
| GEN1 | SLC1A5 | 0.793647 | 3 | 0 | 3 |
| GEN1 | RAD54L | 0.78986 | 3 | 0 | 3 |
| GEN1 | DSCC1 | 0.768116 | 4 | 0 | 4 |
| GEN1 | PPP2R1B | 0.763955 | 3 | 0 | 3 |
| GEN1 | ARHGEF19 | 0.762499 | 4 | 0 | 4 |
| GEN1 | NEK2 | 0.760099 | 6 | 0 | 6 |
| GEN1 | MGAT2 | 0.75936 | 3 | 0 | 3 |
| GEN1 | MAP3K11 | 0.758072 | 4 | 0 | 3 |
| GEN1 | FAM86C1 | 0.756726 | 3 | 0 | 3 |
| GEN1 | LMNB2 | 0.752291 | 5 | 0 | 4 |
| GEN1 | PRDM15 | 0.752044 | 3 | 0 | 3 |
| GEN1 | UMPS | 0.751819 | 5 | 0 | 5 |
| GEN1 | MYBL2 | 0.750186 | 5 | 0 | 5 |
| GEN1 | MMS22L | 0.7478 | 3 | 0 | 3 |
| GEN1 | CENPO | 0.745784 | 4 | 0 | 4 |
| GEN1 | SPATA2 | 0.744736 | 3 | 0 | 3 |
| GEN1 | DPP3 | 0.743767 | 4 | 0 | 4 |
| GEN1 | HDGF | 0.73713 | 5 | 0 | 5 |
| GEN1 | UBE2C | 0.736843 | 6 | 0 | 6 |
For details and further investigation, click here
